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Table 1 Validity of remission by approximation in major depression

From: Clinical validity of a population database definition of remission in patients with major depression

Validation Method Reference Criteria
Remission by Approximation Clinical Histories
N = 133 Positive Negative
Positive 74 5
Negative 6 48
Statistics Value (%) 95% CI
Validity of the measurement   
   Sensitivity 92.5 88.0 - 96.9
   Specificity 90.6 85.6 - 95.6
   Positive predictive value 93.7 89.6 - 97.8
   Negative predictive value 88.9 83.6 - 94.2
   False positives 7.5 3.0 - 11.9
   False negatives 9.4 4.4 - 14.4
Reliability   
   Cronbach's alpha 90.6 85.6 - 95.6
   Area under the curve 91.2 86.5 - 96.1
Concordance   
   McNemar test 58.1 49.7 - 66.5
   Pearson correlation 82.8 73.1 - 92.5
   Weighted kappa (Cohen) 82.8 73.1 - 92.6
Clinical utility   
   Positive Probability Ratio 9.8 ---
   Negative Probability Ratio 0.1 ---
  1. Reference criteria: Review of patients' histories. Significance: p < 0.001 in all cases. CI: confidence intervals
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