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Table 2 Baseline characteristics of girls vaccinated and unvaccinated with the quadrivalent HPV vaccine

From: Factors associated with initiation and completion of the quadrivalent human papillomavirus vaccine series in an ontario cohort of grade 8 girls

Characteristic * Vaccinated
(N = 1425)
Unvaccinated
(N = 1094)
Adjusted OR
(95% CI)
Socio-demographics    
Age (mean ± SD) 13.2 ± 0.3 13.2 ± 0.3 1.10 (0.81-1.50)
Neighbourhood income quintile    
   1 (lowest) 18.9 20.8 0.87 (0.65-1.15)
   2 17.5 18.9 0.80 (0.60-1.06)
   3 (reference) 20.8 18.1 1.00 (reference)
   4 20.4 21.3 0.75 (0.57-0.99)††
   5 (highest) 21.8 19.4 0.91 (0.69-1.19)
   Missing 0.6 1.5 1.34 (0.50-3.61)
Place of residence    
   Urban (reference) 78.4 77.5 1.00 (reference)
   Rural 21.1 21.0 1.14 (0.90-1.43)
   Missing 0.6 1.5 1.34 (0.50-3.61)
Vaccination History    
MMR 96.1 78.9 3.21 (2.25-4.57)††
Meningococcal C 88.5 60.2 2.16 (1.64-2.84)††
Hepatitis B 90.7 62.2 2.86 (2.14-3.83)††
All three vaccines§ 83.2 51.1 4.89 (4.04-5.92)††
Health Services Utilisation    
Hospitalizations    
   None (reference) 19.5 20.4 1.00 (reference)
   1 61.9 59.7 0.82 (0.63-1.07)
   2 13.1 13.6 0.71 (0.50-1.01)
   ≥ 3 5.5 6.3 0.64 (0.38-1.06)
Emergency Department visits    
   None (reference) 25.9 30.2 1.00 (reference)
   1 21.5 22.2 1.00 (0.78-1.28)
   2-7 43.4 38.9 1.16 (0.92-1.46)
   ≥ 8 9.2 8.7 1.13 (0.77-1.66)
Outpatient visits    
   0-13 (reference) 8.5 12.0 1.00 (reference)
   14-45 40.8 42.3 0.91 (0.64-1.31)
   46-92 39.9 37.5 1.07 (0.73-1.57)
   ≥ 93 10.8 8.2 1.31 (0.82-2.11)
Medical History    
Previous diagnosis    
   Infectious and parasitic diseases 15.2 13.9 0.96 (0.70-1.32)
   Intestinal infections 3.7 3.3 1.25 (0.71-2.20)
   Chickenpox 1.6 1.7 0.92 (0.44-1.91)
   Cancer 0.9 0.6 1.55 (0.52-4.60)
   Metabolic disorders 3.0 3.0 0.90 (0.50-1.61)
   Disorders of the immune system 0.1 0.1 2.18 (0.07-73.24)
   Diseases of the blood 1.4 1.6 0.91 (0.42-1.98)
   Mental disorders 0.5 0.7 1.24 (0.38-4.03)
   Epilepsy, seizures, and convulsions 3.2 3.1 1.11 (0.67-1.86)
   Gastroenteritis 5.5 4.3 1.10 (0.71-1.72)
   Nephritis 3.9 3.4 1.24 (0.75-2.04)
   Congenital anomalies 7.0 8.9 0.78 (0.56-1.09)
   Syncope 1.2 1.3 1.05 (0.47-2.35)
   Other serious illness 2.0 1.8 1.05 (0.55-2.00)
Immune-mediated events    
   Allergic rhinitis 0.2 0.4 0.53 (0.10-2.87)
   Asthma 5.6 6.0 0.96 (0.64-1.44)
   Dermatitis 4.3 3.0 1.46 (0.89-2.40)
Autoimmune diseases    
   Diabetes mellitus 1.3 1.7 0.57 (0.28-1.15)
   Multiple sclerosis 0.0 0.1 -
   Bell's palsy 0.2 0.5 0.38 (0.08-1.69)
   Guillain-Barré Syndrome 0.0 0.0 -
   Juvenile Arthritis 2.2 1.7 1.28 (0.66-2.44)
   Systemic Lupus Erythematosus 0.0 0.0 -
Risk factors for autoimmune diseases    
   Cytomegalovirus 0.0 0.1 -
   Epstein-Barr virus 0.2 0.1 4.29 (0.26-71.21)
   Campylobacter 0.0 0.0 -
   Influenza 15.5 13.2 1.13 (0.88-1.46)
   Mycoplasma pneumoniae 0.1 0.1 2.81 (0.09-87.47)
  1. OR = Odds Ratio; CI = Confidence Interval; SD = Standard deviation; MMR = Measles, mumps and rubella
  2. * Ascertained anytime preceding cohort entry; expressed as percentages (%) unless otherwise indicated.
  3. † Adjusted for all characteristics listed in table as well as vaccination program year.
  4. †† Statistically significant (p < 0.05).
  5. ‡ Missing because postal code in RPDB was either incorrect or unavailable
  6. § This variable was defined post-hoc and is adjusted for all factors listed except prior use of the MMR, meningococcal C, and hepatitis B vaccines.
  7. Cut points were based on the frequency distribution of the data for each variable.