Child age

CFR among children receiving no treatment (per 10,000)[14]

Estimated CFR among children receiving prompt ACT treatment (per 10,000)

Protective efficacy

Lower bound

Upper bound


<2 years

500

6.8

98.6%

94.4%

99.7%

25 years

200

6.8

96.6%

86.0%

99.3%

 CFR: case fatality ratio
 Protective efficacy = (1Relative risk) * 100, where Relative risk = CFR receiving ACT / CFR no treatment
 Lower bound based on sensitivity analysis where CFR among treated children assumed double (14 per 10,000) and CFR among untreated children assumed to be half (250 and 100 per 10,000 for children <2 and 25 years old, respectively).
 Upper bound based on sensitivity analysis where CFR among treated children assumed to be half (3 per 10,000) and CFR among untreated children assumed to be double (1,000 and 400 per 10,000 for children <2 and 25 years old, respectively).