Author | Setting/Country | Study Design | Intervention definition | Outcomes: definition | Distinguish Preterm from Intrapartum Deaths | N (Births) A = Baseline B = Endline | Effect Size RR/OR (95%CI) |
---|---|---|---|---|---|---|---|
Zhu XY et al 1997[3] | Urban Hospital China | Before-and-after study | AAP NRP training at of all delivery room staff at hospital | 1) Early Neonatal Mortality (first 7 days): ALL cause | Not stated | A) 1,722; B) 4,751 | 1) RR 0.34 (0.17-0.67) |
Deorari AK et al 2001[2] | 14 University Hospitals, India | Before-and-after study | AAP NRP training of 2 faculty/hospital, subsequent training of DR room nurses and doctors; competency based certification | 1) Asphyxia neonatal mortality [Features of fetal hypoxia and 5 min Apgar <6 following complications of pregnancy or delivery]; 2) Hypoxic Ischemic Encephalopathy; 3) Preterm mortality [BW < 1000 g with HMD, IVH or AOP] | Excluded BW < 1000 g, death from HMD/IVH or AOP | A) 7,070; B)25,713 | 1) RR 0.70 (0.56-0.87) 2) RR 1.68 (1.06-2.67) 3) RR 0.95 (0.74-1.24) |
Vakrilova L et al 2005[44] | All hospitals with delivery rooms in Bulgaria | Before-and-after study | French-Bulgarian Program on Newborn Resuscitation, training in all obstetric wards in country | 1) Asphyxia Neonatal Mortality [ICD 9 'perinatal and intrapartum asphyxia'], 2) Early neonatal mortality (first 7 days) 3) Preterm complication [ICD-9 'immaturity related' and 'respiratory distress syndrome'] | Excluded death due to preterm complications by ICD-9 | A) 67,948; B) 67,647 | 1) RR 0.83 (0.54-1.27) 2) RR 0.86 (0.74-1.01) 3) RR 1.33 (1.03-1.73) |
18 Urban Low-risk delivery centers, Zambia | Before-and-after study,then RCT | WHO ENC Package, including basic resuscitation with bag-mask,taught by demonstration, clinical practice sessions, and performance evaluations; followed by longer in depth training in NRP including bag-mask ventilation and chest compressions | 1) Asphyxia Early Neonatal Mortality (7 d), [not breathing at birth]; 2) Early Neonatal Mortality [first 7 days]; 3) Preterm Mortality [preterm or BW <1500] | Preterm or LBW (< 1500 g) as separate cause of death, though no hierarchy specified for single cause of death | A) 8,148; B) 20,534 | 1) RR 0.56 (NS) 2) RR 0.60 (0.48-0.76) 3) RR 0.74 (NS) |