Euthanasia and other end-of-life decisions: a mortality follow-back study in Belgium
© Block et al; licensee BioMed Central Ltd. 2009
Received: 25 September 2008
Accepted: 09 March 2009
Published: 09 March 2009
This study compares prevalence and types of medical end-of-life decisions between the Dutch-speaking and French-speaking communities of Belgium. This is the first nationwide study that can make these comparisons and the first measurement after implementation of the euthanasia law (2002).
We performed a mortality follow-back study in 2005–2006. Data were collected via the nationwide Sentinel Network of General Practitioners, an epidemiological surveillance system representative of all Belgian GPs.
Weekly, all GPs reported the medical end-of-life decisions among all non-sudden deaths of patients in their practice. We compared the northern Dutch-speaking (60%) and southern French-speaking communities (40%) controlling for population differences.
We analysed 1690 non-sudden deaths. An end-of-life decision with possible life-shortening effect was made in 50% of patients in the Dutch-speaking community and 41% of patients in the French-speaking community (OR 1.4; 95%CI, 1.2 to 1.8). Continuous deep sedation until death occurred in 8% and 15% respectively (OR 0.5; 95%CI, 0.4 to 0.7). Community differences regarding the prevalence of euthanasia or physician-assisted suicide were not significant.
Community differences were more present among home/care home than among hospital deaths: non-treatment decisions with explicit life-shortening intention were made more often in the Dutch-speaking than in the French-speaking community settings (OR 2.2; 95%CI, 1.2 to 3.9); while continuous deep sedation occurred less often in the Dutch-speaking community settings (OR 0.5; 95%CI, 0.3 to 0.9).
Even though legal and general healthcare systems are the same for the whole country, there are considerable variations between the communities in type and prevalence of certain end-of-life decisions, even after controlling for population differences.
Several studies have shown that death is often preceded by a medical end-of-life decision with possible or certain life-shortening effect such as non-treatment decisions, intensification of symptom alleviation, euthanasia, physician-assisted suicide, or the use of lethal drugs without the patient's explicit request [1–20]. Both the incidence and the characteristics of the decision-making process have been found to differ between countries [4, 7, 14, 16, 20, 21]. However, even when using the same methodology in international comparative research, interpretation of differences between countries is very difficult since totally different legal and healthcare systems need to be compared.
Belgium is a unique country in which to study variations in end-of-life decision-making. It is one country, where legal and general healthcare structures (e.g. social security system, accessibility criteria for healthcare provision, general healthcare budget) are defined and regulated at national level, but where two language communities can be differentiated: the Dutch-speaking northern community (60% of the population) and the French-speaking southern community (40%), both separately responsible for policy concerning culture, education, and certain aspects of healthcare (e.g. prevention, organisation of healthcare) [22–26]. The investigation of whether variations in end-of-life decisions occur under these circumstances can give important insights into the factors underlying them.
Furthermore, Belgium is one of the three countries in the world with a law on euthanasia . Notification of euthanasia cases is legally obligatory. However, despite having the same legal system, it is remarkable that 82% of all cases reported to the Federal Evaluation and Control Committee on Euthanasia in 2005 and 2006 came from Dutch-speaking physicians, while only 18% came from French-speaking physicians [27–29]. The largest proportional difference was found for patients who died at home or in care homes (92%-8%) compared to hospital settings (81%-19%) . Because this cannot be explained by differences in population size, finding empirically-supported explanations has become an issue of considerable medical and societal debate. It also raises questions concerning differences in other end-of-life decisions in homecare and hospital settings.
Previous reports concerning end-of-life decision-making in Belgium could not make comparisons between the two communities. Due to the absence of recent death certificates in the French-speaking community which would identify physicians, previous reports only cover the Dutch-speaking community [3, 4]. Additionally, these figures date from the time before the euthanasia law was implemented in 2002 [3, 4, 22].
The objective of this study is to investigate possible differences in prevalence and types of end-of-life decisions between the Dutch-speaking and French-speaking communities of Belgium after the implementation of the euthanasia law. We focus on three research questions. How prevalent are different types of end-of-life decisions in Belgium in 2005–2006? Are there differences between the two communities in the prevalence of different types of end-of-life decisions or in the decision-making process? Are these differences present in homecare settings as well as in hospital settings in both communities?
Because general practitioners (GPs) are pivotal healthcare providers in Belgium and 95% of the population, including care home residents, have a regular GP , we collaborated with the existing nationwide Belgian Sentinel Network of General Practitioners to study a population-based sample of deaths in Belgium. This network, operational since 1979, has proved to be a reliable surveillance system for a wide variety of health-related epidemiological data [31–33]. In 2005 and 2006, it consisted of respectively 181 and 174 regularly participating practices, representative of all 10,578 GPs in Belgium in terms of age, gender and region and covering 1.75% of the total Belgian patient population [31, 34].
In 2005 and 2006, this network participated in a two-year nationwide mortality follow-back study, the senti-melc study, which was designed to monitor end-of-life care via this sentinel GP Network . The GPs from the sentinel network registered weekly all deaths of patients in their practice older than one year, including deaths that occurred in hospital settings. They registered each death immediately it occurred or immediately on being informed, using a standardised form. If patients died in a hospital setting, GPs were informed by the hospital specialists.
Anonymity of the patient and the physician was preserved. Every patient that is registered within the network received an anonymous reference from the GP him/herself, and all identification codes of the GPs were replaced in the data files with anonymous codes during data cleaning. Details of this procedure are described elsewhere . The study protocol was approved by the Ethical Review Board of Brussels University Hospital.
The first part of the registration surveyed the patient characteristics of all registered patients and whether or not death had occurred "suddenly and totally unexpectedly" [4, 35]. For patients who died non-suddenly, a second part surveyed end-of-life decision-making. Following previous studies [3, 4] we studied 4 types of end-of-life decisions with a possible or certain life-shortening effect, taken by the responding GP him/herself or by another physician: (1) non-treatment decisions (taking into account a possible hastening of death or with the explicit intent to hasten death); (2) intensifying alleviation of pain or other symptoms (taking into account or co-intending the hastening of death); (3) administering (i.e. euthanasia), supplying or prescribing (i.e. physician-assisted suicide) drugs with the explicit intention of hastening death on the patients' explicit request; and (4) administering drugs with the explicit intention of hastening death without explicit patient request. Concerning the decision-making process, we investigated whether the decision was taken after discussion with the patient, on his/her explicit request, and whether the patient was competent to make decisions. The GPs were instructed to fill in these questions only if one of the questions on end-of-life decisions was answered "yes".
Finally, we also asked whether or not continuous deep sedation was performed, defined as a patient being deeply and continuously sedated or in a coma until death, by means of e.g. benzodiazepines or barbiturates (continuous deep sedation) and if so, whether artificial food or fluid was administered (palliative sedation) or not (terminal sedation). The wording of all questions and classification of practices was identical to previous incidence studies although these used another research design [1–4, 10, 17].
The instrument was first developed in Dutch and then translated into French via forward-backward translation. It was tested and slightly adapted after an extensive pilot study . Several control measures were used to ensure data quality: automatic follow-up and possible telephone contact with the GP to prevent missing data for key variables (e.g. euthanasia), data-entry with consistency, range and skip checks, and double data-entry.
We calculated the prevalence of end-of-life decisions for Belgium using binominal 95% confidence intervals (exact method). To analyse differences between the communities in Belgium, we compared cases from physicians in the Dutch-speaking northern part with cases from physicians in the French-speaking southern part. We used logistic regression analysis to calculate odds-ratios correcting for differences in patient characteristics. Interaction effects between community and each patient characteristic were systematically evaluated. We studied differences between the communities in total, as well as for homecare and hospital settings separately subdivided on the basis of the patient's place of death. Differences in decision-making characteristics were studied using Fishers' Exact Tests. All analyses were performed using StatXact6 (Cytel Studio, Cambridge, MA) and SPSS14.0 (SPPS Inc, Chicago, IL).
Characteristics of the study population of non-sudden deaths by community in Belgium
N = 1032
N = 658
Total for Belgium
N = 1690
Elementary or lower
Cause of deathb
Dis. nervous systemc
Place of death
Home or with family
Palliative care unit
Frequencies of end-of-life practices
Frequency of end-of-life decisions in non-sudden deaths in Belgium, according to community
Most important end-of life decision that possibly hastened death (ELD)
Number of deaths studied a
Administering life-ending drugs without explicit patient request
Intensified alleviation of symptoms
Withholding or withdrawing of life-prolonging treatment
Total ELD with partly or explicitly life-shortening intent
Continuous deep sedation f
Number of deaths studied a
forgoing artificial food/fluid
Controlling for differences in patient age, sex, educational level, cause of death and place of death, the chance of dying following a possibly life-shortening end-of-life decision was higher in the Dutch- (50%) than in the French-speaking community (41%) of Belgium (OR 1.4; 95% CI, 1.2 to 1.8) (Table 2). Selecting all end-of-life decisions with a partly or explicitly life-shortening intention, this difference remained significant (OR 1.4; 95% CI, 1.1 to 1.9). We found higher frequencies for all types of end-of-life decisions with possible life-shortening effect in the Dutch- than in the French-speaking community, but differences did not reach significance at a 95% confidence interval level for any specific type. Euthanasia or physician-assisted suicide (PAS) was performed in 1.6% and 0.9% of cases in the Dutch- and French-speaking community respectively (OR non-significant). Continuous deep sedation both while administering and forgoing food/fluid was registered less often in the Dutch- (8%) than in the French-speaking community (15%) (OR 0.5; 95% CI, 0.4 to 0.7).
Frequency of end-of-life decisions in non-sudden deaths according to community and setting in Belgium
Place of death
Home or care home
Hospital or palliative care unit
Administering life-ending drugs without explicit patient request
Intensified alleviation of symptoms taking life-shortening into account
Intensified alleviation of symptoms with partly life-shortening intent
2.47 [1.06–5.75] b
Non-treatment taking life-shortening into account
Non-treatment with explicit life-shortening intent
Continuous deep sedation forgoing food/fluid
0.58 [0.33–1.02] b
Continuous deep sedation administrating food/fluid
In the hospital, community differences for end-of-life decisions with possible life-shortening effect were never statistically significant. Continuous deep sedation did occur significantly less frequently in the Dutch- than in the French-speaking community, especially while administering food and fluid (8% versus 18%).
Discussion with patient
Discussion with patient of end-of-life decisions in Belgium, according to community
Total for Belgium
Number of deaths studied a
Discussion with patient b
Administering life-ending drugs without explicit patient request
Intensified alleviation of symptoms
Withholding or withdrawing of life-prolonging treatment
End-of-life decisions with possible, partly or explicitly life-shortening intent occurred in approximately half of all non-sudden deaths in Belgium. Intensified alleviation of symptoms and non-treatment decisions were most prevalent, while euthanasia or physician-assisted suicide (PAS) occurred in 1.3% of cases and life-ending drugs use without explicit patient request in 1.6% of cases. Continuous deep sedation until death occurred in one in ten non-sudden deaths. Although comparing with other studies is difficult due to other research designs, in general, the relatively high occurrence of symptom alleviation, sedation and non-treatment decisions, especially compared to the use of lethal drugs, was also found in previous studies in Belgium, and in several other European countries [3, 4, 10]. Life-ending drug use without explicit patient request was also found to be relatively high in previous studies in the Dutch-speaking community of Belgium compared to other countries in the world [3, 4]. However, we found some remarkable differences between the Dutch- and French-speaking communities in type and prevalence of certain end-of-life decisions, even after controlling for population differences. End-of-life decisions with possible life-shortening effect in general were more prevalent in the Dutch-speaking community, while the practice of continuous deep sedation was more prevalent in the French-speaking community. We could observe a tendency towards higher frequencies of euthanasia/PAS in the Dutch-speaking community, but differences were not significant. Variations between communities did occur according to care setting especially for non-treatment decisions and continuous deep sedation. There were no significant variations in the extent to which decisions were discussed with the patients.
This is the first study on end-of-life decisions in Belgium covering the whole country and the first to describe variations between two language communities in a country where euthanasia is legal. Important strengths of the study include the use of a nationwide and representative surveillance network with a long history of registration research, not selected on the basis of a specific interest in end-of-life research [31, 34]; the representativeness of the identified sample of non-sudden deaths; and the quality of the research procedures e.g. weekly registrations could limit memory bias [4, 39]. The percentage of non-sudden deaths was also comparable to previous death certificate studies .
This study also has limitations. Firstly, GPs were asked to retrospectively indicate whether they or another physician had taken an end-of-life decision. Underestimation is possible especially for patients dying in a hospital and in particular for specific types of decisions which can be seen as part of routine clinical practice and are thus generally less often discussed with other professionals e.g. intensified symptom alleviation [3, 18, 19]. Results also confirmed that missing data were highest for hospital deaths and for the decision-making process of symptom alleviation. However, it should be noted that a possible underestimation of certain types of decision-making does not make the intra-country comparisons less valid. It does make comparisons with previous incidence studies in Flanders using another research design [3, 4] less feasible, especially for these hospital deaths. Secondly, a possible selection or recall bias due to the retrospective design cannot be excluded. Thirdly, due to a low number of cases for some decisions e.g. euthanasia, small differences between groups might not have been identified. Fourthly, the high percentage of missing data concerning the end-of-life decision-making process – probably due to the difficult instructions used – might have biased these results. Fifthly, we did not measure differences in the patient's symptom severity nor in the attitudes of physicians which might have further explained the variations found. We could only control for community differences in patients' age, sex, educational level, cause of death, place of death and possible interaction effects while other possible confounders were not measured. Finally, language was used to differentiate between the two communities of Belgium, but cannot be used to explain the differences we found. Even though language and culture are strongly related, the study of specific underlying cultural factors could have explained the results more fully.
Even though Belgium is a country with one legal and general healthcare system, the higher prevalence of possibly life-shortening end-of-life decisions and lower prevalence of continuous deep sedation in the Dutch-speaking community compared with the French-speaking is remarkable. The difference remained present even after controlling for possible variation in patient characteristics such as age, sex, cause and place of death. Continuous deep sedation is a specialist technique used to relieve intolerable suffering and control refractory distressful symptoms in the last phase of life . Contrary to the other end-of-life decisions where a possible life-shortening effect is always taken into account and sometimes explicitly intended, a life-shortening effect is generally not intended nor expected in cases of continuous deep sedation, except if artificial food and fluid are forgone (i.e. terminal sedation). In these latter cases, death generally is expected and in some cases also intended [14, 40, 41]. Hence, in the Dutch-speaking community, physicians, patient or their families seem to be more readily prepared to make or ask for life-shortening decisions than in the French-speaking community. In the French-speaking community, they seem to prefer to prolong life for longer, continuing available treatments (including the use of sedative drugs) and to intervene later in the dying process using less direct ways.
This finding corresponds to previous reports on end-of-life care in Belgium. Compared to patients in the Dutch-speaking community, patients in the French-speaking community more often receive possibly life-prolonging treatments and treatment goals are aimed at cure or prolonging life for a longer time in the final three months of life . Additionally, studies from other domains have shown a higher consumption of technological specialist care in the French-speaking part . This stronger appreciation of curative, technological and specialist medicine in the French-speaking community might explain the rarer use of life-shortening decisions and preference towards specialist techniques such as continuous deep sedation. This might be rooted in a general difference in medical culture between the two communities. Since other cross-country studies have shown that life-prolonging treatments (e.g. CPR) and sedative techniques are used more often in southern European countries while possibly life-shortening decisions are more prevalent in several northern European countries [4, 14, 20, 21, 26, 42, 43], the French-speaking community of Belgium seems more closely related to the Latin-French culture in southern European countries, while the Dutch-speaking community corresponds more closely to the northern Germanic European countries.
Therefore, the fact that the public debate on life-shortening and the regulation of euthanasia started early in the Netherlands  – lying north of Belgium and where the same language is spoken as in the Dutch-speaking part of Belgium – might have had an early influence on the Dutch-speaking community in Belgium, which was probably absent in the French-speaking community, leading to a higher tendency towards life-shortening decision-making .
Concerning euthanasia/PAS, there was a tendency towards a higher prevalence in the Dutch-speaking community but differences were not statistically significant, possibly due to the small number of observed cases. However, actual differences apparently are not large enough to explain the disproportionate percentages observed in the legal notification rate of euthanasia, especially in the home or care home settings [27–29]. Thus, French-speaking physicians, especially general practitioners, seem to report their cases less often to the Federal Evaluation and Control Committee on Euthanasia than the Dutch-speaking. Unfortunately, reasons for this could not be explored. Perhaps French-speaking GPs were less well-informed about the law as the media coverage on euthanasia is higher and training initiatives for physicians are more present in the Dutch-speaking community . Alternatively, culturally determined attitudes towards legal evaluation of medical practices might differ between the two communities. This finding warrants further investigation of French-speaking physicians' attitudes towards the law on euthanasia.
In this study, some interesting setting-specific differences also became apparent. Firstly, analysis showed a higher prevalence of non-treatment decisions with explicit life-shortening effect in the homes/care homes in the Dutch-speaking community but a higher prevalence of continuous deep sedation especially while forgoing artificial food/fluid (terminal sedation) in the French-speaking community, an effect not found in hospitals. Possibly, French-speaking GPs postpone any decision about whether or not a treatment is futile for longer, or let things take their course for a longer time and are then more readily prepared to use sedative drugs instead. Forgoing food/fluid might be a logical consequence of sedative therapy intending to let a patient pass away gently and not a decision primarily intended to shorten life [14, 40]. This might partly be explained by the fact that training and consultation initiatives concerning end-of-life decision-making (e.g. communication guidelines, training of physicians to consult colleague physicians) more often originated in the Dutch-speaking community setting in Belgium . Also, preferences for certain end-of-life practices might have a more profound impact in general practice where physicians need to make decisions on their own, compared with hospitals where physicians work within well-defined structures with specific policies regarding complex medico-ethical decisions such as the futility of treatments. However, these hypotheses need more research before definite conclusions can be drawn.
Secondly, continuous deep sedation while administering food/fluid was found to occur noticeably more in hospital settings in the French-speaking community (18% of all non-sudden deaths). Possibly, feeding or hydrating the patient indicates that the physician wants to keep the patient alive . Therefore, the finding might be explained by the strong orientation towards cure in hospital cultures  fortified by the general preference for technological curative medicine in the southern community [20, 21, 30, 38, 43]. French-speaking hospital physicians seem to reach out for this treatment option sooner or more easily than Dutch-speaking physicians to treat complex problems of terminal patients.
Even within one country with one legal system and the same basic healthcare options and structures, systematic differences in prevalence and legal reporting of medical end-of-life decisions can occur. Societal and cultural differences between both communities possibly play an important role in determining responses to end-of-life suffering. Further anthropological study is needed to shed light on the mechanisms underlying differences in end-of-life decision-making.
The first author received a student grant from the Fund for Scientific Research in Flanders, Belgium. Support for the study came from the Research Council of the Vrije Universiteit Brussel in Belgium (project GOA27 2003–2007) and the Institute for the Promotion of Innovation by Science and Technology in Flanders as a Strategic Basic Research project (SBO) (contract SBO IWT 050158) (2006–2010), as part of the 'Monitoring Quality of End-of-Life Care (MELC) Study'. The Belgian Sentinel Network of GPs is supported by the Flemish and Walloon Ministry of Welfare, Public Health and Family. The sponsors had no role in design and conduct of the study, in the collection, analysis, and interpretation of the data, in the writing of the report or in the decision to submit the article for publication.
The authors would like to thank Katrien Drieskens, MD (Vrije Universiteit Brussel) and Sabien Bauwens, MA (Brussels University Hospital), for their contributions in study conception and support in data collection; Johan Vanoverloop, MA (Vrije Universiteit Brussel), for his statistical advice; Jane Ruthven for English editing, Rita De Boodt (Flemish Ministry of Welfare, Public Health and Family) for categorizing the cause of death into ICD-10 codes in this study; the participating sentinel GPs for providing the study data; and the Flemish Ministry of Welfare, Public Health and Family and the Brussels Observatory of Health and Wellness for giving us access to their death certificate data. None of these persons received any compensation for their roles in the study.
- Maas van der PJ, van Delden JJ, Pijnenborg L, Looman CW: Euthanasia and other medical decisions concerning the end of life. Lancet North Am Ed. 1991, 338: 669-674.Google Scholar
- van der Maas PJ, van der Wal G, Haverkate I, de Graaff CL, Kester JG, Onwuteaka-Philipsen BD, van der Heide A, Bosma JM, Willems DL: Euthanasia, physician-assisted suicide, and other medical practices involving the end of life in the Netherlands, 1990–1995. N Engl J Med. 1996, 335: 1699-1705. 10.1056/NEJM199611283352227.View ArticlePubMedGoogle Scholar
- Deliens L, Mortier F, Bilsen J, Cosyns M, Stichele vander R, Vanoverloop J, Ingels K: End-of-life decisions in medical practice in Flanders, Belgium: a nationwide survey. Lancet. 2000, 356: 1806-1811. 10.1016/S0140-6736(00)03233-5.View ArticlePubMedGoogle Scholar
- van der Heide A, Deliens L, Faisst K, Nilstun T, Norup M, Paci E, van der Wal G, van der Maas PJ: End-of-life decision-making in six European countries: descriptive study. Lancet. 2003, 362: 345-350. 10.1016/S0140-6736(03)14019-6.View ArticlePubMedGoogle Scholar
- Onwuteaka-Philipsen BD, van der Heide A, Koper D, Keij-Deerenberg I, Rietjens JA, Rurup ML, Vrakking AM, Georges JJ, Muller MT, van der Wal G, van der Maas PJ: Euthanasia and other end-of-life decisions in the Netherlands in 1995, and 2001. Lancet. 1990, 362: 395-399. 10.1016/S0140-6736(03)14029-9.View ArticleGoogle Scholar
- Bilsen J, Stichele vander R, Mortier F, Bernheim J, Deliens L: The incidence and characteristics of end-of-life decisions by GPs in Belgium. Fam Pract. 2004, 21: 282-289. 10.1093/fampra/cmh312.View ArticlePubMedGoogle Scholar
- Bosshard G, Nilstun T, Bilsen J, Norup M, Miccinesi G, van Delden JJ, Faisst K, Heide van der A: Forgoing treatment at the end of life in 6 European countries. Arch Intern Med. 2005, 165: 401-407. 10.1001/archinte.165.4.401.View ArticlePubMedGoogle Scholar
- Seale C: Characteristics of end-of-life decisions: survey of UK medical practitioners. Palliat Med. 2006, 20: 653-659. 10.1177/0269216306070764.View ArticlePubMedGoogle Scholar
- Seale C: National survey of end-of-life decisions made by UK medical practitioners. Palliat Med. 2006, 20: 3-10. 10.1191/0269216306pm1094oa.View ArticlePubMedGoogle Scholar
- van der Heide A, Onwuteaka-Philipsen BD, Rurup ML, Buiting HM, van Delden JJ, Hanssen-de Wolf JE, Janssen AG, Pasman HR, Rietjens JA, Prins CJ, Deerenberg IM, Gevers JK, van der Maas PJ, van der Wal G: End-of-life practices in the Netherlands under the Euthanasia Act. N Engl J Med. 2007, 356: 1957-1965. 10.1056/NEJMsa071143.View ArticlePubMedGoogle Scholar
- Kuhse H, Singer P, Baume P, Clark M, Rickard M: End-of-life decisions in Australian medical practice. Med J Aust. 1997, 166: 191-196.PubMedGoogle Scholar
- Meier DE, Emmons CA, Wallenstein S, Quill T, Morrison RS, Cassel CK: A national survey of physician-assisted suicide and euthanasia in the United States. N Engl J Med. 1998, 338: 1193-1201. 10.1056/NEJM199804233381706.View ArticlePubMedGoogle Scholar
- Emanuel EJ: Euthanasia and physician-assisted suicide: a review of the empirical data from the United States. Arch Intern Med. 2002, 162: 142-152. 10.1001/archinte.162.2.142.View ArticlePubMedGoogle Scholar
- Miccinesi G, Rietjens JA, Deliens L, Paci E, Bosshard G, Nilstun T, Norup M, van der Wal G: Continuous deep sedation: physicians' experiences in six European countries. J Pain Symptom Manage. 2006, 31: 122-129. 10.1016/j.jpainsymman.2005.07.004.View ArticlePubMedGoogle Scholar
- Emanuel EJ, Fairclough D, Clarridge BC, Blum D, Bruera E, Penley WC, Schnipper LE, Mayer RJ: Attitudes and practices of U.S. oncologists regarding euthanasia and physician-assisted suicide. Ann Intern Med. 2000, 133: 527-532.View ArticlePubMedGoogle Scholar
- Onwuteaka-Philipsen BD, Fisher S, Cartwright C, Deliens L, Miccinesi G, Norup M, Nilstun T, van der Heide A, van der Wal G: End-of-life decision making in Europe and Australia: a physician survey. Arch Intern Med. 2006, 166: 921-929. 10.1001/archinte.166.8.921.View ArticlePubMedGoogle Scholar
- Bilsen J, Vander SR, Broeckaert B, Mortier F, Deliens L: Changes in medical end-of-life practices during the legalization process of euthanasia in Belgium. Soc Sci Med. 2007, 65: 803-808. 10.1016/j.socscimed.2007.04.016.View ArticlePubMedGoogle Scholar
- Cohen J, Bilsen J, Fisher S, Löfmark R, Norup M, Heide van der A, Miccinesi G, Deliens L: End-of-life decision making in Belgium, Denmark, Sweden and Switzerland: does place of death make a difference?. Journal of Epidemiology and Community Health. 2007, 61: 1062-1068. 10.1136/jech.2006.056341.View ArticlePubMedPubMed CentralGoogle Scholar
- Block van der L, Bilsen J, Deschepper R, Kelen van der G, Bernheim JL, Deliens L: End-of-life decisions among cancer patients compared with noncancer patients in Flanders, Belgium. J Clin Oncol. 2006, 24: 2842-2848. 10.1200/JCO.2005.03.7531.View ArticlePubMedGoogle Scholar
- Ganz FD, Benbenishty J, Hersch M, Fischer A, Gurman G, Sprung CL: The impact of regional culture on intensive care end of life decision making: an Israeli perspective from the ETHICUS study. J Med Ethics. 2006, 32: 196-199. 10.1136/jme.2005.012542.View ArticlePubMedPubMed CentralGoogle Scholar
- Sprung CL, Cohen SL, Sjokvist P, Baras M, Bulow HH, Hovilehto S, Ledoux D, Lippert A, Maia P, Phelan D, Schobersberger W, Wennberg E, Woodcock T: End-of-life practices in European intensive care units: the Ethicus Study. JAMA. 2003, 290: 790-797. 10.1001/jama.290.6.790.View ArticlePubMedGoogle Scholar
- Belgisch Staatsblad 22 juni 2002 [Belgian official collection of the laws June 22 2002]. Wet betreffende euthanasie 28 mei 2002 [Law concerning euthanasia May 28, 2002] (in Dutch). Number Bill 2002009590, Brussels, Belgium. 2002
- Belgisch Staatsblad 26 oktober 2002 [Belgian official collection of the laws Octobre 26 2002]. Wet betreffende palliative zorg 14 juni 2002 [Law concerning palliative care Belgium June 14, 2002] (in Dutch). Number Bill 002022868, Brussels, Belgium. 2002
- Van Oyen H, Bossuyt N, Deboosere P, Gadeyne S, Abatih E, Demarest SS: Differential inequity in health expectancy by region in Belgium. Soz Praventivmed. 2005, 50: 301-310. 10.1007/s00038-005-5017-y.View ArticlePubMedGoogle Scholar
- Flemish Agency for Care and Health. Policy and legislation. 2008, [http://www.zorg-en-gezondheid.be/]
- Deschouwer K: Ethnic structure, inequality and governance of the public sector in Belgium. 2004, Brussels, Belgium: United Nations Research Institute for Social Development.Google Scholar
- Federale controle- en evaluatiecommissie euthanasie [Federal control and evaluation commission euthanasia]. Eerste verslag van de wetgevende kamers 22 september 2002 – 31 december 2003 [First report of the legislative chambers Septembre 22, 2002 – December 31, 2003] (in Dutch). 2004, Brussels: Belgium: Federal control and evaluation commissioneuthanasia
- Federale controle- en evaluatiecommissie euthanasie [Federal control and evaluation commission euthanasia]. Eerste verslag van de wetgevende kamers 2004 – 2005 ]Second report of the legislative chambers 2004 – 2005] (in Dutch). 2006, Brussels: Belgium: Federal control and evaluation commission euthanasia
- Englert M: La pratique dépénalisée de l'euthansie en Belgique: évolution de 2002 à 2005 et interprétation des différences entre le Nord en le Sud du pays. Revue Médical de Bruxelles. 2007, 28: 423-430.Google Scholar
- Bayingana K, Demarest S, Gisle L, Hesse E, Miermans PJ, Tafforeau J, Heyden Van der J: Health survey interview, Belgium 2004. Depotn° : D/2006/2505/4, IPH/EPI REPORTS N° 2006 – 035. 2006, Brussels, Belgium: Scientific Institute of Public Health Belgium, Department ofEpidemiology.Google Scholar
- Lobet MP, Stroobant A, Mertens R, Van Casteren V, Walckiers D, Masuy-Stroobant G, Cornelis R: Tool for validation of the network of sentinel general practitioners in the Belgian health care system. Int J Epidemiol. 1987, 16: 612-618. 10.1093/ije/16.4.612.View ArticlePubMedGoogle Scholar
- Devroey D, Van Casteren V, Buntinx F: Registration of stroke through the Belgian sentinel network and factors influencing stroke mortality. Cerebrovasc Dis. 2003, 16: 272-279. 10.1159/000071127.View ArticlePubMedGoogle Scholar
- Van den Block L, Van Casteren V, Deschepper R, Bossuyt N, Drieskens K, Bauwens S, Bilsen J, Deliens L: Nationwide monitoring of end-of-life care via the Sentinel Network of General Practitioners in Belgium: the research protocol of the SENTI-MELC study. BMC Palliat Care. 2007, 6: 6-10.1186/1472-684X-6-6.View ArticlePubMedPubMed CentralGoogle Scholar
- Boffin N, Bossuyt N, Van Casteren V: Current characteristics and evolution of the Sentinel General Practitioners: data gathered in 2005 [Huidige kenmerken en evolutie van de peilartsen en hun praktijk. Gegevens verzameld in 2005]. IPH/EPI REPORTS N° 2007 – 013. 2007, Brussels, Belgium: Scientific Institute of Public Health Belgium; Unit of Epidemiology;, Accessed March 10, 2008, [http://www.iph.fgov.be/epidemio/epinl/medvnl/profil_05.pdf]Google Scholar
- Borgsteede SD, Deliens L, Francke AL, Stalman WA, Willems DL, van Eijk JT, van der Wal G: Defining the patient population: one of the problems for palliative care research. Palliat Med. 2006, 20: 63-68. 10.1191/0269216306pm1112oa.View ArticlePubMedGoogle Scholar
- Van den Block L, Deschepper R, Bilsen J, Van Casteren V, Deliens L: Transitions between care settings at the end of life in belgium. JAMA. 2007, 298: 1638-1639. 10.1001/jama.298.14.1638.View ArticlePubMedGoogle Scholar
- Van den Block L, Deschepper R, Drieskens K, Bauwens S, Bilsen J, Bossuyt N, Deliens L: Hospitalisations at the end of life: using a sentinel surveillance network to study hospital use and associated patient, disease and healthcare factors. BMC Health Serv Res. 2007, 7: 69-10.1186/1472-6963-7-69.View ArticlePubMedPubMed CentralGoogle Scholar
- Van den Block L, Deschepper R, Bossuyt N, Drieskens K, Bauwens S, Van Casteren V, Deliens L: Care for patients in the last months of life: the Belgian Sentinel Network Monitoring End-of-Life Care study. Arch Intern Med. 2008, 168: 1747-1754. 10.1001/archinte.168.16.1747.View ArticlePubMedGoogle Scholar
- Earle CC, Ayanian JZ: Looking back from death: the value of retrospective studies of end-of-life care. J Clin Oncol. 2006, 24: 838-840. 10.1200/JCO.2005.03.9388.View ArticlePubMedGoogle Scholar
- Rietjens JA, van Delden JJ, van der Heide A, Vrakking AM, Onwuteaka-Philipsen BD, van der Maas PJ, van der Wal G: Terminal sedation and euthanasia: a comparison of clinical practices. Arch Intern Med. 2006, 166: 749-753. 10.1001/archinte.166.7.749.View ArticlePubMedGoogle Scholar
- Rietjens JA, van der HA, Vrakking AM, Onwuteaka-Philipsen BD, van der Maas PJ, van der Wal G: Physician reports of terminal sedation without hydration or nutrition for patients nearing death in the Netherlands. Ann Intern Med. 2004, 141: 178-185.View ArticlePubMedGoogle Scholar
- Yaguchi A, Truog RD, Curtis JR, Luce JM, Levy MM, Melot C, Vincent JL: International differences in end-of-life attitudes in the intensive care unit: results of a survey. Arch Intern Med. 2005, 165: 1970-1975. 10.1001/archinte.165.17.1970.View ArticlePubMedGoogle Scholar
- Payer L: Medicine and culture: notions of health and sickness. 1990, London: Victor Gollancz LtdGoogle Scholar
- Deliens L, van der Wal G: The euthanasia law in Belgium and the Netherlands. Lancet. 2003, 362: 1239-1240. 10.1016/S0140-6736(03)14520-5.View ArticlePubMedGoogle Scholar
- Deschepper R, Stichele Vander R, Bernheim JL, De Keyser E, Kelen Van der G, Mortier F, Deliens L: Communication on end-of-life decisions with patients wishing to die at home: the making of a guideline for GPs in Flanders, Belgium. Br J Gen Pract. 2006, 56: 14-19.PubMedPubMed CentralGoogle Scholar
- Sahlberg-Blom E, Ternestedt BM, Johansson JE: The last month of life: continuity, care site and place of death. Palliat Med. 1998, 12: 287-296. 10.1191/026921698668132632.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/9/79/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.