Table 2 Adjusted geometric means (95% confidence interval) by quartile of creatinine corrected urinary cadmium
Quartile 1 < 0.18 μg/g | Quartile 2 0.18–0.33 μg/g | Quartile 3 0.34–0.62 μg/g | Quartile 4 ≥ 0.63 μg/g | p-trend | |
|---|---|---|---|---|---|
Total testosterone, ng/mL | |||||
Age and race-ethnicity adjusted | 4.69 (4.40, 4.99) | 4.85 (4.45, 5.27) | 5.13 (4.78, 5.52) | 5.64 (5.27, 6.04) | < 0.001 |
Multivariable model 1† | 5.06 (4.78, 5.36) | 5.06 (4.71, 5.44) | 5.03 (4.68, 5.41) | 5.09 (4.69, 5.53) | 0.88 |
Multivariable model 2‡ | 5.10 (4.85, 5.35) | 5.07 (4.72, 5.45) | 5.00 (4.67, 5.35) | 5.08 (4.68, 5.51) | 0.99 |
Total estradiol, pg/mL | |||||
Age and race-ethnicity adjusted | 32.1 (29.6, 34.8) | 34.6 (33.1, 36.1) | 37.5 (35.8, 39.2) | 39.8 (37.9, 41.8) | < 0.001 |
Multivariable model 1† | 34.4 (32.2, 36.8) | 36.1 (34.6, 37.7) | 36.9 (35.2, 38.6) | 36.2 (33.8, 38.7) | 0.42 |
Multivariable model 2‡ | 34.3 (32.3, 36.4) | 36.0 (34.5, 37.6) | 37.1 (35.4, 38.8) | 36.1 (33.7, 38.8) | 0.41 |
SHBG, nmol/L | |||||
Age and race-ethnicity adjusted | 34.2 (31.4, 37.2) | 33.1 (30.9, 35.4) | 34.6 (32.6, 36.7) | 37.5 (34.6, 40.7) | 0.009 |
Multivariable model 1† | 35.2 (32.1, 38.6) | 33.9 (31.6, 36.3) | 34.4 (32.3, 36.7) | 35.6 (32.7, 38.8) | 0.57 |
Multivariable model 2‡ | 35.5 (32.7, 38.5) | 34.0 (31.7, 36.4) | 34.3 (32.4, 36.3) | 35.4 (32.5, 38.5) | 0.71 |
Androstanediol glucuronide, ng/mL | |||||
Age and race-ethnicity adjusted | 13.0 (12.2, 13.8) | 11.8 (10.9, 12.9) | 10.9 (9.5, 12.5) | 11.2 (9.7, 13.0) | 0.23 |
Multivariable model 1† | 12.9 (12.1, 13.8) | 11.8 (10.8, 12.9) | 10.9 (9.5, 12.5) | 11.3 (9.8, 13.1) | 0.33 |
Multivariable model 2‡ | 12.9 (12.1, 13.7) | 11.7 (10.8, 12.8) | 10.9 (9.5, 12.5) | 11.4 (9.8, 13.2) | 0.40 |
Estimated free testosterone, ng/mL | |||||
Age and race-ethnicity adjusted | 0.092 (0.087, 0.097) | 0.098 (0.091, 0.105) | 0.104 (0.095, 0.113) | 0.109 (0.102, 0.118) | < 0.001 |
Multivariable model 1† | 0.099 (0.094, 0.105) | 0.102 (0.095, 0.108) | 0.101 (0.093, 0.111) | 0.100 (0.091, 0.109) | 0.89 |
Multivariable model 2‡ | 0.100 (0.094, 0.105) | 0.102 (0.095, 0.109) | 0.101 (0.092, 0.110) | 0.100 (0.090, 0.110) | 0.85 |
Estimated free estradiol, pg/mL | |||||
Age and race-ethnicity adjusted | 0.81 (0.75, 0.89) | 0.89 (0.84, 0.93) | 0.96 (0.91, 1.02) | 1.00 (0.94, 1.07) | < 0.001 |
Multivariable model 1† | 0.87 (0.81, 0.94) | 0.92 (0.87, 0.97) | 0.95 (0.90, 1.00) | 0.91 (0.84, 0.99) | 0.69 |
Multivariable model 2‡ | 0.87 (0.81, 0.93) | 0.92 (0.87, 0.97) | 0.95 (0.90, 1.01) | 0.91 (0.83, 1.00) | 0.69 |
Estradiol*1000/total testosterone | |||||
Age and race-ethnicity adjusted | 7.24 (6.57, 7.99) | 7.56 (6.81, 8.39) | 7.74 (7.18, 8.34) | 7.47 (6.98, 8.00) | 0.80 |
Multivariable model 1† | 7.20 (6.55, 7.91) | 7.55 (6.83, 8.34) | 7.75 (7.14, 8.42) | 7.52 (6.90, 8.20) | 0.70 |
Multivariable model 2‡ | 7.12 (6.60, 7.69) | 7.52 (6.80, 8.31) | 7.85 (7.23, 8.53) | 7.54 (6.86, 8.28) | 0.61 |
Total testosterone/SHBG | |||||
Age and race-ethnicity adjusted | 0.476 (0.445, 0.510) | 0.508 (0.475, 0.543) | 0.514 (0.469, 0.564) | 0.522 (0.480, 0.566) | 0.05 |
Multivariable model 1† | 0.498 (0.461, 0.538) | 0.518 (0.488, 0.551) | 0.507 (0.460, 0.558) | 0.495 (0.444, 0.553) | 0.71 |
Multivariable model 2‡ | 0.498 (0.461, 0.538) | 0.518 (0.485, 0.554) | 0.505 (0.458, 0.555) | 0.497 (0.442, 0.559) | 0.79 |
Estradiol*1000/SHBG | |||||
Age and race-ethnicity adjusted | 3.45 (3.03, 3.92) | 3.84 (3.52, 4.20) | 3.98 (3.66, 4.32) | 3.90 (3.49, 4.35) | 0.15 |
Multivariable model 1† | 3.59 (3.14, 4.09) | 3.91 (3.56, 4.30) | 3.93 (3.60, 4.28) | 3.72 (3.29, 4.22) | 0.98 |
Multivariable model 2‡ | 3.55 (3.16, 3.99) | 3.90 (3.55, 4.28) | 3.97 (3.66, 4.30) | 3.75 (3.29, 4.27) | 0.87 |