|  |  | Total | Excluding cases within 5 years | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 |  | Person-years | No. of cases | HR*1 (95% CI*) | P | HR2 (95% CI) | P | No. of cases | HR2 (95% CI) | P |
Men | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 |  |  | Total cancer |  |  |  | ||||
 | Never use | 220,948 | 2152 | 1.00 (reference) |  | 1.00 (reference) |  | 1210 | 1.00 (reference) |  |
 | Past use | 28,863 | 324 | 0.98 (0.87-1.10) | 0.8 | 0.98 (0.87-1.10) | 0.8 | 167 | 0.95 (0.80-1.11) | 0.5 |
 | Recent use | 9603 | 102 | 1.00 (0.82-1.22) | 0.97 | 1.01 (0.83-1.23) | 0.9 | 59 | 1.05 (0.80-1.36) | 0.7 |
 | Consistent use | 10,863 | 139 | 1.11 (0.94-1.32) | 0.2 | 1.10 (0.93-1.31) | 0.3 | 75 | 1.13 (0.89-1.43) | 0.3 |
 |  |  | Cardiovascular disease |  |  |  | ||||
 | Never use | 203,013 | 934 | 1.00 (reference) |  | 1.00 (reference) |  | 490 | 1.00 (reference) |  |
 | Past use | 26,639 | 125 | 0.91 (0.75-1.09) | 0.3 | 0.89 (0.73-1.07) | 0.2 | 61 | 0.86 (0.66-1.12) | 0.3 |
 | Recent use | 8889 | 31 | 0.71 (0.50-1.02) | 0.06 | 0.72 (0.51-1.04) | 0.08 | 15 | 0.66 (0.39-1.10) | 0.1 |
 | Consistent use | 10,059 | 53 | 1.03 (0.78-1.36) | 0.8 | 1.02 (0.77-1.35) | 0.9 | 28 | 1.04 (0.71-1.53) | 0.8 |
Women | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 |  |  | Total cancer |  |  |  | ||||
 | Never use | 248,659 | 1299 | 1.00 (reference) |  | 1.00 (reference) |  | 698 | 1.00 (reference) |  |
 | Past use | 44,237 | 287 | 1.19 (1.04-1.35) | 0.01 | 1.17 (1.02-1.33) | 0.02 | 157 | 1.21 (1.01-1.44) | 0.04 |
 | Recent use | 15,217 | 101 | 1.25 (1.02-1.53) | 0.03 | 1.24 (1.01-1.52) | 0.04 | 56 | 1.26 (0.96-1.66) | 0.1 |
 | Consistent use | 18,892 | 97 | 0.94 (0.76-1.16) | 0.6 | 0.92 (0.75-1.13) | 0.4 | 47 | 0.82 (0.61-1.11) | 0.2 |
 |  |  | Cardiovascular disease |  |  |  | ||||
 | Never use | 227,570 | 530 | 1.00 (reference) |  | 1.00 (reference) |  | 262 | 1.00 (reference) |  |
 | Past use | 40,586 | 116 | 1.11 (0.91-1.36) | 0.3 | 1.08 (0.88-1.32) | 0.5 | 63 | 1.24 (0.94-1.64) | 0.1 |
 | Recent use | 13,918 | 43 | 1.30 (0.95-1.77) | 0.1 | 1.32 (0.97-1.81) | 0.08 | 20 | 1.26 (0.80-1.99) | 0.3 |
 | Consistent use | 17,309 | 26 | 0.60 (0.40-0.89) | 0.01 | 0.60 (0.41-0.89) | 0.01 | 14 | 0.70 (0.41-1.21) | 0.2 |