Parameter | Value (Base Case) | Source(s) |
---|---|---|
Population meeting fiber recommendations | Â | Â |
  Adult, male | 3% | USDA, 2010 [2] |
  Adult, female | 6% | USDA, 2010 [2] |
  Pediatric, male | 3% | USDA, 2010 [2] |
  Pediatric, female | 3% | USDA, 2010 [2] |
Population with constipation | Â | Â |
  Adult, male | 4.6% | Stewart et al., 1999 [22] |
  Adult, female | 4.6% | Stewart et al., 1999 [22] |
  Pediatric, male | 4.6% | Based on Stewart et al., 1999 [22] |
  Pediatric, female | 4.6% | Based on Stewart et al., 1999 [22] |
Percent of population expected to respond to fibera | 85% | Voderholzer et al. 1997 [30] |
Percent reduction in constipation associated with each 1Â g/day increase in fiber intake | 1.9% | Dukas et al. 2003 [18] |
Constipation severity | Â | Â |
  Adults | 75% require prescription | Assumption |
  Pediatric | 100% require prescription | Assumption |
Annual cost | Â | Â |
  Adult, prescription | $10,786.15 | Mean of Mitra et al., 2011 [31] and Nyrop et al. 2007 [32], inflated to 2012 |
  Adult, OTC | $566.54 | Nyrop et al. 2007 [32], inflated to 2012 |
  Pediatric, prescription | $3032.97 | Liem et al., 2009 [33], inflated to 2012 |
Change in fiber intake | Increase of 9Â g daily | Assumptionb |