Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies

Table 1 Summary of identified randomised controlled trials

Study first author (country) year	Study population	Mean age (years)	Vitamin D				Control		Hip Fractures	RR/HR
			n	Eqv daily dose and type	Mode of admin	25(OH)D Baseline nmol/L	n	25(OH)D Baseline nmol/L	Number Vit D/ Control
Vitamin D vs. Placebo/No treatment trials
Lips [29] (Netherlands) 1996	Community & limited care residents	80	1291	400 IU	oral	27	1287	26	58/48	HR
				D₃						1.18 (0.81-1.71)
Meyer [30] (Norway) 2002	Nursing home residents	84.7	569	400 IU	oral	47	575	51	50/47	HR
				D₃						1.09 (0.73-1.63)
Trivedi [31] (UK) 2003	Community Doctors' and GP registry	74.8	1345	822 IU	oral	NA	1341	53.4	21/24	HR
				D₃						0.85 (0.47-1.53)
Grant [21] (UK) 2005	Community residents with previous fracture	77	1343	800 IU	oral	38.0	1332	38.0	47/41	RR
				D₃						1.14 (0.75-1.72)
Law [32] (UK) 2006	Residential care and nursing home residents	85	1762	1100 IU	oral	59	1955	NA	24/20	RR
				D₂						1.36 (0.80-2.34)
Lyons [22] (UK) 2007	Residential, nursing homes and sheltered housing residents	84	1725	822 IU	oral	NA	1715	NA	112/104	RR
				D₂						1.07 (0.83-1.39)
Smith [33] (UK) 2007	Community residents	79.1	4727	822 IU	Intra-musc. (IM)	141.25	4713	141.25	66/44	HR
				D₂						1.49 (1.02-2.18)
Vitamin D and Calcium vs. Calcium trials
Grant [21] (UK) 2005	Community residents with previous fracture	77	1306	800 IU D₃ + 1000 mg Calcium(daily)	oral	38.0	1311	38.0	46/49	RR
										0.94 (0.63-1.40)

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