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Table 1 Model parameters, estimates, and lower and upper limits

From: Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination - United States, 2001-2010

Parameter

Definition

Lower Limit

Estimate

Upper Limit

α

Vaccine era CRS incidence (cases per 10,000 live births)a, b

-

0.00

-

β

Pre-vaccine era CRS incidence (cases per 10,000 live births)c

2.0

4.0

15

γ

Live births per year (rounded to the nearest 1000)b, d

-

4,150,000

-

δ

Percentage of CRS cases presenting with an ASD

3.0%

7.4%

10.0%

  1. All data are from the United States unless otherwise specified in Methods.
  2. a Averaged over 2001-2008.
  3. b Parameter was not varied in sensitivity analyses (no lower and upper limit given).
  4. c Lower limit, upper limit, and estimate correspond to endemic, epidemic, and overall CRS incidence, respectively.
  5. d Averaged over 2001-2009.