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Table 1 Comparison of two models in terms of characteristics and parameters used

From: Comparison of LiSTmeasles mortality model and WHO/IVB measles model

  WHO/IVB LiST
Model Natural history model Cohort model
Population 6month to 59 months, UN Population Division projection, revision 2008 6month to 59 months, UN Population Division projection, revision 2008
Coverage of measles vaccination MCV1, MCV2 and SIAs [WHO/UNICEF vaccine coverage estimates] MCV1, MCV2 and SIAs [WHO/UNICEF vaccine coverage estimates]
Protective effect of SIAs Account for SIAs in the target and the past 4 years Weighting factor: 100%, 90%, 80%, 50%, and 25% Account for SIAs in the target and the past 4 years Weighting factor: 100%, 88%, 64.7%, 41.2%, and 17.6%
Assumption of independence on vaccine receipt Assume children receive all three doses independently Assume children receive the second routine dose on top of receiving the first one. Assume receiving routine doses is independent from receiving SIAs
Coverage being able to distinguish for different age group Model could be modified to account for that if country-specific information is available Yes, if country-specific information is available
U5MR Not applicable LiST model uses it for computing number of death [UN estimates]
Vaccine Effectiveness 85% for dose 1, 95% for dose 2 and SIAs 85% for receiving MCV1 only, 94.2% for receiving SIA only and 98% for receiving more than 1 doses
Herd effect Not applicable Herd effect (HE) kicked in when proportion of population protected by MCV reached 90%. Twenty percent HE was added with 1% increment of protection proportion over 90%. HE reached 100% at 95% of the population directly protected by the vaccine, and all children who do not receive MCV would be protected.
Considering other cause of death Not applicable Yes Country-specific cause-of-death profile
Considering other intervention associated with measles infection or mortality Not applicable Yes Stunting, wasting, and vitamin A supplement
Country-specific CFRs / CFRs multiplication factor Yes Age-specific CFR, but the value could not adjust the value with availability of treatments or other intervention Not applicable
Age-specific case distribution Yes Different age distribution of cases owing to measles coverage higher or lower than 80% Not applicable