Table 3 Data collection methods and main study variables in ESCARVAL-RISK study.

Mortality register, Hospital dropouts database, electronic clinical record ICD diagnoses.

Cause of death (All, Cardiovascular or not) Cardiovascular Morbidity:

ICD-9 codes

   - Ischemic heart disease

402.9; 404.9, 410-414

   - Stroke.

430-438, 444

   - Peripheral Vascular Disease.

440.2, 443.8, 444, 445, 447.9

   - Aortic aneurysm.

441

   - Heart failure.

428, 398.91

   - Atrial fibrillation.

427.3

   - Chronic renal insufficiency.

585.5, 585.6, 588.88, 593.9 791.0

   - Proteinuria.

   - Essential hypertension.

401, 403, 404, 405, 405.1, 405.11, 405.19, 997, 997.91, 401.0, 401.1, 401.9

   - Diabetes mellitus.

250.0, 250.4, 362.0, 583.81, 581.81, 250.6, 250.5

   - Hypercholesterolemia/hyperlipidemia.

272.0, 272.2

   - Metabolic syndrome.

277.7

   - Overweight and obesity.

278

   - Retinopathy.

362.0, 362.11, 362.12, 362.81, 362.82, 363.41, 362.83.

Electronic clinical record abstraction of patients' characteristics or measurements performed on patients during the medical visits

Patients' demographic and psychosocial characteristics

Relevant family medical history: early cardiovascular event

CVD risk factors related to lifestyle (tobacco smoking, physical activity)

Weight, height, waist and hip circumference, and blood pressure, under standardized conditions. Left ventricular hypertrophy (Cornell criteria). Microalbuminuria (30-300 mg/g). Comorbidity

   - Current medication: antihypertensives, statins and other lipid-lowering drugs, oral

   - antidiabetics, insulin, anticoagulants, aspirin, and combination drug therapy

Laboratory results taken from the clinical record (most recent blood data and physical examination during the previous year)

Total cholesterol, LDL cholesterol, HDL cholesterol, non-HDL cholesterol, triglycerides, apolipoprotein B, blood pressure, glucose, hemoglobine-A1c, creatinine, glomerular filtration rate (MDRD), fibrinogen (mg/dl), uric acid.