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Table 2 Risk of incident cardiovascular disease in a cohort of adult population from Murcia (south-east Spain)

From: Cardiovascular risk estimated after 13 years of follow-up in a low-incidence Mediterranean region with high-prevalence of cardiovascular risk factors

  Ischemic heart disease Stroke All events
  Angina AMI All ischemic events     
  Py/cases HR (95% CI) Py/cases HR (95% CI) Py/cases HR (95% CI) Py/cases HR (95% CI) Py/cases HR (95% CI)
Total cholesterol (mg/dl)           
<200 15393/10 1 15404/8 1 15381/16 1 15454/19 1 15308/31 1
200-239 7154/8 1.14 (0.43-3.05) 7182/7 0.83 (0.29-2.39) 7138/12 0.97 (0.44-2.11) 7232/9 0.54 (0.23-1.28) 7104/18 0.71 (0.39-1.29)
≥240 3814/16 2.27 (0.91-5.68) 3813/22 2.85 (1.16-6.99) 3757/29 2.59 (1.30-5.14) 3913/9 0.79 (0.33-1.90) 7105/32 1.61 (0.92-2.81)
P for trend (categorical)   P = 0.075   P = 0.009   P = 0.005   P = 0.459   P = 0.119
      P heterogneity by sex = 0.071 P heterogneity by sex = 0.500 P heterogneity by sex = 0.024
Triglycerides (mg/dl)           
<150 20902/17 1 20947/14 1 20868/28 1 21041/26 1 20768/44 1
≥150 5459/17 1.64 (0.77-3.50) 5452/23 2.48 (1.17-5.27) 5408/29 1.64 (0.91-2.94) 5558/11 0.83 (0.39-1.79) 5369/37 1.52 (0.94-2.47)
      P heterogneity by sex = 0.035 P heterogneity by sex = 0.003 P heterogneity by sex = 0.009
Blood pressure (mm Hg)          
<140/90 19212/12 1 19151/9 1 19103/17 1 19258/13 1 19067/25 1
≥140/90   2.12 (0.95-4.71) 7248/28 3.68 (1.62-8.34) 7172/40 2.59 (1.39-4.84) 7341/24 1.92 (0.91-4.01) 7070/56 2.44 (1.46-4.07)
      P heterogneity by sex = 0.040 P heterogneity by sex = 0.964 P heterogneity by sex = 0.101
Diabetes a           
No 23620/23 1 23627/28 1 23553/40 1 23820/29 1 23449/61 1
Yes 2179/9 2.04 (0.95-4.71) 2199/9 1.77 (0.79-3.97) 2162/15 1.98 (1.02-3.83) 2216/7 1.45 (0.60-3.47) 2135/18 1.67 (0.96-2.92)
      P heterogneity by sex = 0.004 P heterogneity by sex = 0.483 P heterogneity by sex = 0.010
Ever smoking           
No 13623/15 1 13660/13 1 13597/21 1 13723/16 1 13526/32 1
Yes 2070/19 1.93 (0.78-4.74) 12739/24 1.94 (0.84-4.51) 12679/36 2.22 (1.10-4.46) 12875/21 3.88 (1.31-11.50) 12610/49 2.39 (1.31-4.38)
      P heterogneity by sex = 0.010 P heterogneity by sex = 0.716 P heterogneity by sex = 0.030
BMI categories b           
Normal weight 9328/4 1 9324/5 1 9317/7 1 9387/4 1 9306/10 1
Overweight 11221/18 1.07 (0.33-3.41) 11232/24 0.82 (0.29-2.33) 1176/33 1.06 (0.44-2.52) 11346/16 2.61 (0.72-9.42) 11114/43 1.29 (0.62-2.66)
Obese 5811/12 0.91 (0.26-3.18) 5843/8 0.38 (0.11-1.27) 5783/17 0.76 (0.29-1.99) 5866/17 2.56 (0.69-9.48) 5717/28 1.08 (0.50-2.34)
P for trend (categorical)   P = 0.801   P = 0.065   P = 0.455   P = 0.216   P = 0.950
      -c -c -c
  1. AMI: Acute myocardial infarction; Py: Person-years. HR: Hazard ratio. CI: confidence interval.
  2. Cox models adjusted by all variables in the table, plus educational level and physical activity of moderate and high intensity, and stratified by sex and age.
  3. aDefined as a self-reported diagnosis of diabetes or prescription of insulin or oral anti-diabetic medication.
  4. bNormal weight: Body mass index (BMI) <24.9 kg/m2; overweight: 25 ≤ BMI < 29.9 kg/m2; obese: BMI ≥30 kg/m2.
  5. cHeterogeneity by sex cannot be assessed because the lack of cases in the reference category for women prevents fitting a regression model.