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Table 3 Baseline characteristics of completers and non-completers of the 3-dose regimen of the quadrivalent HPV vaccine

From: Factors associated with initiation and completion of the quadrivalent human papillomavirus vaccine series in an ontario cohort of grade 8 girls

Characteristic *

Completers

(N = 1215)

Non-Completers

(N = 210)

Adjusted OR †

(95% CI)

Socio-demographics

   

Age (mean ± SD)

13.2 ± 0.3

13.2 ± 0.3

1.02 (0.60-1.75)

Neighbourhood income quintile

   

   1 (lowest)

16.9

31.0

0.45 (0.28-0.72)††

   2

17.5

17.6

0.80 (0.48-1.33)

   3 (reference)

21.5

17.1

1.00 (reference)

   4

21.0

16.7

0.98 (0.59-1.62)

   5 (highest)

22.7

16.2

1.15 (0.68-1.92)

   Missing‡

0.4

1.4

0.56 (0.12-2.66)

Place of residence

   

   Urban (reference)

77.7

82.4

1.00

   Rural

21.9

16.2

1.76 (1.14-2.74)††

   Missing‡

0.4

1.4

0.56 (0.12-2.66)

Vaccination History

   

MMR

96.8

92.4

1.61 (0.81-3.19)

Meningococcal C

90.0

79.5

1.39 (0.83-2.35)

Hepatitis B

92.3

81.9

1.67 (0.95-2.92)

All three vaccines§

85.1

72.4

1.85 (1.29-2.65)††

Health Services Utilisation

   

Hospitalizations‖

   

   None (reference)

18.8

23.8

1.00

   1

63.1

54.8

1.23 (0.80-1.91)

   2

12.9

13.8

1.08 (0.59-1.98)

   ≥ 3

5.2

7.6

1.04 (0.45-2.37)

Emergency Department visits‖

   

   None (reference)

26.3

23.3

1.00

   1

21.5

21.9

0.85 (0.53-1.35)

   2-7

43.3

43.8

0.88 (0.58-1.35)

   ≥ 8

8.9

11.0

0.73 (0.38-1.40)

Outpatient visits‖

   

   0-13 (reference)

7.6

13.8

1.00

   14-45

41.2

38.1

1.42 (0.79-2.54)

   46-92

40.7

35.7

1.55 (0.83-2.89)

   ≥ 93

10.5

12.4

1.43 (0.67-3.05)

Medical History

   

Previous diagnosis

   

   Infectious and parasitic diseases

14.5

19.1

0.83 (0.48-1.42)

   Intestinal infections

3.2

6.7

0.64 (0.28-1.45)

   Chickenpox

1.5

2.4

0.80 (0.25-2.59)

   Cancer

0.9

1.0

0.80 (0.16-3.98)

   Metabolic disorders

3.0

3.3

1.33 (0.50-3.56)

   Disorders of the immune system

0.1

0.0

-

   Diseases of the blood

1.6

0.5

4.60 (0.56-37.84)

   Mental disorders

0.5

0.5

0.84 (0.09-8.36)

   Epilepsy, seizures, and convulsions

3.1

3.8

0.89 (0.38-2.07)

   Gastroenteritis

5.3

7.1

0.70 (0.36-1.37)

   Nephritis

3.5

5.7

0.62 (0.29-1.30)

   Congenital anomalies

7.0

7.1

0.96 (0.52-1.78)

   Syncope

1.2

1.0

1.62 (0.34-7.77)

   Other serious illness

2.1

1.4

1.66 (0.45-6.14)

Immune-mediated events

   

   Allergic rhinitis

0.3

0.0

-

   Asthma

5.4

6.7

0.89 (0.46-1.75)

   Dermatitis

4.4

3.3

1.72 (0.72-4.14)

Autoimmune diseases

   

   Diabetes mellitus

1.3

1.4

0.77 (0.21-2.83)

   Multiple sclerosis

0.0

0.0

-

   Bell's palsy

0.3

0.0

-

   Guillain-Barré Syndrome

0.0

0.0

-

   Juvenile Arthritis

1.9

3.8

0.58 (0.24-1.41)

   Systemic Lupus Erythematosus

0.0

0.0

-

Risk factors for autoimmune diseases

   

   Cytomegalovirus¶

0.0

0.0

-

   Epstein-Barr virus¶

0.3

0.0

-

   Campylobacter

0.0

0.0

-

   Influenza

15.9

13.3

1.26 (0.80-1.97)

   Mycoplasma pneumoniae

0.1

0.0

-

  1. OR = Odds Ratio; CI = Confidence Interval; SD = Standard deviation; MMR = Measles, mumps and rubella
  2. * Ascertained anytime preceding cohort entry; expressed as percentages (%) unless otherwise indicated.
  3. † Adjusted for all characteristics listed in table as well as vaccination program year.
  4. †† Statistically significant (p < 0.05).
  5. ‡ Missing because postal code in RPDB was either incorrect or unavailable.
  6. § This variable was defined post-hoc and is adjusted for all factors listed except prior use of the MMR, meningococcal C, and hepatitis B vaccines.
  7. ‖ Cut points were based on the frequency distribution of the data for each variable.