Multidisciplinary approach to management of maternal asthma (MAMMA [copyright]): the PROTOCOL for a randomized controlled trial
© Lim et al.; licensee BioMed Central Ltd. 2012
Received: 28 June 2012
Accepted: 29 November 2012
Published: 19 December 2012
Uncontrolled asthma during pregnancy is associated with the maternal hazards of disease exacerbation, and perinatal hazards including intrauterine growth restriction and preterm birth. Interventions directed at achieving better asthma control during pregnancy should be considered a high priority in order to optimise both maternal and perinatal outcomes. Poor compliance with prescribed asthma medications during pregnancy and suboptimal prescribing patterns to pregnant women have both been shown to be contributing factors that jeopardise asthma control. The aim is to design and evaluate an intervention involving multidisciplinary care for women experiencing asthma in pregnancy.
A pilot single-blinded parallel-group randomized controlled trial testing a Multidisciplinary Approach to Management of Maternal Asthma (MAMMA©) which involves education and regular monitoring. Pregnant women with asthma will be recruited from antenatal clinics in Victoria, Australia. Recruited participants, stratified by disease severity, will be allocated to the intervention or the usual care group in a 1:1 ratio. Both groups will be followed prospectively throughout pregnancy and outcomes will be compared between groups at three and six months after recruitment to evaluate the effectiveness of this intervention. Outcome measures include Asthma Control Questionnaire (ACQ) scores, oral corticosteroid use, asthma exacerbations and asthma related hospital admissions, and days off work, preventer to reliever ratio, along with pregnancy and neonatal adverse events at delivery. The use of FEV1/FEV6 will be also investigated during this trial as a marker for asthma control.
If successful, this model of care could be widely implemented in clinical practice and justify more funding for support services and resources for these women. This intervention will also promote awareness of the risks of poorly controlled asthma and the need for a collaborative, multidisciplinary approach to asthma management during pregnancy. This is also the first study to investigate the use of FEV1/FEV6 as a marker for asthma control during pregnancy.
Australian New Zealand Clinical Trials Registry (ACTRN12612000681853)
KeywordsAsthma Pregnancy Inhaled corticosteroids Randomized controlled trial Antenatal care Intervention Lung function tests Multidisciplinary care
Preterm birth and intrauterine growth restriction remain leading contributors to perinatal mortality and morbidity. Preterm birth is the leading cause of neonatal death, and over half of term stillbirths are associated with impaired fetal growth. Beyond the perinatal period, survivors of preterm birth and fetal growth restriction face a range of long term adverse health outcomes through infancy and childhood , and many adult diseases are now recognised to have their origins in fetal life [2–4]. Accordingly, continued efforts are necessary to identify interventions that may reduce the burden of preterm birth, and improve in utero fetal growth.
Poorly controlled asthma during pregnancy has been shown to be associated with an increased risk of preterm birth, low birth weight, and pre-eclampsia [5, 6]. This data suggests that improved asthma control may be a means of reducing these important perinatal outcomes and that proper asthma management among pregnant women should be regarded as a health priority. In general, they should be managed in the same way as non-pregnant women with asthma, with the exception their asthma should be monitored at least monthly, as pregnancy can have a significant effect on asthma control [7, 8]. A lack of knowledge amongst women regarding the risks of uncontrolled asthma during pregnancy is evident. Furthermore, there is a lack of confidence amongst health professionals when deciding the best management strategy for these women . These concerns need to be addressed, as a starting point to optimise asthma control during pregnancy. Strategies to improve asthma management during pregnancy are warranted.
Preventive asthma medications at regular doses have been shown to be safe to use during pregnancy and the risks of reduction or discontinuation of these medications are far worse [10, 11]. Asthma guidelines around the world strongly recommend that women continue their asthma medications during pregnancy to maintain adequate control [7, 8, 12–18]. However, women are still choosing to cease their asthma medications during pregnancy, many without consulting their doctors [19–21]. Reasons for this include concern over using any medication use during pregnancy, a desire for alternative therapies, perceptions of negative outcomes associated with steroid use, lack of support and guidance from health professionals regarding what to do with their asthma medications and the risks of poorly controlled asthma during pregnancy . Moreover, women overestimate the teratogenic risks of asthma medication especially the steroid medications, with one report citing women perceived a 42% teratogenic risk for oral corticosteroid versus 12% risk for inhaled corticosteroid .
Prescribers have also been shown to be hesitant to prescribe and encourage use of asthma medications during pregnancy. Over a quarter of family physicians have said they would instruct their pregnant patients to decrease or discontinue asthma medication during pregnancy, when asthma was well controlled by current therapy , potentially jeopardizing asthma control. Pregnant women are also less likely to be treated with systemic corticosteroids for acute asthma exacerbations than non-pregnant women (50.8% versus 72.4%) .
The uncertainty and anxiety surrounding medication use and asthma control during pregnancy emphasise the crucial role of doctors, pharmacists and midwives in ensuring patient adherence to asthma medications during pregnancy and educating them on the risks of uncontrolled asthma during pregnancy. A collaborative approach between the pregnant women, doctors, midwives and pharmacists is needed to maintain adequate asthma control. Monthly monitoring has been recommended by guidelines  to maintain optimal asthma control as different stages of pregnancy can have an effect on asthma control . We aim to test an intervention that allows for regular patient self-monitoring and a multidisciplinary health professional approach for asthma management during pregnancy; if successful it could justify funding for more support services for these women.
There also needs to be more detailed guidelines and objective measures for monitoring lung function for the treatment of pregnant women with asthma. The exhaled fraction of nitric oxide (FeNO) has been investigated as a marker for asthma control during pregnancy, but is expensive and not easily accessible . Forced Expiratory Volumes in one and six seconds (FEV1/FEV6) has shown to be effective in detecting airway obstruction in the elderly and could be helpful in pregnancy . FEV1/FEV6 may be a way of differentiating the shortness of breath associated with pregnancy from worsening asthma symptoms and a more convenient and affordable way of monitoring and guiding therapy in pregnant asthmatic women.
To determine whether a multidisciplinary approach involving asthma education and regular monitoring during pregnancy will decrease asthma exacerbations with associated maternal and perinatal benefits. We hypothesis that the intervention group will have a better mean asthma control score than the control group at three and six months.
Inclusion and exclusion criteria
Demographic and clinical characteristics of the study population at baseline
Intervention group (n=30)
Control group (n=30)
Age in years Mean [SD]
Gestational age at first visit in weeks Mean [SD]
Height in cm Mean [SD]
Adherence Score Median [IQR]
Intermittent to Mild
Moderate to Severe
ICS/LABA + SABA
FEV1 in litres Mean [SD]
FEV1%predicted Mean [SD]
FEV1/FEV6 Mean [SD]
Hypertension in pregnancy
Health Care Concession Card holders
Pregnant women who have self reported asthma will be approached at their antenatal outpatient appointment.
Advertisement posters publicising the trial will be placed in the outpatient department alongside an ‘expression of interest’ box where participants can leave their contact details. Study packs (including an explanatory statement with an expression of interest form and a reply paid envelope) will also be available in the outpatient department so potential participants can take the information home to read and post back expression of interest forms.
Midwives will also be asked to help identify eligible pregnant women with asthma during their first outpatient visit. They will be asked to approach any woman who has indicated they are asthmatic and hand them a study pack, which will be available in the outpatient department.
A list of pregnant asthmatic women who have had their first outpatient visit will be generated weekly from the medical records database which stores antenatal information for all hospital patients. Study packs will be posted to the women who are on the weekly list.
Written informed consent will be obtained from all participants. All participants will be over the age of 18 years and will have competency to consent. During the recruitment phase, each participant will be asked to nominate her preferred family physician (general practitioner) to be involved in the trial who will be the lead clinician responsible for her asthma management during pregnancy.
Participants will be asked basic questions to determine their asthma severity in accordance with the National Asthma Council Management Handbook  classifications. Participants will be stratified into two groups: mild intermittent asthmatics and moderate-severe persistent asthmatics. Within these two strata, block randomization using random blocks of four and six will be conducted using the sealed opaque envelope method. A random sequence of numbers will be generated using the Random allocation software program® by an external researcher who is not part of the research team. Only this researcher will be aware of the allocation sequence. Numbered envelopes will be opened by the leading investigator AL to allocate participants to the usual care group (UCG) or the multidisciplinary care group (MCG) at time of recruitment and will enrol the participant into the study. Stratification and block randomization are included to ensure a balance of asthma severities between groups and an even number of participants per group. Outcome assessors will be blinded to participant group allocation.
Intervention (MCG participants)
Adherence to intervention by intervention and control groups
Intervention group n(%)
Control group n(%)
No. of reviews recommended by intervention pharmacist
No. of asthma action plans up taken
No. of recommended medication changes up taken
Control (UCG participants)
The control group will receive usual medical care; this normally includes their regular antenatal visits ranging from weekly to monthly depending on trimester and other complications. They will not receive the intervention, any additional monitoring or education sessions like participants in the MCG. If during follow ups at three and six months, their asthma control becomes a concern (2 or more documented exacerbations without resolution (i.e. increasing preventer dose) since prior assessment or their ACQ score exceeds 2, the participant and their family physician will be notified (with participant permission). This notification will be taken into account when we do the analysis.
Both groups will be given a summarised version of the “Asthma and Healthy Pregnancy” brochure from the Asthma Foundation of New South Wales, Australia which is a pamphlet on basic asthma facts to avoid unfair disadvantage to participants in the control group and to minimise the risks of poorly controlled asthma.
ACQ scores and asthma outcomes at Baseline, 3 and 6 months
At 3 months
At 6 months
Intervention group (n=30)
Control group (n=30)
Intervention group (n=30)
Control group (n=30)
Intervention group (n=30)
Control group (n=30)
No. of asthma related hospital visits
Days off work
No of days of asthma related oral corticosteroid use
Preventer to reliever ratio
ACQ scores, asthma-related hospital visits and days off work, oral corticosteroid use and preventer to reliever use ratios will be compared at three and six months between groups. Both groups will be assessed using the same data collection form at 3 and 6 months (once in their second trimester and once in their third trimester) and the results will be compared. The assessor collecting the data at three and six months in both groups will be different from the intervention pharmacist and will be blinded to participant group allocation. The assessor will not be given any clinical information about each participant and will be unaware of the study protocol (including details of the intervention) just in case a participant inadvertently discloses details to the assessor. Pregnancy and neonatal outcomes will be confirmed via medical records shortly after delivery.
Sample size calculation
This is a pilot study, however sample size was still calculated to guide recruitment. Using a conservative standard deviation of 0.66, to detect a change in ACQ score of 0.5 or more between groups, a sample size of 29 per arm would have 80% power with a two sided 5% significance level assuming the two variances are the same. To allow for 20% attrition, 35 participants will be recruited in each arm.
The primary analysis will be intention to treat. Per protocol analyses will also be conducted. The baseline characteristics of participants in the intervention and control groups will be compared using Chi-square, Student t-test or Mann–Whitney tests if distributional assumptions are not satisfied. ACQ scores at baseline, three and six months will be compared using Mann–Whitney test. Secondary outcomes will be listed as descriptive statistics and analysed using similar tests. FEV1/FEV6 trends will be described as these are observational data only. Sensitivity and predictive validity of the ACQ would also be investigated.
This trial has been approved by the Mercy Health Research Ethics Committee, The Royal Women’s Hospital Research Ethics Committee and Monash University Human Research Ethics Committee. The trial has also been registered with the Australian and New Zealand Clinical Trial Registry ACTRN12612000681853.
The proposed intervention has the potential to improve health outcomes in pregnant women with asthma, by reducing the incidence and severity of maternal exacerbations, and potentially reducing the perinatal morbidity associated with preterm birth and impaired fetal growth. These interventions have the potential to reduce health care costs through fewer asthma-related unplanned medical and emergency department visits for pregnant women. In addition, the costs associated with poor pregnancy and neonatal outcomes that can result from poorly controlled asthma i.e. pre-term births and low birth weight babies (parenteral nutrition costs, Neonatal Intensive Care admissions, assisted ventilation etc.) would be reduced. The interventions could also have a positive impact on the health of future generations. If the proposed intervention is successful and cost-effective, it may justify additional support services for pregnant women with chronic health conditions such as asthma. These support services could readily be made available and accessible in the community as well as hospital settings.
The trial is also the first to investigate the use of FEV1/FEV6 monitoring during pregnancy. This trial is powered to assess the primary asthma symptom-related endpoint, but not sufficient enough to draw conclusions in regards to maternal and perinatal outcomes. It has been expressed that it is difficult to distinguish between the shortness of breath associated with pregnancy and the airway obstruction associated with asthma . Observational findings from this trial could help examine patterns and trends of FEV1/FEV6 values. It is suggested that overweight individuals have a lower FEV1 and the expanding uterus during pregnancy may further reduce this by decreasing lung volumes . However, significant changes in FEV1 coupled with reduced FEV1/FEV6 ratios are likely to be due to deteriorating asthma control.
Moreover, as the lung function of a pregnant woman differs from that of a non-pregnant woman , a target range for FEV1/FEV6 measurements during pregnancy could be identified and prompt further research in using this ratio as a marker for asthma control during pregnancy. FEV1/FEV6 could be a simple and easier method of assessing asthma control and help prescribers better distinguish between asthma symptoms and the shortness of breath associated with pregnancy. Women will have the convenient option of monitoring their asthma at home using a handheld spirometer and adjusting therapy or management according to an individualised asthma action plan.
The MAMMA trial will investigate the role of participant self-monitoring and multidisciplinary team care in the management of asthma during pregnancy. The use of FEV1/FEV6 as a measure of lung function in pregnancy will also be explored. Empowering women to take control of this common chronic health condition and a multidisciplinary approach to management could potentially reduce the burden of asthma during pregnancy.
AL is a PhD student at Monash University and works as a pharmacist in Mercy Hospital for Women. She also works part-time in community pharmacy and for the Asthma Foundation of Victoria. Her research is based on optimizing the management of asthma during pregnancy.
KS is an Associate Professor in the Centre for Medicine Use and Safety at Monash University. Her research interests include medication adherence and asthma management.
MJA is Professor of Clinical Epidemiology at Monash University and a Visiting Medical Officer in Allergy, Immunology & Respiratory Medicine at the Alfred Hospital in Melbourne.
SW is a Professor of Maternal Fetal Medicine, University of Melbourne, and Director of Perinatal Medicine, Mercy Hospital for Women
JG is a Senior Lecturer in the Centre for Medicine Use and Safety at Monash University. His research targets improving asthma and chronic obstructive pulmonary disorder management, medication adherence, smoking cessation and medication use in pregnancy.
Asthma Control Questionnaire
Appearance, Pulse, Grimace, Activity, Respiratory
Forced Expiratory Volume in one second
Forced Expiratory Volume in six seconds
Multi-disciplinary Care Group
Usual Care Group.
The authors would like to thank the Asthma Foundation of Victoria for their endorsement and Paul Drinkwater, Swee Wong, Gordon Spalding, Lisa Wolke, Debra Pidd and Gabrielle Flemming for assistance in developing recruitment strategies for the project.
- Boyle EM, Poulsen G, Field DJ, Kurinczuk JJ, Wolke D, Alfirevic Z, Quigley MA: Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study. BMJ. 2012, 344: e896-10.1136/bmj.e896.PubMed CentralView ArticlePubMed
- Martel MJ, Rey E, Beauchesne MF, Malo JL, Perreault S, Forget A, Blais L: Control and severity of asthma during pregnancy are associated with asthma incidence in offspring: two-stage case–control study. Eur Respir J. 2009, 34: 579-587. 10.1183/09031936.00074608.View ArticlePubMed
- Levine RS, Hennekens CH, Jesse MJ: Blood pressure in prospective population based cohort of newborn and infant twins. BMJ. 1994, 308: 298-302. 10.1136/bmj.308.6924.298.PubMed CentralView ArticlePubMed
- Barker DJP: Fetal nutrition and cardiovascular disease in later life. Br Med Bull. 1997, 53: 96-108. 10.1093/oxfordjournals.bmb.a011609.View ArticlePubMed
- Rocklin RE: Asthma, asthma medications and their effects on maternal/fetal outcomes during pregnancy. Reprod Toxicol. 2011, 32: 189-197. 10.1016/j.reprotox.2011.05.023.View ArticlePubMed
- Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia J, Gibson PG: A meta-analysis of adverse perinatal outcomes in women with asthma. BJOG. 2011, 118: 1314-1323. 10.1111/j.1471-0528.2011.03055.x.View ArticlePubMed
- Schatz M, Harden K, Forsythe A, Chilingar L, Hoffman C, Sperling W, Zeiger RS: The course of asthma during pregnancy, post partum, and with successive pregnancies: a prospective analysis. J Allergy Clin Immunol. 1988, 81: 509-517. 10.1016/0091-6749(88)90187-X.View ArticlePubMed
- Kircher S, Schatz M, Long L: Variables affecting asthma course during pregnancy. Ann Allergy Asthma Immunol. 2002, 89: 463-466. 10.1016/S1081-1206(10)62082-0.View ArticlePubMed
- Lim AS, Stewart K, Abramson MJ, George J: Management of asthma in pregnant women by general practitioners: a cross sectional survey. BMC Fam Pract. 2011, 12: 121-10.1186/1471-2296-12-121.PubMed CentralView ArticlePubMed
- Lim A, Stewart K, Konig K, George J: Systematic review of the safety of regular preventive asthma medications during pregnancy. Ann Pharmacother. 2011, 45: 931-945. 10.1345/aph.1P764.View ArticlePubMed
- Ernst P, Suissa S: Systemic effects of inhaled corticosteroids. Curr Opin Pulm Med. 2012, 18: 85-89. 10.1097/MCP.0b013e32834dc51a.View ArticlePubMed
- Del-Rio-Navarro B, Berber A, Blandon-Vijil V, Ramirez-Aguilar M, Romieu I, Ramirez-Chanona N, Heras-Acevedo S, Serrano-Sierra A, Barraza-Villareal A, Baeza-Bacab M, Sienra-Monge JJ: Identification of asthma risk factors in Mexico City in an International Study of Asthma and Allergy in Childhood survey. Allergy Asthma Proc. 2006, 27: 325-333. 10.2500/aap.2006.27.2874.View ArticlePubMed
- Meyer NL, Addis IB, Lipscomb GH: Ureteral avulsion during uterine dilatation and evacuation: a case report. J Reprod Med. 2006, 51: 581-583.PubMed
- MacMullen NJ, Tymkow C, Shen JJ: Adverse maternal outcomes in women with asthma: differences by race. MCN Am J Matern Child Nurs. 2006, 31: 263-268.View ArticlePubMed
- Shapiro JM: Critical care of the obstetric patient. J Intensive Care Med. 2006, 21: 278-286. 10.1177/0885066606290390.View ArticlePubMed
- Dombrowski MP: Asthma and pregnancy. Obstet Gynecol. 2006, 108: 667-681. 10.1097/01.AOG.0000235059.84188.9c.View ArticlePubMed
- Rahimi R, Nikfar S, Abdollahi M: Meta-analysis finds use of inhaled corticosteroids during pregnancy safe: a systematic meta-analysis review. Hum Exp Toxicol. 2006, 25: 447-452. 10.1191/0960327106het647oa.View ArticlePubMed
- Ohta K, Yamaguchi M, Akiyama K, Adachi M, Ichinose M, Takahashi K, Nishimuta T, Morikawa A, Nishima S: Japanese guideline for adult asthma. Allergol Int. 2011, 60: 115-145. 10.2332/allergolint.11-RAI-0327.View ArticlePubMed
- Holcomb SS: Asthma update 2005: guidelines for pregnant women. Dimens Crit Care Nurs. 2005, 24: 263-266. 10.1097/00003465-200511000-00003.View ArticlePubMed
- Chambers K: Asthma education and outcomes for women of childbearing age. Case Manager. 2003, 14: 58-61.View ArticlePubMed
- Sawicki E, Stewart K, Wong S, Leung L, Paul E, George J: Medication use for chronic health conditions by pregnant women attending an Australian maternity hospital. Aust N Z J Obstet Gynaecol. 2011, 51: 333-338. 10.1111/j.1479-828X.2011.01312.x.View ArticlePubMed
- Lim AS, Stewart K, Abramson MJ, Ryan K, George J: Asthma during pregnancy: the experiences, concerns and views of pregnant women with asthma. J Asthma. 2012, 49: 474-479. 10.3109/02770903.2012.678024.View ArticlePubMed
- Powell H, McCaffery K, Murphy VE, Hensley MJ, Clifton VL, Giles W, Gibson PG: Psychosocial outcomes are related to asthma control and quality of life in pregnant women with asthma. J Asthma. 2011, 48: 1032-1040. 10.3109/02770903.2011.631239.View ArticlePubMed
- McCallister JW, Benninger CG, Frey HA, Phillips GS, Mastronarde JG: Pregnancy related treatment disparities of acute asthma exacerbations in the emergency department. Respir Med. 2011, 105: 1434-1440. 10.1016/j.rmed.2011.05.015.View ArticlePubMed
- British Thoracic Society: Asthma in pregnancy. British guidelines on the management of asthma. 2009, Edinburgh: Scottish Intercollegiate Guideline Networks, 71-72.
- Powell H, Murphy VE, Taylor DR, Hensley MJ, McCaffery K, Giles W, Clifton VL, Gibson PG: Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet. 2011, 378: 983-990. 10.1016/S0140-6736(11)60971-9.View ArticlePubMed
- Jing J, Huang T, Cui W, Xu F, H-h S: Should FEV1/FEV6 Replace FEV1/FVC Ratio To Detect Airway Obstruction?. Chest. 2009, 135: 991-998. 10.1378/chest.08-0723.View ArticlePubMed
- National Asthma Council of Australia: Diagnosis and Classification in Adults. Asthma Management Handbook 2006. 2006, Melbourne: National Asthma Council Ltd, 78-
- Juniper E, O’Byrne P, Guyatt G, Ferrie P, King D: Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999, 14: 902-907. 10.1034/j.1399-3003.1999.14d29.x.View ArticlePubMed
- Grindheim G, Toska K, Estensen ME, Rosseland LA: Changes in pulmonary function during pregnancy: a longitudinal cohort study. BJOG. 2012, 119: 94-101. 10.1111/j.1471-0528.2011.03158.x.View ArticlePubMed
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/12/1094/prepub
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