|
Analysis*
|
Sample size
|
ΔC (95% CI)
|
ΔE (95% CI)
|
ICUR
|
Distribution in CU-plane
|
|---|
| |
STC
|
CP
| | | |
NE†
|
SE‡
|
SW§
|
NW¶
|
|---|
|
Main
|
260
|
272
|
177 (-293; 678)
|
-0.007 (-0.023; 0.009)
|
-25,440 **
|
10%
|
9%
|
14%
|
67%
|
|
SA1
|
260
|
272
|
186 (-350; 751)
|
-0.007 (-0.023; 0.009)
|
-26,774 **
|
10%
|
9%
|
16%
|
65%
|
|
SA2
|
252
|
260
|
-194 (-295; 751)
|
-0.005 (-0.021; 0.117)
|
-42,569 **
|
17%
|
13%
|
10%
|
59%
|
|
SA3
|
200
|
210
|
41 (-404; 487)
|
0.001 (-0.017; 0.015)
|
-40,939 **
|
20%
|
25%
|
17%
|
38%
|
- * In the main analysis, ΔE = mean difference in QALY, ΔC = mean difference in total costs in which the productivity loss costs were estimated by the FCM; in SA1, ΔC = mean difference in total costs in which the productivity loss costs were estimated by the HCA; SA2 is a repetition of the main analysis in which women who became pregnant a second time during follow-up (N = 20) were excluded; SA3 is a repetition of the main analysis using only the complete cases.
-
† Refers to the northeast quadrant of the CU-plane, which indicates that STC is more effective and more costly than CP.
-
‡ Refers to the southeast quadrant of the CU-plane, which indicates that STC is more effective and less costly than CP.
-
§ Refers to the southwest quadrant of the CU-plane, which indicates that STC is less effective and less costly than CP.
-
¶ Refers to the northwest quadrant of the CU-plane, which indicates that STC is less effective and more costly than CP.
- ** All of these negative incremental cost-utilty ratios (ICURs) were located in the NW quadrant, along with the majority of joint cost-effect pairs, indicating that the STC was less effective and more costly than CP.
