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Table 1 Results of pooled analysis and qualitative grading according to GRADE criteria for outcomes of interest for inclusion in the LiST:

From: Effect of balanced protein energy supplementation during pregnancy on birth outcomes

Quality Assessment Summary of Findings
     Directness No of patients Effect
No of studies Design Limitations Consistency Generalizability to Population of Interest Generalizability to Intervention of interest Intervention Control Relative Risk (95% CI)
Impact of balance protein energy supplementation on small for gestational age: Quality of evidence - Moderate
6[28, 3032, 35, 37] RCTs / Cluster RCT/ Quasi RCTs Two studies were quasi experimental trial. Sequence generation and allocation concealment was not adequate in some of the included studies. No heterogeneity in the pooled data (I2 =0%). p= 0.65 Studies conducted in both developed and developing countries. Protein content of Supplement for intervention group ranged from 30 g to 44 g per day. The protein content provided < 25 % of total energy content. 142 193 0.69 (0.56-0.85)
Impact of balance protein energy supplementation on neonatal mortality: Quality of evidence - Low
3[30, 37, 41] RCTs/ Cluster RCT/ Quasi RCTs One quasi-experimental design. Allocation concealment was not adequate for one of the included cluster randomized controlled trial. Large loss to follow up in included studies. No heterogeneity. (I2 =0) p=0.81 One study from developed country and two from developing countries Protein content of Supplement for intervention group ranged from 30 g to 44 g per day. The protein content provided < 25 % of total energy content. 23 33 0.63 (0.37-1.06)