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Table 1 Summary of identified randomised controlled trials

From: Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies

Study first author (country) year Study population Mean age (years) Vitamin D Control Hip Fractures RR/HR
    n Eqv daily dose and type Mode of admin 25(OH)D Baseline nmol/L n 25(OH)D Baseline nmol/L Number
Vit D/ Control
 
Vitamin D vs. Placebo/No treatment trials
Lips [29] (Netherlands) 1996 Community & limited care residents 80 1291 400 IU oral 27 1287 26 58/48 HR
     D3       1.18 (0.81-1.71)
Meyer [30] (Norway) 2002 Nursing home residents 84.7 569 400 IU oral 47 575 51 50/47 HR
     D3       1.09 (0.73-1.63)
Trivedi [31] (UK) 2003 Community Doctors' and GP registry 74.8 1345 822 IU oral NA 1341 53.4 21/24 HR
     D3       0.85 (0.47-1.53)
Grant [21] (UK) 2005 Community residents with previous fracture 77 1343 800 IU oral 38.0 1332 38.0 47/41 RR
     D3       1.14 (0.75-1.72)
Law [32] (UK) 2006 Residential care and nursing home residents 85 1762 1100 IU oral 59 1955 NA 24/20 RR
     D2       1.36 (0.80-2.34)
Lyons [22] (UK) 2007 Residential, nursing homes and sheltered housing residents 84 1725 822 IU oral NA 1715 NA 112/104 RR
     D2       1.07 (0.83-1.39)
Smith [33] (UK) 2007 Community residents 79.1 4727 822 IU Intra-musc. (IM) 141.25 4713 141.25 66/44 HR
     D2       1.49 (1.02-2.18)
Vitamin D and Calcium vs. Calcium trials
Grant [21] (UK) 2005 Community residents with previous fracture 77 1306 800 IU D3 + 1000 mg Calcium(daily) oral 38.0 1311 38.0 46/49 RR
           0.94 (0.63-1.40)
  1. Eqv Equivalent
  2. RR Relative risk
  3. HR Hazard Ratio
  4. IU International Units