Skip to main content

Table 5 Comparison of selected effect estimates 1 year after the intervention (among studies meta-analysed and not meta-analysed)

From: Reduction of diabetes risk in routine clinical practice: are physical activity and nutrition interventions feasible and are the outcomes from reference trials replicable? A systematic review and meta-analysis

Author, year, reference # Study
Type
Effect size for weight* % achieving a) ≥ 7% or
b) ≥ 5% weight loss
% Reduction in diabetes incidence Effect size for FPG mmol/L Effect size for 2-hr OGTT mmol/L Effect for waist circumference (cm) Effect on fat intake as % of total energy Effect on fibre intake g/day
Reference Trials          
DPP Research Group, 2002 [1] RCT -5.6 Kg a) 49% NR§ -0.3 NR NR -6.6% NR
Finnish DPS [5] RCT -4.2 Kg b) 43% NR§ -0.1 -0.8 -4.4 -21% -12%
Meta-Analysed Trials          
Barclay, 2008 [87]** RCT -2.7 Kg   NR -0.02 NR -6.01 NR NR
Bo, 2007 [48] RCT -0.75 Kg   NR -0.26 NR -2.55 NR +1.7
Kosaka, 2005 [49] RCT -2.5 Kg   0.5% NR@1 yr NR NR NR NR
Dyson, 1997 [50] RCT -0.5 Kg   NR -0.1 +0.4 NR -3.5% +0.9
Studies Not Meta-Analysed          
Greaves, 2008 [86] RCT -0.3 Kg b) 24% NR NR NR -1.6 NR NR
Torgerson, 2004 [80]** RCT -6.2 Kg   NR + 0.2 - 0.4 -7.0 NR NR
Whittemore, 2009 [78]*** ClustRCT -1.5 Kg b) 25% NR NR NR NR NR NR
McTigue, 2009 [84] BAC - 5.2 Kg a) 27% NR NR NR NR NR NR
Eriksson, 1991 [79] BAC -5.0 Kg   -37% NR -1.5 NR NR NR
Pagoto, 2008 [14] B-A -5.5 Kg a) 30% NR NR NR NR NR NR
Laatikainen, 2007 [83] B-A -2.5 Kg   -23% - 0.14 - 0.58 -4.2 NR NR
Absetz, 2005 & 2009 [77, 82] B-A -1.0 Kg   NR + 0.15 0.0 -1.2 in F
+2.3 in M
NR 52% met goal
  1. NR = not reported
  2. References to a) or b) indicate comparison to US DPP or Finnish DPS respectively
  3. * values presented for B-A studies are changes from before to after intervention; values for RCT are differences in change before and after the intervention in the 'lifestyle treatment' group only
  4. § cumulated diabetes incidence reduction (~58%) reported over 4 and 6 years (US DPP & Finish DPS, respectively)
  5. ** values presented as before-after for the lifestyle + placebo group only (excludes effects of medication arm)
  6. *** estimates at 6 months