Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study

BMC Public Health

Table 2 Determinants of total serum homocysteine

	β-Coefficient	95% CI ^d
Sex (0 = men, 1 = women)	-1.341	-1.540	-1.141 ^e
Age (years)	0.136	0.097	0.176 ^e
Alcohol consumption (units/day)	0.098	0.034	0.162 ^e
Smoking status	0.468	0.291	0.645 ^e
Intake of B vitamins	-0.616	-0.904	-0.328 ^e
Use of diuretics	0.394	0.072	0.716 ^e
Body mass index (kg/m²)	-0.019	-0.038	0.001
Systolic blood pressure (mmHg)	0.006	0.001	0.011 ^e
Total serum cholesterol (mmol/L)	0.030	-0.046	0.105
Plasma fasting glucose (mmol/L)	-0.023	-0.096	0.050
Serum uric acid (μmol/L)	0.014	0.009	0.019 ^e
MDRD ^a (ml/min/1.73 m2)	0.037	0.010	0.064 ^e
MDRD × age ^b	-0.0010	-0.0015	-0.0006 ^e
MDRD × uric acid ^c	-0.00011	-0.00016	-0.00005 ^e

^a Modification of Diet in Renal Disease, estimation of glomerular filtration rate
^b Interaction between MDRD and age
^c Interaction between MDRD and serum uric acid
^d 95% Confidence Interval
^e P value < 0.05

ISSN: 1471-2458