Table 6 Results of the sensitivity analyses

BASE CASE

136,190

10,987

2,053

34,287

35,187

161,495

21.77

38.19

SENSITIVITY ANALYSES

Vaccine coverage rate

50%

75,670

6,104

1,141

19,049

19,548

89,719

12.09

21.20

97%

146,800

11,841

2,213

36,954

37,924

174,055

23.47

41.16

Ratio not seeking medical care/seeking medical care

-20%

125,468

10,987

2,053

34,287

35,187

158,836

21.77

37.95

+20%

146,945

10,987

2,053

34,287

35,187

164,415

21.77

38.43

Cost and benefit discount rates

0%; 0%

136,207

10,987

2,053

34,287

35,187

169,052

22.84

40.02

6%; 6%

136,207

10,987

2,053

34,287

35,187

154,371

20.77

36.46

Incidences

PCC

-20%

124,197

10,987

2,053

34,287

28,150

151,082

21.66

36.96

+20%

148,216

10,987

2,053

34,287

42,225

171,908

21.88

39.41

Hospitalization

-20%

132,534

8,789

2,053

34,287

35,187

154,633

19.17

34.92

+20%

139,880

13,184

2,053

34,287

35,187

168,357

24.37

41.45

Emergency visits

-20%

125,058

10,987

2,053

27,430

35,187

147,119

20.43

35.40

+20%

147,355

10,987

2,053

41,145

35,187

175,870

23.12

40.98

Nosocomial infections

-20%

135,796

10,987

1,642

34,287

35,187

160,846

21.48

37.83

+20%

136,617

10,987

2,464

34,287

35,187

162,143

22.07

38.55

Vaccine efficacy in reduction of RVGE cases (95% CI)

90.5%: hospitalizations, NI

88.8%: emergency visits

73.9%: PCC and home care

121,187

10,379

1,939

32,494

30,236

147,707

20.54

35.54

98.2%: hospitalizations, NI

96.5%: emergency visits

92.5%: PCC and home care

144,258

11,262

2,104

35,312

37,847

168,854

22.39

39.55

Vaccine efficacy annual rate by age

10% decrease in year 2 and exponential decrease until year 4.

135.507

10,891

2,051

34,208

34,987

160,770

21.65

37.99

NHS & Societal costs (95% CI)

Lower values

136,1901

10,987

2,053

34,287

35,187

161,4951

19.59

33.57

Higher values

36,190

10,987

2,053

34,287

35,187

61,495

23.94

44.64