This study is a cross-sectional study and a questionnaire was used to collect the data. The response rate, nearly 80%, is consistent with what is common in similar studies. In this study, the women were somewhat older than the men and were also more often retired due to the disease, while more men reported they had work capacity. Regarding civil status, level of education, course of disease and disability or pharmacological treatment, there were no significant differences between women and men, except for work capacity.
Fatigue proved to be a significant factor influencing work capacity. Those participants who had the capacity to work reported significantly less fatigue compared to those with no capacity to work. Another fact was that the level of work capacity was statistically significantly higher among those participants who were not sensitive to heat, while those who were sensitive to heat showed significantly more often a non-capacity to work. In a previous study, heat sensitivity was found to significantly interfere with and also increase fatigue . In this study, fatigue could be seen as a key symptom influencing both work capacity and HRQoL.
Similar to the findings in this study, Krokavcova et al.  found that patients with self-rated good health are more likely to be employed. In this study, participants who had the capacity to work graded both better health and HRQoL than those with a non-capacity to work.
Interestingly, a higher level of education was shown as a significant predictive factor for work capacity in this study. The reason for this may be discussed in terms of disability level and work of a person, which demands that the person is movable, or that educational attainment has not been disrupted due to MS. This might be dependent of the age at onset of the disease . In the present study, just a few percent of the participants (5.5%) had onset of the disease before 20 years of age . Blue collar work usually consists of physical labor which naturally is influenced by actual disability, while work requiring higher education might more often be paperwork or white collar work. This result indicates the importance of supporting young MS-patients in continuing their education, even at a higher level. This would also be in line with the results presented by Glad and colleagues , who found that having a RR-course, higher education and light physical work were predicting factors for being able to remain employed.
Another interesting aspect of the increased work capacity of patients with higher education is that cognitive problems in MS are a common feature. However, obviously, in this study, such problems did not interfere with work, probably based on intellectual processes, which required higher education. However, MS is a complex disease and regarding fatigue, multiple factors might interact and influence both fatigue and cognitive function. In this study in the linear regression analysis, fatigue and cognition were found as contributing factors in the domain of bodily pain and vitality. Pain may interfere with and disrupt an individual’s attention and concentration, but also influence fatigue. An important question is if cognitive problems in MS sometimes fluctuate and are secondary to fatigue. This should be of interest to study further. However, fluctuations of cognitive difficulties in MS have been found in relation to a heat environment [31–33]. In one study, cognitive difficulties were reported as eased when the individual used a cooling-suit , which also should be of interest for further investigations.
Age appeared as a predictor for capacity for work. In a correlation analysis we found that age and having children were closely correlated (rs = 0.78) why we chose to keep age as the independent variable. In our original hypothesis, however, we paid an interest in MS patients with small children since this situation may increase their level of fatigue. As age appeared as a predictor we also suggest that it stands for having small children.
Quality of life was assessed as significantly higher among those who worked, a result also found in earlier studies. Obvious in this study was that fatigue was a significant factor influencing all domains of health-related quality of life, except role-emotional and mental health, while cognition was a significant factor influencing two of the domains, bodily pain and vitality. In the domain of role-emotional, heat sensitivity appeared as a significant influencing factor which might be understood as limiting the individuals’ social life activities.
The impact of fatigue on quality of life is obviously connected to work ability, a central function in everybody’s life. For natural reasons, the risk of isolation in society increases both through unemployment and the obstacles it places to participating in family life on equal terms. In conclusion, the impact on these domains could very well affect the individual’s sense of coherence which is central to the individual’s perception of wellbeing. As fatigue is a symptom with a severe impact on quality of life and work capacity, it is important to find the organic cause which, in the case of MS, justifies a patient’s sick leave and disability pension.
Another point of view is that being able to work is of importance for the quality of life of people with chronic diseases. People with MS, should have the opportunity to work part-time as long as possible. As people with MS are often affected early on in life, their occupational development is more difficult. The fact that young people may be stopped by MS from working at all should also be taken into account.
Apart from disability measured by EDSS, the fact that heat sensitivity interferes with work capacity suggests that organising cryotherapeutic approaches in the work place, such as air conditioning, cooling garments and disability friendly measures should be put in place.
This article also focuses on fatigue as a common and serious symptom in MS already at the onset and the following stages of the disease. For example, general practitioners should take MS-fatigue into consideration when young patients complain about tiredness. Subsequently, it is necessary that patients are properly diagnosed early on in the course of a disease like MS, indicating that physicians should be careful when diagnosing a common symptom like tiredness or mental/physical exhaustion in young people, especially females. However, all patients who complain of fatigue cannot be referred to a neurologist. The Swedish sick leave system relies on patients being diagnosed. Clear recommendations are made in order to determine the appropriate sick leave period with a specific diagnosis. This means that a patient without a specific diagnosis, i.e. a rather symptomatic description, like tiredness, pain, etc., may find it difficult to receive financial compensation from the Swedish sick leave insurance system. One study from our group has revealed that although a very high percentage of MS patients showed no sign of neurological dysfunction when physically examined, in fact, almost 25%, suffered from pathological tiredness – fatigue – as the only subjective symptom .
A limitation of the study is associated with the chosen design, no causal explanations and no follow up. The sample included 323 individuals why self-assessment questionnaires were used. Thus, data rely on self-assessments and on the subjective experiences of the participants. The use of a generic instrument to investigate HRQoL (SF36) can be criticized since it does not cover specific MS-symptoms. However, the SF36 is a well known instrument and widely used in other studies, why the results may be easier to interpret and can also be compared with other groups in the future.