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Table 1 Study Design for Eight Youth HIV Prevention Interventions in Systematic Review

From: HIV prevention for South African youth: which interventions work? A systematic review of current evidence

Project Description Objective Target Population/Age Experimental Design & Sample Size Control or Comparison Condition Duration of Follow-up
HAPS [32]
[HIV/AIDS Prevention Study] KwaZulu/Natal
Reduce sexual and alcohol risk-taking behaviors Secondary School students, Grade 9; Ages: 14-16 years Random assignment at school level; 3 intervention, 2 comparison schools
N = 325 I; N = 336 C; pre-post survey
Standard life skills/life orientation curriculum Follow up survey: 2 months post-intervention
HealthWise [34]
Reduce STI/HIV transmission, drug/alcohol abuse and increase positive use of leisure time Secondary school students, Grades 8-9
Ages 12-14 in urban township setting;
Pre-and post-intervention surveys; in 3 8th grade cohorts;
4 intervention, 5 control schools randomly assigned;
N = 901 I; N = 1275 C
Standard life skills/life orientation curriculum 5 waves of data collection for each cohort over 1.5 years
Mpondombili Project [33] KwaZulu/Natal Promote safer sex behaviors, with emphasis on dual protection, sexual risk-reduction, and promotion of positive gender role norms Secondary School students: Grades 8-10 in rural secondary schools Baseline and follow up surveys in 2 intervention and 2 comparison schools, not randomized; N = 442 I; N = 541C Standard life skills/life orientation curriculum; comparison schools received shortened version of curriculum (delayed) Follow up survey: 5 months post-intervention
Adolescent Livelihoods[35]
Reduce HIV risks and social vulnerabilities, increase access to 'safe spaces' and life skills Urban township; Out of school youth aged 16-24; in-school youth aged 14-20 Quasi-experimental; group assignment   2 years
SATZ [31, 37, 51, 52]
CapeTown and Northern Province
To develop, implement and evaluate a school-based health education program aimed at promotion of correct, consistent condom use and delay in sexual debut School students in urban township and rural area; ages 12-14 in grade 8 1 pre- and 2 post-test assessments within quasi-experimental design; 13 intervention and 13 control schools; not randomized. N = 3625 Comparison schools received delayed intervention 1 year
Stepping Stones[11, 38]
Eastern Cape
Promote sexual and reproductive health via HIV prevention and reduction in sexual coercion and intimate partner violence Semi-urban township; older adolescents and young adults aged 18-24; in- and out-of-school youth Cluster RCT; matched control group; 35 I clusters; 35 C clusters. Sample size: 2770 N = 1140 I; N = 1081C Single session on HIV, condoms, safe sexual behaviors 2 years post-intervention with 2 assessments, at 12 months and 24 months
Tshwane Peer Education and Support Programme[36]
Tshwane (Pretoria), Gauteng
Promote accurate information about HIV/AIDS, address peer norms, establish psychosocial support High school students ages 13-20, in semi-rural secondary schools 13 intervention and 4 control schools; not randomized. Pre-post survey of one selected class in each school.
N = 1572 I; N = 596 C
Ongoing Life Orientation or other HIV prevention activities 18 months
IMAGE - Intervention with Microfinance for AIDS and Gender Equity[12, 13] To evaluate effects of combined microfinance and training intervention on HIV risk behavior Of 3 evaluation cohorts, one cohort of 14-35 year old women Cluster RCT; 8 pair-matched villages. N = 130(I); N = 132 (C) Villages randomised to control received standard of care; available sexual health info; no microfinance 2 years