From: Psychotropic drugs and the risk of fractures in old age: a prospective population-based study
Drug | Number of fracture cases No. (%)/controls No. (%) | Univariate analysis | Age-adjusted analysis | Adjusted analysisa | |||
---|---|---|---|---|---|---|---|
 |  | RR (95% CI) | P-value | RR (95% CI) | PValue | RR (95% CI) | P-value |
3-year follow-up | |||||||
One BZD | 22 (11.8)/46 (11.9) | 1.0 (0.6-1.7) | .88 | 0.9 (0.5-1.5) | .66 | - | - |
One AP | 9 (14.1)/46 (11.9) | 1.3 (0.6-2.7) | .47 | 1.1 (0.5-2.2) | .83 | - | - |
One AD | 3 (7.9)/46 (11.9) | 0.7 (0.2-2.2) | .52 | 0.6 (0.2-1.9) | .36 | - | - |
Two or more BZDs | 6 (16.2)/46 (11.9) | 1.4 (0.6-3.4) | .40 | 1.3 (0.5-3.0) | .60 | - | - |
Two or more APs | 3 (33.3)/46 (11.9) | 3.8 (1.2-12.2) | .03 | 3.3 (1.0-10.7) | .05 | 1.0 (0.1-7.0) | .98 |
Two or more ADs | 0 (0.0)/46 (11.9) | - | - | - | - | - | - |
BZD and APb | 5 (17.2)/46 (11.9) | 1.7 (0.7-4.4) | .24 | 1.4 (0.6-3.6) | .46 | - | - |
BZD and ADb | 2 (8.0)/46 (11.9) | 0.7 (0.2-2.9) | .62 | 0.6 (0.1-2.5) | .47 | - | - |
AP and ADb | 2 (15.4)/46 (11.9) | 1.4 (0.3-5.7) | .65 | 1.1 (0.3-4.7) | .86 | - | - |
6-year follow-up | |||||||
One BZD | 33 (17.7)/76 (19.6) | 1.0 (0.6-1.5) | .89 | 0.8 (0.6-1.3) | .43 | - | - |
One AP | 13 (20.3)/76 (19.6) | 1.2 (0.7-2.2) | .54 | 1.0 (0.6-1.8) | .98 | - | - |
One AD | 5 (13.2)/76 (19.6) | 0.7 (0.3-1.8) | .48 | 0.6 (0.2-1.5) | .30 | - | - |
Two or more BZDs | 7 (18.9)/76 (19.6) | 1.0 (0.5-2.2) | .95 | 0.9 (0.4-2.0) | .81 | - | - |
Two or more APs | 3 (33.3)/76 (19.6) | 2.9 (0.9-9.2) | .07 | 2.6 (0.8-8.3) | .10 | - | - |
Two or more ADs | 0 (0.0)/76 (19.6) | - | - | - | - | - | - |
BZD and APb | 7 (24.1)/76 (19.6) | 1.6 (0.8-3.6) | .21 | 1.4 (0.6-3.0) | .43 | - | - |
BZD and ADb | 3 (12.0)/76 (19.6) | 0.7 (0.2-2.1) | .48 | 0.6 (0.2-1.8) | .34 | - | - |
AP and ADb | 4 (30.8)/76 (19.6) | 1.9 (0.7-5.2) | .21 | 1.6 (0.6-4.4) | .38 | - | - |