Association of daily tar and nicotine intake with incident myocardial infarction: Results from the population-based MONICA/KORA Augsburg Cohort Study 1984 - 2002

Table 3 Risk of incident myocardial infarction by number of cigarettes per day (cig/day), tar and nicotine yield per cigarette (mg/cig) and tar and nicotine intake per day (mg/day) in men: Hazard ratio (HR) and 95% confidence interval (95% CI)

Smoking habits	Number of participants (N)	Number of events (N)	Age- and survey-adjusted model* HR (95% CI)	MI risk factor-adjusted model⁺ HR (95% CI)
Never-smokers⁺⁺	1,181	53	1.00	1.00
Ex-smokers	1,532	117	1.31 (0.94-1.81)	1.26 (0.90-1.75)
Occasional smokers	141	7	1.14 (0.52-2.50)	1.15 (0.52-2.53)
Regular smokers
Number of cigarettes smoked per day
Light smokers (1 - 19 cig/day)	503	54	2.54 (1.74-3.71)	2.34 (1.60-3.43)
Heavy smokers (≥ 20 cig/day)	742	76	3.13 (2.20-4.45)	2.71 (1.88-3.89)
Tar yield per cigarette^#
1 - 12 mg/cig	274	29	2.21 (1.40-3.47)	2.05 (1.30-3.24)
≥ 13 mg/cig	971	101	3.12 (2.23-4.36)	2.73 (1.94-3.84)
Nicotine yield per cigarette^#
0.1 - 0.7 mg/cig	229	26	2.36 (1.48-3.78)	2.20 (1.37-3.52)
≥ 0.8 mg/cig	1,016	104	3.01 (2.16-4.19)	2.64 (1.88-3.71)
Tar intake per day^#
1 - 129 mg/day	236	27	2.36 (1.48-3.75)	2.24 (1.40-3.56)
130 - 259 mg/day	350	33	2.36 (1.53-3.65)	2.12 (1.37-3.29)
≥ 260 mg/day	659	70	3.49 (2.43-5.01)	3.01 (2.08-4.36)
Nicotine intake per day^#
1 - 8 mg/day	290	34	2.46 (1.60-3.78)	2.33 (1.51-3.59)
9 - 16 mg/day	418	38	2.38 (1.57-3.61)	2.11 (1.38-3.21)
≥ 17 mg/day	537	58	3.68 (2.53-5.36)	3.16 (2.15-4.65)

++ Reference category, * Model was adjusted for age (continuous) and survey (S1 or S2), model was additionally adjusted for alcohol consumption per day (0, 1-39, ≥ 40 g/day), actual hypertension (yes or no), total cholesterol/HDL-C ratio (<3.0, 3.0-5.4, ≥ 5.5), physical inactivity (yes or no) and diabetes (no or yes), # HRs and 95% CIs for ex- and occasional smokers from model including number of cigarettes smoked per day are displayed. The respective estimates in the models including tar yield, nicotine yield, tar or nicotine intake differ slightly and are almost equal.

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