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Table 7 Effect of case management on neonatal sepsis and pneumonia cause specific mortality, and GRADE of the estimate

From: Effect of case management on neonatal mortality due to sepsis and pneumonia

Effect on neonatal deaths due to pneumonia
Cause specific effect and 95% CI/ interquartile range:
Oral therapy 42% (18-59%,95% CI)
Injection therapy 75% (70-81% interquartile range on Delphi)
Hospital-based case management 90% (89-95% interquartile range on Delphi)
Quality of input evidence:
For oral therapy, moderate (3 low quality non-randomized concurrent control studies)
For the effects of injection therapy and full case management, the level of evidence is very low (based on Delphi).
Proximity of the data to cause specific mortality effect:
Moderate for oral therapy as several low quality but consistent studies; however, lack of consistency in cause-of-death definitions
Very low quality for injection therapy and full case management as these results are based on Delphi
Limitations of the evidence:
Interpretation of the data is limited by concurrent interventions particularly for studies with injection case management
Possible adverse effects:
Data not reviewed
Effect on neonatal deaths due to sepsis and meningitis
Cause specific effect and interquartile range:
Oral therapy 28% (20-36.25% interquartile range on Delphi)
Injection therapy 65% (50-70% interquartile range on Delphi)
Hospital-based management 80% (75-85% interquartile range on Delphi)
Quality of input evidence:
Very low (based on Delphi)
Proximity of the data to cause specific mortality effect:
Direct effect estimated by Delphi
Limitations of the evidence:
Lack of direct evidence on sepsis-specific mortality. Studies have evaluated injectable antibiotics as part of multiple co-intervention peri-natal care packages.
Possible adverse effects:
Data not reviewed