Table 4 Application of CHERG Rules for selection of point estimate for sepsis mortality for inclusion to LiST model [7]
Outcome measure | Studies | Total Events | Effect size | GRADE quality of pooled estimate | Application of standard rules |
|---|---|---|---|---|---|
Sepsis specific neonatal mortality | (n=1) | Not reported | 31 % reduction, statistically non-significant (RR=0.69, 95 % CI 0.40-1.18) | Low | Effect size for sepsis specific mortality was not used for inclusion in LiST model as results were not statistically significant and overall quality grade was “low” |
All cause neonatal mortality | (n=3) | 838 | 23% reduction, Statistically significant (RR=0.77, 95 % CI 0.63 - 0.94) | Moderate → Low | Effect size for all-cause mortality was used for inclusion to LiST model. This was based on rule 1 that says that if there is no evidence for cause specific mortality and there is evidence for all-cause mortality, use the effect size for all-cause and down grade quality grade by one. |