Days and suggested times | Sampling | Procedure |
---|---|---|
45, 76, 108 | ||
1700 h (check in) | Blood, urine | Measure BP, PR, RR and temperature; abbreviated physical examination and medical history; illicit drug, alcohol and cotinine testing; pregnancy testing; collection of diary and cigarette butts; clinical laboratory tests; electrocardiography; lung- function tests; dinner |
1900 h | None | Start 24 h urine collection, monitoring of cigarette consumption and collection of filters |
2100 h | None | Snack |
46, 77, 109 | ||
0700 h | Blood | Measure BP, PR, RR and temperature; measure creatinine in serum; biomarkers and gene expression |
0800 h | None | Breakfast |
1000 h | None | Administer sensory questionnaire; administer quality-of-life and diet and lifestyle questionnairesa |
1200 h | None | Lunch |
1500 h | None | Measure exhaled CO |
1700 h | Saliva | Cotinine testing; dinner |
1900 h | None | End 24 h urine collection, monitoring of cigarette consumption and collection of filters; dispense interventional products and cigarette butt collection tins for use at home, remind participants of instructions for diet and completion of diaries |