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Table 1 Quality assessment of trials of iron and/or folate on the incidence of anemia during pregnancy

From: Effect of routine iron supplementation with or without folic acid on anemia during pregnancy

  Quality Assessment Summary of Findings
No of studies (ref) Design Limitations Consistency Directness No of events  
     Generalizability to population of interest Generalizability to intervention of interest Intervention Control Relative Risk (95% CI)
Daily iron versus no intervention/placebo Anemia at term: Moderate outcome specific quality
14 RCT/quasi RCT Studies with unclear or inadequate sequence generation and high loss to follow-up All studies show direction of benefit, but high heterogeneity Only two studies in developing countries, rest in developed nations Yes 114 313 RR (random) = 0.27 [ 0.17, 0.42 ]
Daily iron versus no intervention/placebo : Iron deficiency anemia at term: Moderate outcome specific quality
6 RCT/quasi RCT Studies with unclear or inadequate sequence generation and high loss to follow-up All studies show direction of benefit, with borderline heterogeneity Only one study in developing country, rest in developed Yes 25 68 RR (random) = 0.33 [ 0.16, 0.69 ]
Daily iron and folic acid versus no intervention/placebo : Anemia at term: Moderate outcome specific quality
3 RCT/quasi-RCTs High loss to follow-up and unclear sequence generation Two studies show direction of benefit; while the third study had zero events Only one study in developing country, rest in developed Yes 17 49 RR (random) = 0.27 [ 0.12, 0.56 ]
Daily iron and folic acid versus no intervention/placebo: Iron deficiency anemia at term: Low outcome specific quality
1 RCT Allocation concealment unclear and blinding inadequate One study only In a developed country Yes 12 5 RR (random) = 0.43 [0.17, 1.09]