Table 3 GRADE assessment of studies of effect of case management on cause specific neonatal mortality due to pneumonia
From: Effect of case management on neonatal mortality due to sepsis and pneumonia
Quality Assessment | Summary of Findings | |||||||
|---|---|---|---|---|---|---|---|---|
No. of Events | Effect | |||||||
No. of studies | Design | Limitations | Consistency | Generalizability to Population of Interest: means to the “population” | Generalizability of the Intervention of interest | Intervention | Control | Relative Risk (95% CI) |
Mortality Pneumonia – community based oral antibiotic studies | ||||||||
4 | 1 randomized 3 Non randomized - concurrent control | Studies are not randomized, coverage of intervention are estimates, exact data not available, intensity of co-interventions varies between studies | Findings from the 4 studies all show direct mortality reduction benefit, although in 3 of the 4 studies included in the meta analysis, the effect reduction is not significant. | Yes, studies were all done in high neonatal mortality regions. | 3 of the 4 studies show direct effect on pneumonia specific mortality. 1 shows effect on overall neonatal mortality | 248/ 6542 | 63/ 4538 | *All-cause mortality 0.75 (0.64- 0.89) **Pneumonia Specific 0.58 (0.41- 0.82) |
Mortality Pneumonia - community based injectable antibiotic studies | ||||||||
No studies identified | ||||||||
Mortality Pneumonia - hospital-based case management | ||||||||
2 | Both observational study design | Not trials | CFR: 14.4% (28/195) and 30.8% (8/26) | Both studies from low income South Asian countries. | The study reporting higher CFR had high proportion (60%) of LBW babies. | N/A | N/A | N/A |