Skip to main content

Advertisement

Table 6 Results of the sensitivity analyses

From: Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain

  Number of events avoided RVGE costs avoided (M€)
  RVGE cases (seeking or nor medical care) Hospitali-zations Nosocomial infections Emergency visits PCC visits Work Days Lost NHS perspec-tive Societal perspec-tive
BASE CASE 136,190 10,987 2,053 34,287 35,187 161,495 21.77 38.19
SENSITIVITY ANALYSES         
Vaccine coverage rate         
50% 75,670 6,104 1,141 19,049 19,548 89,719 12.09 21.20
97% 146,800 11,841 2,213 36,954 37,924 174,055 23.47 41.16
Ratio not seeking medical care/seeking medical care         
-20% 125,468 10,987 2,053 34,287 35,187 158,836 21.77 37.95
+20% 146,945 10,987 2,053 34,287 35,187 164,415 21.77 38.43
Cost and benefit discount rates         
0%; 0% 136,207 10,987 2,053 34,287 35,187 169,052 22.84 40.02
6%; 6% 136,207 10,987 2,053 34,287 35,187 154,371 20.77 36.46
Incidences         
PCC         
-20% 124,197 10,987 2,053 34,287 28,150 151,082 21.66 36.96
+20% 148,216 10,987 2,053 34,287 42,225 171,908 21.88 39.41
Hospitalization         
-20% 132,534 8,789 2,053 34,287 35,187 154,633 19.17 34.92
+20% 139,880 13,184 2,053 34,287 35,187 168,357 24.37 41.45
Emergency visits         
-20% 125,058 10,987 2,053 27,430 35,187 147,119 20.43 35.40
+20% 147,355 10,987 2,053 41,145 35,187 175,870 23.12 40.98
Nosocomial infections         
-20% 135,796 10,987 1,642 34,287 35,187 160,846 21.48 37.83
+20% 136,617 10,987 2,464 34,287 35,187 162,143 22.07 38.55
Vaccine efficacy in reduction of RVGE cases (95% CI)         
90.5%: hospitalizations, NI 88.8%: emergency visits 73.9%: PCC and home care 121,187 10,379 1,939 32,494 30,236 147,707 20.54 35.54
98.2%: hospitalizations, NI 96.5%: emergency visits 92.5%: PCC and home care 144,258 11,262 2,104 35,312 37,847 168,854 22.39 39.55
Vaccine efficacy annual rate by age         
10% decrease in year 2 and exponential decrease until year 4. 135.507 10,891 2,051 34,208 34,987 160,770 21.65 37.99
NHS & Societal costs (95% CI)         
Lower values 136,1901 10,987 2,053 34,287 35,187 161,4951 19.59 33.57
Higher values 36,190 10,987 2,053 34,287 35,187 61,495 23.94 44.64