INTEROCC case–control study: lack of association between glioma tumors and occupational exposure to selected combustion products, dusts and other chemical agents

Lacourt, Aude; Cardis, Elisabeth; Pintos, Javier; Richardson, Lesley; Kincl, Laurel; Benke, Geza; Fleming, Sarah; Hours, Martine; Krewski, Daniel; McLean, Dave; Parent, Marie-Elise; Sadetzki, Siegal; Schlaefer, Klaus; Schlehofer, Brigitte; Lavoue, Jerome; van Tongeren, Martie; Siemiatycki, Jack

doi:10.1186/1471-2458-13-340

Table 2 Association between 10 occupational agents and glioma in the seven-country INTEROCC study – five year lag period

From: INTEROCC case–control study: lack of association between glioma tumors and occupational exposure to selected combustion products, dusts and other chemical agents

	Formaldehyde						Oil mist
	Cases (1,800)		Controls (5,160)		OR ^d	95% CI	Cases (1,800)		Controls (5,160)		OR	95% CI
	n	% ^c	n	%			n	%	n	%
Non exposed	1586	88.1	4639	89.9	1.0	-	1657	92.1	4810	93.2	1.0	-
Ever exposed ^a	96	5.3	283	5.5	0.8	0.6-1.1	63	3.5	151	2.9	0.8	0.6-1.1
Cumulative exposure ^b
Lowest tertile	32	1.8	99	1.9	0.9	0.6-1.3	12	0.7	50	1.0	0.5	0.3-1.0
Middle tertile	28	1.6	88	1.7	0.8	0.5-1.4	24	1.3	49	0.9	1.0	0.6-1.7
Highest tertile	34	1.9	94	1.8	0.7	0.5-1.1	23	1.3	50	1.0	0.9	0.5-1.6
Duration (years)
1 - 4	28	1.6	106	2.1	0.7	0.5-1.1	14	0.8	52	1.0	0.5	0.3-0.9
5 - 9	22	1.2	85	1.6	0.6	0.4-1.1	22	1.2	47	0.9	1.1	0.6-1.8
≥ 10	44	2.4	90	1.7	1.1	0.7-1.7	23	1.3	50	1.0	0.9	0.5-1.6
	Diesel exhaust emissions						Gasoline exhaust emissions
Non exposed	1458	81.0	4446	86.2	1.0	-	1558	86.6	4654	90.2	1.0	-
Ever exposed ^a	201	11.2	427	8.3	1.0	0.8-1.2	191	10.6	415	8.0	1.0	0.8-1.2
Cumulative exposure ^b
Lowest tertile	47	2.6	140	2.7	0.7	0.5-1.0	48	2.7	135	2.6	0.8	0.5-1.1
Middle tertile	73	4.1	139	2.7	1.2	0.9-1.7	68	3.8	135	2.6	1.1	0.8-1.5
Highest tertile	77	4.3	143	2.8	1.1	0.8-1.5	71	3.9	139	2.7	1.0	0.7-1.4
Duration (years)
1 - 4	57	3.2	153	3.0	0.8	0.6-1.2	51	2.8	135	2.6	0.8	0.6-1.2
5 - 9	55	3.1	126	2.4	0.9	0.6-1.2	56	3.1	137	2.7	0.8	0.6-1.2
≥ 10	85	4.7	143	2.8	1.3	1.0-1.8	80	4.4	137	2.7	1.3	0.9-1.8
	Benzo(a)pyrene						Sulphur dioxide
Non exposed	221	12.3	667	12.9	1.0	-	1775	98.6	5124	99.3	1.0	-
Ever exposed ^a	367	20.4	1056	20.5	0.8	0.6-1.0	20	1.1	19	0.4	2.0	1.0-3.8
Cumulative exposure ^b
Lowest tertile	94	5.2	344	6.7	0.7	0.5-0.9	11	0.6	7	0.1	3.1	1.2-8.5
Middle tertile	118	6.6	344	6.7	0.8	0.6-1.1	3	0.2	6	0.1	1.2	0.3-5.0
Highest tertile	149	8.3	353	6.8	0.9	0.7-1.2	6	0.3	6	0.1	1.4	0.4-4.7
Duration (years)
1 - 4	99	5.5	383	7.4	0.6	0.5-0.9	15	0.8	7	0.1	4.4	1.7-11.2
5 - 9	126	7.0	305	5.9	1.0	0.8-1.4	2	0.1	6	0.1	0.3	0.0-2.2
≥ 10	136	7.6	353	6.8	0.8	0.6-1.1	3	0.2	6	0.1	1.1	0.3-4.6
	Asbestos						Crystalline silica
Non exposed	1352	75.1	4204	81.5	1.0	-	1579	87.7	4712	91.3	1.0	-
Ever exposed ^a	292	16.2	621	12.0	0.9	0.8-1.1	200	11.1	413	8.0	1.0	0.8-1.2
Cumulative exposure ^b
Lowest tertile	89	4.9	210	4.1	0.8	0.6-1.1	54	3.0	135	2.6	0.8	0.3-1.2
Middle tertile	100	5.6	200	3.9	1.1	0.8-1.4	68	3.8	135	2.6	1.1	0.8-1.5
Highest tertile	103	5.7	211	4.1	1.0	0.7-1.3	74	4.1	138	2.7	1.1	0.8-1.5
Duration (years)
1 - 4	84	4.7	219	4.2	0.9	0.6-1.1	52	2.9	135	2.6	0.9	0.6-1.2
5 - 9	104	5.8	191	3.7	1.0	0.7-1.3	61	3.4	136	2.6	0.9	0.7-1.3
≥ 10	104	5.8	211	4.1	1.0	0.8-1.3	83	4.6	137	2.7	1.2	0.9-1.7
	Wood dust						Animal dust
Non exposed	1706	94.8	4933	95.6	1.0	-	1733	96.3	5006	97.0	1.0	-
Ever exposed ^a	88	4.9	204	4.0	1.1	0.8-1.5	66	3.7	147	2.8	0.6	0.6-1.2
Cumulative exposure ^b
Lowest tertile	31	1.7	66	1.3	1.1	0.7-1.8	18	1.0	49	0.9	0.7	0.4-1.4
Middle tertile	31	1.7	66	1.3	1.1	0.7-1.8	24	1.3	49	0.9	0.9	0.5-1.5
Highest tertile	26	1.4	68	1.3	1.1	0.6-1.7	23	1.3	49	0.9	0.9	0.5-1.5
Duration (years)
1 - 4	32	1.8	69	1.3	1.1	0.7-1.7	25	1.4	55	1.1	0.8	0.4-1.5
5 - 9	27	1.5	63	1.2	1.1	0.7-1.8	17	0.9	43	0.8	0.9	0.5-1.6
≥ 10	29	1.6	68	1.3	1.1	0.7-1.8	23	1.3	49	0.9	0.8	0.4-1.4

^a Probability of exposure in the modified version of FINJEM ≥ 25%; duration ≥ 1 year; lag period of 5 years.
^b Calculated among exposed subject as ∑Probability × Level × Duration of each job held by a subject; cut-points at tertiles among exposed controls; expressed in mg/m³ (oil mist, diesel and gasoline exhaust emissions, crystalline silica, wood dust and animal dust); ppm (formaldehyde, sulphur dioxide); μg/ m³ (benzo(a)pyrene) or in fibers/m³ (asbestos).
^c Percentages may not add up to 100 due to the exclusion of subjects classified as having ‘uncertain’ exposure.
^d Odds ratios stratified by sex, age (5-year categories) and center and adjusted for age as a continuous variable, the maximum education level attained in the household, the standard international occupational prestige scale, atopy and the respondent status.

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