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Table 1 Quality grading of outcomes according to the CHERG approach using adapted GRADE criteria

From: Effect of screening and management of diabetes during pregnancy on stillbirths

No of studies (ref)

Design

Limitations

Consistency

Generalizability to population of interest

Generalizability to intervention of interest

Intervention

Control

Relative Risk (95% CI)

Intensified versus conventional management (Stillbirths): MODERATE outcome specific quality

4

3 RCTs,1 quasi RCT

Small study size in 1 study, 1 study not strictly randomized and 80% of the subjects were Hispanic so may not be generalizable.

2/4 studies showing direction of benefit, while the remaining two had zero total events

All in developed countries

Cannot separate diet controlled from diet and insulin controlled diabetes during pregnancy

1

8

RR (fixed) = 0.20 (0.03-1.10)