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Table 1 Clinical and management characteristics of the study patients and analysis of features associated with an excessively lengthy treatment.

From: Factors associated with excessively lengthy treatment of tuberculosis in the eastern Paris region of France in 2004

Feature Treatment duration Statistical analyses
  All patients
N = 478
According to
guidelines
N = 316
Excessive
duration
N = 162
Univariate
analysis
Multivariate
analysis
    Number of
patients
Median duration
[IQR]
Odds Ratio
[95%CI]
P value Odds Ratio
[95%CI]
P value
Clinical characteristics         
Previous TB 53 (11.1%) 22 (7.0%) 31 (19.1%) 315 [252-387] 3.0 [1.8-5.8] <0.0001 2.9 [1.6-5.4] 0.001
Isolated thoracic TB 279 (58.4%) 172 (54.4%) 107 (66.0%) 275 [250-311] 1.6 [1.1-2.4] 0.02 2.2 [1.4-3.5] <0.0001
HIV seropositivity 74 (16.9%) 36 (11.4%) 38 (23.5%) 361 [289-418] 2.3 [1.4-3.8] 0.001 2.5 [1.4-4.4] 0.002
Alcoholism 83 (19.4%) 42 (13.3%) 41 (25.3%) 287 [266-367] 2.0 [1.2-3.3] 0.004*** - -
Injecting drug use 10 (2.1%) 02 (0.6%) 08 (4.9%) 352 [305-419] 7.5 [1.6-35.8] 0.01*** - -
Psychiatric disorders 38 (7.9%) 23 (7.3%) 15 (9.3%) 321 [274-367] 1.2 [0.6-2.3] 0.62   
Precarious situation* 210 (43.9%) 137 (43.4%) 73 (45.1%) 292 [274-407] 1.0 [0.7-1.5] 0.98   
Isoniazid resistance 27 (5.6%) 17 (5.4%) 10 (6.2%) 273 [241-396] 1.1[0.5-2.6] 0.72   
Management modalities         
Prescriber      0.002    0.01
   Chest specialist 211 (44.1) 157 (49.7%) 54 (33.3%) 274 [265-315] 1 (reference)   1 (reference)  
   Infectious disease specialist 171 (35.8%) 98 (31.0%) 73 (45.1%) 354 [274-427] 2.2 [1.4-3.3]   2.1 [1.3-3.4]  
   Other 96 (20.1%) 61 (19.3%) 35 (21.6%) 379 [287-498] 1.7 [1.0-2.8]   1.9 [1.1-3.3]  
Number of institutions per patient       0.01   0.001
   1 295 (61.7%) 210 (66.7%) 85 (52.8%) 282 [257-375] 1 (reference)   1 (reference)  
   2 152 (31.8%) 93 (29.5%) 59 (36.6%) 366 [274-448] 1.6 [1.0-2.4]   1.7 [1.1-2.7]  
   ≥3 29 (6.5%) 12 (3.8%) 17 (10.6%) 356 [292-471] 3.5 [1.6-7.6]   4.3 [1.9-10.1]  
Place of follow-up**       0.07***   -
   University hospital 423 (88.5%) 274 (86.7%) 149 (92.0%) 332 [271-431] 1 (reference)    
   Welfare centers or other 55 (11.5%) 42 (13.3%) 13 (8.0%) 276 [273-288] 1.7 [0.9-3.4]    
Directly Observed Therapy 32 (6.7%) 16 (5.1%) 16 (9.9%) 292 [275-352] 2.0 [1.0-4.2] 0.06*** - -
Computerized follow-up 145 (30.3%) 104 (34.2%) 41 (25.3%) 294 [274-367] 0.7 [0.4-1.0] 0.08*** - -
  1. *Poor living conditions and/or no health insurance
  2. **Main structure used by each patient
  3. ***Non significant variables in the multivariate analysis