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Table 3 Risk of incident myocardial infarction by number of cigarettes per day (cig/day), tar and nicotine yield per cigarette (mg/cig) and tar and nicotine intake per day (mg/day) in men: Hazard ratio (HR) and 95% confidence interval (95% CI)

From: Association of daily tar and nicotine intake with incident myocardial infarction: Results from the population-based MONICA/KORA Augsburg Cohort Study 1984 - 2002

Smoking habits Number of
participants
(N)
Number of
events
(N)
Age- and survey-adjusted
model*
HR (95% CI)
MI risk factor-adjusted
model+
HR (95% CI)
Never-smokers++ 1,181 53 1.00 1.00
Ex-smokers 1,532 117 1.31 (0.94-1.81) 1.26 (0.90-1.75)
Occasional smokers 141 7 1.14 (0.52-2.50) 1.15 (0.52-2.53)
Regular smokers     
   Number of cigarettes smoked per day     
Light smokers (1 - 19 cig/day) 503 54 2.54 (1.74-3.71) 2.34 (1.60-3.43)
Heavy smokers (≥ 20 cig/day) 742 76 3.13 (2.20-4.45) 2.71 (1.88-3.89)
   Tar yield per cigarette#     
1 - 12 mg/cig 274 29 2.21 (1.40-3.47) 2.05 (1.30-3.24)
≥ 13 mg/cig 971 101 3.12 (2.23-4.36) 2.73 (1.94-3.84)
   Nicotine yield per cigarette#     
0.1 - 0.7 mg/cig 229 26 2.36 (1.48-3.78) 2.20 (1.37-3.52)
≥ 0.8 mg/cig 1,016 104 3.01 (2.16-4.19) 2.64 (1.88-3.71)
   Tar intake per day#     
1 - 129 mg/day 236 27 2.36 (1.48-3.75) 2.24 (1.40-3.56)
130 - 259 mg/day 350 33 2.36 (1.53-3.65) 2.12 (1.37-3.29)
≥ 260 mg/day 659 70 3.49 (2.43-5.01) 3.01 (2.08-4.36)
   Nicotine intake per day#     
1 - 8 mg/day 290 34 2.46 (1.60-3.78) 2.33 (1.51-3.59)
9 - 16 mg/day 418 38 2.38 (1.57-3.61) 2.11 (1.38-3.21)
≥ 17 mg/day 537 58 3.68 (2.53-5.36) 3.16 (2.15-4.65)
  1. ++ Reference category, * Model was adjusted for age (continuous) and survey (S1 or S2), model was additionally adjusted for alcohol consumption per day (0, 1-39, ≥ 40 g/day), actual hypertension (yes or no), total cholesterol/HDL-C ratio (<3.0, 3.0-5.4, ≥ 5.5), physical inactivity (yes or no) and diabetes (no or yes), # HRs and 95% CIs for ex- and occasional smokers from model including number of cigarettes smoked per day are displayed. The respective estimates in the models including tar yield, nicotine yield, tar or nicotine intake differ slightly and are almost equal.