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Table 2 Odds ratios (ORs) and 95% confidence intervals (CIs) for eczema and rhinoconjunctivitis in relation to dietary intake of polyunsaturated fatty acids in 23,388 schoolchildren, Ryukyus Child Health Study, Japan

From: Polyunsaturated fatty acid intake and prevalence of eczema and rhinoconjunctivitis in Japanese children: The Ryukyus Child Health Study

 

Eczema

Rhinoconjunctivitis

Variable1

Prevalence (%)

Crude OR (95% CI)

Adjusted OR (95% CI)2

Prevalence (%)

Crude OR (95% CI)

Adjusted OR (95% CI)2

Polyunsaturated fatty acids

      

   Q1 (10.7)

6.1

1.00

1.00

8.8

1.00

1.00

   Q2 (12.8)

6.8

1.13 (0.96-1.34)

1.10 (0.94-1.31)

7.6

0.86 (0.74-0.99)

0.86 (0.74-0.999)

   Q3 (14.2)

7.7

1.29 (1.10-1.51)

1.23 (1.05-1.45)

7.2

0.81 (0.69-0.94)

0.81 (0.70-0.95)

   Q4 (15.6)

6.5

1.08 (0.92-1.28)

1.02 (0.86-1.21)

7.9

0.89 (0.77-1.03)

0.89 (0.77-1.04)

   Q5 (18.0)

7.9

1.33 (1.13-1.56)

1.26 (1.07-1.48)

8.6

0.98 (0.85-1.13)

0.97 (0.83-1.12)

P for trend

 

0.005

0.04

 

0.96

0.83

n-3 Polyunsaturated fatty acids

      

   Q1 (1.3)

5.8

1.00

1.00

8.1

1.00

1.00

   Q2 (1.7)

6.9

1.20 (1.02-1.42)

1.16 (0.98-1.37)

8.2

1.01 (0.87-1.17)

1.01 (0.87-1.17)

   Q3 (2.0)

7.4

1.30 (1.10-1.53)

1.22 (1.04-1.45)

7.1

0.87 (0.75-1.01)

0.87 (0.74-1.01)

   Q4 (2.3)

6.9

1.21 (1.02-1.42)

1.12 (0.94-1.32)

8.1

1.00 (0.86-1.16)

0.99 (0.85-1.15)

   Q5 (2.8)

7.9

1.40 (1.19-1.64)

1.31 (1.11-1.54)

8.6

1.07 (0.93-1.24)

1.05 (0.90-1.22)

P for trend

 

0.0003

0.009

 

0.45

0.63

α-Linolenic acid (18:3 n-3)

      

   Q1 (1.0)

5.8

1.00

1.00

8.6

1.00

1.00

   Q2 (1.3)

6.7

1.17 (0.99-1.39)

1.14 (0.96-1.35)

8.0

0.93 (0.80-1.08)

0.93 (0.80-1.08)

   Q3 (1.5)

7.5

1.32 (1.12-1.56)

1.25 (1.06-1.47)

7.2

0.82 (0.71-0.95)

0.82 (0.71-0.96)

   Q4 (1.8)

7.1

1.24 (1.05-1.46)

1.15 (0.97-1.36)

8.1

0.94 (0.81-1.09)

0.94 (0.81-1.09)

   Q5 (2.2)

8.0

1. 41 (1.20-1.66)

1.31 (1.12-1.55)

8.2

0.95 (0.82-1.10)

0.93 (0.80-1.08)

P for trend

 

< 0.0001

0.003

 

0.57

0.41

Eicosapentaenoic acid (20:5 n-3)

      

   Q1 (0.03)

6.4

1.00

1.00

8.3

1.00

1.00

   Q2 (0.07)

6.8

1.06 (0.90-1.25)

1.04 (0.88-1.23)

7.8

0.94 (0.81-1.10)

0.95 (0.82-1.11)

   Q3 (0.09)

7.1

1.10 (0.94-1.30)

1.07 (0.91-1.26)

7.6

0.92 (0.79-1.06)

0.91 (0.78-1.06)

   Q4 (0.12)

7.5

1.18 (1.002-1.38)

1.15 (0.98-1.35)

7.5

0.90 (0.78-1.05)

0.90 (0.77-1.05)

   Q5 (0.21)

7.2

1.13 (0.96-1.33)

1.12 (0.95-1.31)

8.9

1.09 (0.94-1.26)

1.10 (0.95-1.27)

P for trend

 

0.06

0.09

 

0.41

0.42

Docosahexaenoic acid (22:6 n-3)

      

   Q1 (0.13)

6.9

1.00

1.00

8.5

1.00

1.00

   Q2 (0.20)

6.6

0.95 (0.81-1.12)

0.94 (0.80-1.11)

7.6

0. 89 (0.76-1.03)

0. 90 (0.77-1.05)

   Q3 (0.24)

7.5

1.08 (0.93-1.27)

1.04 (0.88-1.21)

7.6

0.88 (0.76-1.02)

0.86 (0.74-0.998)

   Q4 (0.30)

7.0

1.01 (0.86-1.18)

0.99 (0.84-1.16)

7.9

0.92 (0.79-1.06)

0.92 (0.79-1.06)

   Q5 (0.43)

7.0

1.01 (0.86-1.19)

1.01 (0.86-1.18)

8.5

1.00 (0.87-1.16)

1.00 (0.86-1.16)

P for trend

 

0.67

0.75

 

0.85

0.92

n-6 Polyunsaturated fatty acids

      

   Q1 (7.1)

6.1

1.00

1.00

8.6

1.00

1.00

   Q2 (8.8)

6.8

1.12 (0.95-1.32)

1.07 (0.91-1.27)

7.9

0.91 (0.78-1.05)

0.91 (0.78-1.05)

   Q3 (10.1)

7.2

1.19 (1.01-1.40)

1.14 (0.96-1.34)

7.7

0.88 (0.76-1.02)

0.90 (0.77-1.05)

   Q4 (11.3)

7.0

1.15 (0.97-1.35)

1.08 (0.91-1.27)

7.5

0.86 (0.74-1.001)

0.87 (0.75-1.02)

   Q5 (13.5)

8.0

1.33 (1.13-1.56)

1.26 (1.07-1.48)

8.5

0.99 (0.86-1.15)

0.98 (0.85-1.14)

P for trend

 

0.001

0.01

 

0.71

0.68

Linoleic acid (18:2 n-6)

      

   Q1 (6.9)

6.1

1.00

1.00

8.6

1.00

1.00

   Q2 (8.7)

6.8

1.12 (0.95-1.32)

1.08 (0.91-1.27)

7.9

0.91 (0.78-1.05)

0.91 (0.79-1.06)

   Q3 (9.9)

7.2

1.20 (1.02-1.41)

1.14 (0.97-1.34)

7.5

0.86 (0.74-1.002)

0.88 (0.76-1.03)

   Q4 (11.1)

6.9

1.13 (0.96-1.33)

1.06 (0.90-1.26)

7.5

0.86 (0.74-0.999)

0.87 (0.75-1.02)

   Q5 (13.3)

8.0

1.34 (1.14-1.57)

1.27 (1.08-1.49)

8.6

1.00 (0.87-1.16)

1.00 (0.86-1.15)

P for trend

 

0.001

0.01

 

0.77

0.76

Arachidonic acid (20:4 n-6)

      

   Q1 (0.07)

7.9

1.00

1.00

8.9

1.00

1.00

   Q2 (0.10)

7.5

0.95 (0.81-1.10)

0.92 (0.78-1.07)

7.8

0.87 (0.75-1.01)

0.88 (0.76-1.02)

   Q3 (0.12)

6.7

0.83 (0.71-0.98)

0.80 (0.68-0.94)

8.2

0.92 (0.79-1.06)

0.91 (0.78-1.05)

   Q4 (0.14)

6.3

0.79 (0.67-0.92)

0.76 (0.65-0.89)

7.5

0.84 (0.72-0.97)

0.83 (0.72-0.97)

   Q5 (0.17)

6.6

0.83 (0.71-0.97)

0.81 (0.69-0.95)

7.8

0.87 (0.75-1.01)

0.86 (0.74-0.997)

P for trend

 

0.002

0.0008

 

0.05

0.03

n-3/n-6 Polyunsaturated fatty acid ratio

      

   Q1 (0.17)

6.0

1.00

1.00

7.4

1.00

1.00

   Q2 (0.18)

7.1

1.20 (1.02-1.41)

1.17 (0.99-1.38)

7.8

1.06 (0.91-1.23)

1.05 (0.90-1.23)

   Q3 (0.20)

7.0

1.18 (0.997-1.39)

1.14 (0.96-1.34)

8.1

1.10 (0.94-1.28)

1.07 (0.92-1.25)

   Q4 (0.21)

7.6

1.28 (1.09-1.51)

1.21 (1.03-1.42)

8.0

1.08 (0.93-1.26)

1.04 (0.89-1.21)

   Q5 (0.23)

7.2

1.21 (1.03-1.43)

1.17 (0.99-1.38)

8.7

1.19 (1.03-1.38)

1.16 (0.99-1.35)

P for trend

 

0.02

0.07

 

0.03

0.11

  1. 1 Quintile medians in g/day adjusted energy intake using the residual method are given in parentheses, except for the ratio of n-3 to n-6 polyunsaturated fatty acids, which was based on crude intake in g/day.
  2. 2 Adjustment for age, sex, residential municipality, number of siblings, smoking in the household, body mass index, paternal and maternal history of allergic diseases, and paternal and maternal educational level.