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Table 1 Methodological differences between AusDiab and DRUID studies

From: High rates of albuminuria but not of low eGFR in Urban Indigenous Australians: the DRUID Study

Measure AusDiab DRUID
Blood Pressure Dinamap semi-automatic oscillometric recorder Welch Allyn Spot Vital signs monitor
HbA1c* Boronate affinity high-performance liquid chromatography (BioRad Variant Haemoglobin Testing System, BioRad, Hercules, CA, USA) Percentage of total haemoglobin after separation by ion-exchange chromatography on a Pharmacia Mono-S column (results traceable to DCCT method)
Serum creatinine Modified Jaffe reaction (Olympus AU600 auto-analyser)** Kinetic Jaffe (Hitachi 917)
eGFR Estimated from calibrated serum creatinine values, using the "175" MDRD equation Estimated from pre-IDMS creatinine values, using "186" MDRD equation
Urine albumin Immunonephelometry (Beckman Array) Immunonephelometry (Beckman array 360)
Urine creatinine Modified Jaffe reaction (Olympus AU600 auto-analyser) Kinetic Jaffe (Hitachi 917)
CRP Data unavailable, therefore CRP not included in comparative model  
  1. * Comparison of 53 samples by both HbA1c methods: mean HbA1c 5.94% (Pharmacia) vs 6.33% (BioRad), r = 0.972, p < 0.001, Bland-Altman mean difference 0.396 (95%CI 0.309-0.483), p = 0.027 (Pitman's).
  2. **subsequent calibration to IDMS method by re-assaying a stored sub sample (n = 241)