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Table 2 Risk factors for relapse, failure, or default from initial TB treatment, a subgroup analysis.

From: Risk factors for tuberculosis treatment failure, default, or relapse and outcomes of retreatment in Morocco

Subgroup
Risk factor
Univariate analysis
(OR, 95% CI)
Multivariate analysis
(OR, 95% CI)
Relapse (N = 35)
   Lack of sputum smear conversion to negative by 3 months 4.58 (2.22-9.43) 4.14 (1.92-9.01)
   Missed doses during the intensive phase 3.23 (0.96-10.9) NS
Treatment failure (N = 18)
   Lack of sputum smear conversion to negative by 3 months ** **
   Comorbid conditions 3.29 (1.08-9.99) NS
Treatment default (N = 27)
   Male gender 6.50 (1.51-28.1) 4.56 (0.96-20.7)
   Substance use† 4.19 (1.83-9.56) 2.73 (1.04-7.15)
   Missed doses during the intensive phase 12.9 (4.65-35.7) 10.9 (3.47-34.0)
   Hospitalization during treatment 2.56 (1.04-6.23) 3.84 (1.41-10.5)
  1. ** Three-month sputum smear conversion to negative was negative in all failure patients so could not be included in logistic regression models.
  2. †Tobacco, alcohol, or illicit drug use.