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Table 3 Risk of incident cardiovascular disease associated to hypercholesterolemia and hypertension in a cohort of adult population from Murcia (south-east Spain)

From: Cardiovascular risk estimated after 13 years of follow-up in a low-incidence Mediterranean region with high-prevalence of cardiovascular risk factors

  Ischemic heart disease Stroke All events
  Angina AMI All ischemic events     
  Py/cases HR (95%CI) Py/cases HR 95%CI Py/cases HR 95%CI Py/cases HR 95%CI Py/cases HR 95%CI
Hypercholesterolemia a           
No 19194/12 1 19213/10 1 19170/19 1 19288/20 1 19113/37 1
Controlled 2609/5 1,22 (0,39-3,81) 2629/4 1,30 (0,39-4.37) 2606/7 1,18 (0,47-2,96) 2676/7 1,44 (0,56-3,67) 2578/11 1,08 (0,53-2,24)
Uncontrolled 3814/16 2,20 (0.94-5.16) 3813/22 3,57 (1,57-8.12) 3757/29 2,83 (1,49-5,37) 3913/9 1,08 (0,45-2,60) 3724/32 1.89 (1,11-3,23)
      P heterogneity by sex = 0.789 P heterogneity by sex = 0.097 P heterogneity by sex = 0.217
Hypertension b          
No 16631/7 1 16633/7 1 16614/12 1 16683/9 1 16580/18 1
Controlled 2043/4 3,32 (0,89-12,36) 2069/2 1,80 (0,36-9,17) 2040/5 2,71 (0,90-8,12) 2126/4 1,98 (0,56-6.98) 2037/7 2,22 (0,89-5,54)
Uncontrolled 7238/23 2,78 (1,10-7,08) 7248/28 4,06 (1,64-10.03) 7172/40 3,15 (1,55-6,40) 7341/24 2,31 (0.98-5,43) 7070/56 2,85 (1,60-5,06)
      P heterogneity by sex = 0.030 P heterogneity by sex = 0.995 P heterogneity by sex = 0.053
  1. AMI: Acute myocardial infarction; Py: Person-years. HR: Hazard ratio. CI: confidence interval.
  2. aControlled hypercholesterolemia defined as prior diagnosis of hypercholesterolemia or use of lipid-lowering medication and total serum cholesterol <240 mg/dl; uncontrolled hypercholesterolemia defined as total serum cholesterol ≥240 mg/dl.
  3. bControlled hypertension defined as prior diagnosis of hypertension or use of anti-hypertensive medication and systolic/diastolic blood pressure <140/90 mmHg; uncontrolled hypertension defined as systolic/diastolic blood pressure ≥140/90 mmHg.