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Table 4 Medical risk factors – medication, allergies, invasive procedures, injections, blood transfusions, cigarettes and illegal drugs

From: A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: analysis of potential risk factors with regard to an increased CJD incidence in the years 2001–2004

    

comparison with all control subjects

risk factor

n total

mean (SD) or %

crude estimate

age and sex adjusted estimate

age, sex and education adjusted estimate

  

cases n = 69

controls

n = 224

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

regular GP visits1

292

61.8

20.1

6.43 (3.57–11.57)

0.000

6.44 (3.57–11.62)

0.000

6.33 (3.44–11.64)

0.000

regular medication

291

86.6

75.9

2.05 (0.95–4.40)

0.067

2.30 (1.05–5.05)

0.037

2.30 (1.04–5.10)

0.040

hormones, ever

292

14.7

22.3

0.60 (0.29–1.26)

0.177

0.66 (0.29–1.50)

0.319

0.67 (0.28–1.61)

0.366

allergies2

135

9.1

14.5

0.59 (0.20–1.73)

0.336

0.66 (0.22–2.05)

0.477

0.59 (0.18–1.95)

0.383

visit to a urologist3

171

32.6

39.8

0.73 (0.35–1.51)

0.395

0.75 (0.35–1.58)

0.447

0.79 (0.36–1.74)

0.559

visit to a psychiatrist

292

14.7

12.5

1.21 (0.55–2.63)

0.636

1.16 (0.53–2.58)

0.707

1.33 (0.57–3.12)

0.509

contact lenses

291

1.5

4.5

0.32 (0.04–2.58)

0.287

0.37 (0.05–3.02)

0.355

0.47 (0.06–3.86)

0.482

regular injections

290

16.7

23.2

0.66 (0.32–1.36)

0.259

0.68 (0.33–1.39)

0.285

0.65 (0.31–1.37)

0.256

vaccinations (> 1980)

288

64.1

63.0

1.05 (0.59–1.87)

0.870

1.03 (0.58–1.85)

0.915

1.10 (0.61–2.00)

0.753

acupuncture, ever

290

13.6

21.9

0.56 (0.26–1.22)

0.145

0.57 (0.26–1.26)

0.167

0.60 (0.27–1.34)

0.211

lumbar puncture, ever

289

10.8

25.5

0.35 (0.15–0.82)

0.015

0.34 (0.15–0.80)

0.013

0.32 (0.13–0.79)

0.013

blood transfusions

291

22.4

26.8

0.79 (0.41–1.50)

0.471

0.83 (0.43–1.58)

0.563

0.81 (0.41–1.56)

0.522

blood transfusions (> 1980)

291

6.0

11.6

0.48 (0.16–1.44)

0.191

0.52 (0.17–1.55)

0.240

0.51 (0.17–1.54)

0.231

blood donation

290

16.7

47.8

0.22 (0.11–0.44)

0.000

0.16 (0.07–0.33)

0.000

0.16 (0.07–0.34)

0.000

invasive dental treatment (> 1980)

290

78.8

62.5

2.23 (1.16–4.27)

0.016

2.25 (1.17–4.32)

0.015

2.63 (1.33–5.19)

0.006

tattoo's

290

1.5

1.8

0.85 (0.09–7.70)

0.882

0.91 (0.10–8.34)

0.933

0.87 (0.09–8.14)

0.906

piercings/earrings

290

13.4

19.6

0.63 (0.29–1.38)

0.251

0.73 (0.30–1.78)

0.483

0.73 (0.29–1.83)

0.503

current cigarette smoker

284

13.3

29.0

0.38 (0.17–0.84)

0.016

0.34 (0.15–0.76)

0.009

0.34 (0.15–0.78)

0.010

illegal drugs

289

1.5

4.5

0.33 (0.04–2.66)

0.301

0.32 (0.04–2.53)

0.278

0.37 (0.05–3.04)

0.355

  1. 1) other than for CJD 2) GP controls only 3) male subjects only