Genetic variability in IGF-1 and IGFBP-3 and body size in early life

Poole, Elizabeth M; Tworoger, Shelley S; Hankinson, Susan E; Baer, Heather J

doi:10.1186/1471-2458-12-659

BMC Public Health

Table 2 Associations between SNPs in IGF-1 and IGFBP-3 and body size in early life ^a

From: Genetic variability in IGF-1 and IGFBP-3 and body size in early life

			Birthweight			Average somatotype			BMI at age 18
						at ages 5 and 10
Gene	SNP	MAF	OR	95% CI	p	OR	95% CI	p	β	SE	p
IGF-1	rs1996656	0.18	0.96	(0.80-1.15)	0.64	1.03	(0.93-1.14)	0.57	−0.0068	0.0050	0.17
	rs4764695	0.50	1.06	(0.97-1.16)	0.16	1.01	(0.93-1.10)	0.75	0.0017	0.0044	0.70
	rs4764876	0.26	0.90	(0.76-1.08)	0.27	1.02	(0.93-1.11)	0.65	0.0045	0.0032	0.16
	rs2946834	0.32	0.93	(0.85-1.02)	0.12	1.00	(0.92-1.08)	0.91	0.0020	0.0029	0.49
	rs1520220	0.18	0.93	(0.83-1.04)	0.18	0.98	(0.87-1.10)	0.72	−0.0037	0.0036	0.30
	rs1549593	0.13	1.02	(0.89-1.16)	0.79	0.95^b	(0.72-1.26)	0.73	−0.0007	0.0063	0.91
	rs5742665	0.13	0.98	(0.83-1.15)	0.83	1.00	(0.90-1.13)	0.94	0.0103	0.0051	0.04
	rs2373722	0.07	0.91	(0.77-1.08)	0.28	0.88	(0.71-1.08)	0.21	−0.0027	0.0053	0.61
	rs10735380	0.27	0.93	(0.83-1.04)	0.21	0.98	(0.90-1.06)	0.58	−0.0031	0.0032	0.34
	rs2195239	0.23	0.94	(0.83-1.08)	0.39	1.01	(0.92-1.10)	0.85	−0.0043^b	0.0080	0.59
	rs1019731	0.13	1.06	(0.93-1.21)	0.35	1.09	(0.98-1.23)	0.12	0.0021	0.0041	0.61
	rs12821878	0.22	1.11	(0.99-1.23)	0.06	1.09	(0.94-1.28)	0.26	0.0030	0.0034	0.38
	rs35767	0.16	0.98	(0.87-1.12)	0.81	0.89	(0.77-1.04)	0.14	−0.0080	0.0038	0.03
	rs7965399	0.04	1.01	(0.75-1.38)	0.92	0.90	(0.75-1.09)	0.30	−0.0026	0.0067	0.70
IGFBP-1/IGFBP-3	rs4619	0.35	1.02	(0.91-1.14)	0.75	0.99	(0.84-1.17)	0.93	−0.0018	0.0029	0.54
	rs2201638	0.03	0.92	(0.57-1.48)	0.73	1.05	(0.71-1.56)	0.80	0.0257	0.0156	0.10
	rs1065780	0.38	1.02	(0.93-1.11)	0.74	1.02	(0.94-1.11)	0.55	−0.0002	0.0039	0.95
	rs1553009	0.20	1.04	(0.94-1.17)	0.44	1.10	(1.00-1.21)	0.06	0.0042	0.0035	0.23
	rs35539615	0.23	0.98	(0.87-1.10)	0.71	0.95	(0.85-1.06)	0.34	0.0018	0.0036	0.62
	rs1908751	0.30	0.97	(0.88-1.07)	0.56	0.95	(0.87-1.03)	0.20	0.0061	0.0031	0.05
	rs4988515	0.04	1.13	(0.91-1.40)	0.27	1.08	(0.89-1.33)	0.43	−0.0018	0.0111	0.87
	rs10228265	0.31	0.94	(0.86-1.03)	0.19	0.98	(0.90-1.06)	0.59	−0.0043	0.0030	0.15
	rs2270628	0.19	1.01	(0.84-1.23)	0.89	0.96	(0.87-1.06)	0.38	−0.0052	0.0064	0.42
	rs6670	0.21	0.93	(0.84-1.03)	0.18	0.99	(0.90-1.09)	0.82	0.0033	0.0043	0.44
	rs2453839	0.20	0.97	(0.86-1.08)	0.54	1.02	(0.84-1.25)	0.84	0.0113^b	0.0086	0.19
	rs3110697	0.42	0.98	(0.90-1.07)	0.63	0.94	(0.82-1.09)	0.43	−0.0055^b	0.0081	0.50
	rs2854746	0.40	1.09	(1.00-1.20)	0.06	1.02	(0.94-1.10)	0.65	0.0003	0.0029	0.91
	rs2854744	0.47	1.09	(0.90-1.32)	0.39	1.01	(0.94-1.10)	0.73	−0.0029	0.0032	0.37
	rs2132570	0.22	0.96	(0.81-1.15)	0.69	0.92	(0.83-1.03)	0.16	−0.0048	0.0049	0.33
	rs2960436	0.46	1.12	(0.93-1.34)	0.25	0.99	(0.91-1.08)	0.89	−0.0023	0.0046	0.61

^aBirthweight was categorized as <5.5 lbs, 5.5-6.9 lbs, 7-8.4 lbs, 8.5-9.9 lbs, and 10+ lbs. Somatotypes at age 5 and 10 were categorized as 1,2,3,4,5+. BMI at age 18 was log-transformed and continuous. Birthweight and somatotypes at age 5 and 10 were analyzed in ordinal logistic regression models; BMI at age 18 was analyzed in a linear regression model. All models were adjusted for age at blood draw/cheek collection, menopausal status at blood draw/cheek collection and case selection, post-menopausal hormone use at blood draw/cheek collection and control selection, and DNA source (NHS only).
^bThe NHS and NHSII cohorts were combined using meta-analysis techniques. These estimates had P-het <0.05, indicating heterogeneity between the cohorts.
Abbreviations: SNP: single nucleotide polymorphism; IGF-1: insulin-like growth factor 1; IGFBP-3: insulin-like growth factor binding protein 3; BMI: body mass index; MAF: minor allele frequency; OR: Odds Ratio; CI: confidence interval; SE: standard error.

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ISSN: 1471-2458

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