Cases/controls | Crude vaccine effectiveness, % (95% CI) | p-value | Adjusted vaccine effectiveness, % (95% CI) | p-value | |
---|---|---|---|---|---|
All swabbed patients | |||||
Pandemic vaccine 2009-2010 | |||||
No | 297/260 | Ref. | Ref. | ||
Yes | 6/26 | 80 (50; 92) | <0.001 | 45 (−68; 82) a | 0.297 |
Seasonal vaccine 2010-2011 | |||||
No | 290/241 | Ref. | Ref. | ||
Yes | 13/45 | 76 (54; 87) | <0.001 | 67 (24; 86) a | 0.009 |
Patients swabbed within 4 days of symptom onset | |||||
Pandemic vaccine 2009-2010 | |||||
No | 292/250 | Ref. | Ref. | ||
Yes | 6/25 | 79 (49; 92) | 0.001 | 44 (−71; 82) a | 0.309 |
Seasonal vaccine 2010-2011 | |||||
No | 286/235 | Ref. | Ref. | ||
Yes | 12/40 | 75 (52; 87) | <0.001 | 65 (16; 85) a | 0.018 |
Influenza A(H1N1)pdm09 cases vs. controls | |||||
Pandemic vaccine 2009-2010 | |||||
No | 262/260 | Ref. | Ref. | ||
Yes | 5/26 | 81 (49; 93) | <0.001 | 60 (−30; 87) a | 0.129 |
Seasonal vaccine 2010-2011 | |||||
No | 254/241 | Ref. | Ref. | ||
Yes | 13/45 | 73 (48; 86) | <0.001 | 61 (9; 83) a | 0.030 |
Influenza B cases vs. controls | |||||
Seasonal vaccine 2010-2011 | |||||
No | 33/241 | Ref. | Ref. | ||
Yes | 0/45 | 89 (33; 100)c | 0.010 | 93 (36; 100) c,d | 0.017 |
Subjects with indication for seasonal vaccination b | |||||
Pandemic vaccine 2009-2010 | |||||
No | 82/85 | Ref. | Ref. | ||
Yes | 6/21 | 70 (24; 89) | 0.013 | 28 (−147; 79) a | 0.599 |
Seasonal vaccine 2010-2011 | |||||
No | 76/69 | Ref. | Ref. | ||
Yes | 12/37 | 71 (39; 86) | 0.001 | 64 (8; 86) a | 0.034 |
Primary health care patients | |||||
Pandemic vaccine 2009-2010 | |||||
No | 286/227 | Ref. | Ref. | ||
Yes | 4/13 | 76 (24; 92) | 0.015 | 56 (−70; 89) e | 0.231 |
Seasonal vaccine 2010-2011 | |||||
No | 280/216 | Ref. | Ref. | ||
Yes | 10/24 | 68 (31; 75) | 0.003 | 68 (17; 87) e | 0.019 |
Hospitalized patients | |||||
Pandemic vaccine 2009-2010 | |||||
No | 11/33 | Ref. | Ref. | ||
Yes | 2/13 | 54 (−137; 91) c | 0.355 | 8 (−967; 94) c,e | 1.000 |
Seasonal vaccine 2010-2011 | |||||
No | 10/25 | Ref. | Ref. | ||
Yes | 3/21 | 64 (−47; 91) c | 0.154 | 61 (−316; 98) c,e | 0.677 |
Subjects aged less than 50 years | |||||
Pandemic vaccine 2009-2010 | |||||
No | 246/191 | Ref. | Ref. | ||
Yes | 2/6 | 74 (−30; 95) | 0.100 | 60 (−65; 94) a | 0.341 |
Seasonal vaccine 2010-2011 | |||||
No | 245/188 | Ref. | Ref. | ||
Yes | 3/9 | 75 (4; 93) | 0.043 | 73 (−21; 94) a | 0.086 |
Subjects aged 50 years or older | |||||
Pandemic vaccine 2009-2010 | |||||
No | 51/69 | Ref. | Ref. | ||
Yes | 4/20 | 73 (26; 91) | 0.024 | 47 (−133; 88) a | 0.401 |
Seasonal vaccine 2010-2011 | |||||
No | 45/53 | Ref. | Ref. | ||
Yes | 10/36 | 67 (27; 85) | 0.007 | 69 (0; 91) a | 0.050 |