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Table 2 Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for allergic disorders according to the number of siblings in 1745 pregnant women, Kyushu Okinawa Maternal and Child Health Study, Japan1

From: Sibling number and prevalence of allergic disorders in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study

  Wheeze Asthma Eczema Rhinoconjunctivitis
  Prevalence OR (95% CI) Prevalence OR (95% CI) Prevalence OR (95% CI) Prevalence OR (95% CI)
Total siblings        
0 (n = 94) 9.6% 1.00 5.3% 1.00 11.7% 1.00 26.6% 1.00
1 (n = 788) 11.0% 1.07 (0.53-2.40) 5.3% 0.94 (0.39-2.82) 11.8% 0.84 (0.45-1.74) 27.0% 0.87 (0.54-1.46)
2 (n = 688) 9.9% 0.88 (0.43-1.99) 5.7% 0.92 (0.37-2.78) 13.4% 0.94 (0.49-1.94) 25.3% 0.79 (0.48-1.32)
≥ 3 (n = 175) 10.3% 0.75 (0.32-1.87) 5.7% 0.72 (0.24-2.45) 17.1% 1.31 (0.63-2.92) 22.9% 0.75 (0.42-1.38)
   P for trend 0.18   0.55   0.18   0.23
Older siblings        
0 (n = 829) 10.7% 1.00 5.1% 1.00 12.7% 1.00 29.0% 1.00
1 (n = 622) 11.1% 1.02 (0.72-1.44) 6.6% 1.22 (0.77-1.93) 12.5% 1.03 (0.74-1.41) 22.8% 0.71 (0.56-0.91)
≥ 2 (n = 294) 8.2% 0.74 (0.45-1.20) 4.4% 0.79 (0.40-1.49) 14.6% 1.33 (0.89-1.98) 23.8% 0.77 (0.56-1.06)
   P for trend 0.34   0.77   0.21   0.03
Younger siblings        
0 (n = 695) 9.8% 1.00 5.9% 1.00 12.8% 1.00 23.6% 1.00
1 (n = 695) 11.1% 1.07 (0.75-1.53) 4.5% 0.72 (0.44-1.17) 11.7% 0.78 (0.56-1.09) 27.8% 1.22 (0.95-1.56)
≥ 2 (n = 355) 10.4% 0.90 (0.57-1.39) 6.8% 1.02 (0.59-1.75) 15.8% 1.09 (0.74-1.58) 26.8% 1.18 (0.87-1.59)
   P for trend 0.71   0.86   0.91   0.21
  1. 1 Adjustment for age, region of residence, pack-years of smoking, secondhand smoke exposure at home and at work, family history of asthma, atopic eczema, and allergic rhinitis, household income, and education.