Table 1 The comparisons of time series components between the series of mild and severe HFMD cases

 Biennial increase (%)

124.46 (122.80, 126.14)

91.20 (89.69, 92.74)

1.36 (1.34,1.39)

<0.001

 peak value

1.04 (1.00,1.07)

0.87 (0.82,0.93)

1.19 (1.11,1.27)

<0.001

 peak time (days)

134.7 (133.77,135.68)

131.48 (129.83,133.13)

3.21 (1.42,5.08)

<0.001

 peak value

0.24 (0.20,0.27)

0.21 (0.16,0.26)

1.14 (0.88,1.52)

0.081

 peak time (days)

97.47 (91.34,103.51)

74.78 (64.86,83.81)

22.69 (11.03,34.24)

0.001

 peak value

1.78 (1.73,1.83)

3.08 (2.97,3.19)

0.58 (0.55,0.60)

<0.001

 peak time (days)

183.08 (181.79,184,48)

176.52 (175.27,177.77)

6.56 (4.89,8.52)

<0.001

 peak value

0.40 (0.36,0.43)

0.80 (0.75,0.86)

0.49 (0.44,0.56)

<0.001

 peak time (days)

466.49 (456.14,477.35)

492.55 (483.99,502.11)

−26.06 (−40.96,−11.92)

<0.001

 Start time (days)

36 (35,38)

27 (25,29)

9 (7,11)

<0.001

 Major peak time (days)

155 (153,156)

156 (155,158)

−1 (−3,0)

0.012

 Major peak value

1.23 (1.19,1.28)

2.10 (2.00,2.19)

0.59 (0.56,0.62)

<0.001

 Minor peak time (days)

288 (284,292)

-

-

-

 Minor peak value

0.44 (0.42,0.47)

-

-

-

 Start time (days)

391 (390,392)

377 (375,379)

14 (11,16)

<0.001

 Major peak time (days)

510 (509,511)

513 (512,514)

−3 (−4,−1)

<0.001

 Major peak value

1.90 (1.85,1.96)

4.20 (4.07,4.34)

0.45 (0.43,0.47)

<0.001

 Minor peak time (days)

661 (659,664)

-

-

-

 Minor peak value

0.42 (0.36,0.44)

-

-

-