Analysis*
| Sample size | ΔC (95% CI) | ΔE (95% CI) | ICUR | Distribution in CU-plane |
|---|
|  | STC | CP |  |  |  | NEâ€
| SE‡
| SW§
| NW¶
|
|---|
Main | 260 | 272 | 177 (-293; 678) | -0.007 (-0.023; 0.009) | -25,440 ** | 10% | 9% | 14% | 67% |
SA1 | 260 | 272 | 186 (-350; 751) | -0.007 (-0.023; 0.009) | -26,774 ** | 10% | 9% | 16% | 65% |
SA2 | 252 | 260 | -194 (-295; 751) | -0.005 (-0.021; 0.117) | -42,569 ** | 17% | 13% | 10% | 59% |
SA3 | 200 | 210 | 41 (-404; 487) | 0.001 (-0.017; 0.015) | -40,939 ** | 20% | 25% | 17% | 38% |
- * In the main analysis, ΔE = mean difference in QALY, ΔC = mean difference in total costs in which the productivity loss costs were estimated by the FCM; in SA1, ΔC = mean difference in total costs in which the productivity loss costs were estimated by the HCA; SA2 is a repetition of the main analysis in which women who became pregnant a second time during follow-up (N = 20) were excluded; SA3 is a repetition of the main analysis using only the complete cases.
-
†Refers to the northeast quadrant of the CU-plane, which indicates that STC is more effective and more costly than CP.
-
‡ Refers to the southeast quadrant of the CU-plane, which indicates that STC is more effective and less costly than CP.
-
§ Refers to the southwest quadrant of the CU-plane, which indicates that STC is less effective and less costly than CP.
-
¶ Refers to the northwest quadrant of the CU-plane, which indicates that STC is less effective and more costly than CP.
- ** All of these negative incremental cost-utilty ratios (ICURs) were located in the NW quadrant, along with the majority of joint cost-effect pairs, indicating that the STC was less effective and more costly than CP.
