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Table 1 Definitions of interventions reviewed

From: Effect of case management on neonatal mortality due to sepsis and pneumonia

Oral antibiotic therapy alone

• Administration of oral antibiotics in the community for neonatal sepsis, meningitis, or pneumonia

Injection therapy alone

• Administration of intramuscular antibiotics, at home or in first-level facilities, for neonatal sepsis, meningitis, or pneumonia

Hospital-based management as an inpatient with supportive care

• Administration of intravenous antibiotics

â—‹ Wider choice of antibiotics including broad spectrum antibiotics

â—‹ Option of using frequent/higher dosage if needed to maintain high blood antibiotic levels or coverage for meningitis,

â—‹ Access to second-line antibiotic therapy for neonates with treatment failure on first line antibiotics

• Intravenous access and administration of intravenous fluids if needed

• Oxygen supplementation if required

• Access to appropriate diagnostic procedures, such as monitoring of pulse, blood pressure, and oximetry reading, as well as monitoring/correction of hypoglycemia if required