CFR range among children not receiving effective treatment

Estimated CFR range among children receiving intravenous quinine

PE range using CFR of 3.4% for treated and 1321% for untreated

Midpoint PE of column 3

Lower bound

Upper bound


13.1%21.1%

3.4% (95% CI 1.65.2)

7687%

82%

63%

94%

 CFR: case fatality ratio
 Protective efficacy = (1Relative risk) * 100, where Relative risk = CFR receiving intravenous quinine / CFR not receiving effective antimalarial
 Lower bound based on sensitivity analysis where CFR among treated children is the upper bound for 95% confidence interval and CFR among untreated children is the lower of the two values for untreated children.
 Upper bound based on sensitivity analysis where CFR among treated children is the lower bound for 95% confidence interval and CFR among untreated children is the higher of the two values for untreated children.