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Table 4 Constrained model fits to the human influenza infection data in Figure 6.

From: Exploring the effect of biological delays in kinetic models of influenza within a host or cell culture

A/Texas/36/91 (H1N1) [38]

Dista

c (h–1)

p b,c

Ï„ L (h)

σ L

Ï„ I (h)

σ I

(h)

(h)

R 0

SSRd

exp

0.19

0.022

280

5.4

—

16.9

—

3.7

11.7

89

1.00

δ

0.059

2.85

62

10.2

—

23.0

—

10.2

23.0

390

1.00

N

0.059

0.013

100

1.8

(4.6 h)c

12.1

(9.7 h)

3.9

13.4

240

0.98

lnN

0.059

0.72

99

8.7

(0.49)

14.5

(0)

8.7

14.5

250

1.00

A/Bethesda/1/85 (H3N2) [39]

Dist

c (h–1)

V 0

p

Ï„ L (h)

σ L

Ï„ I (h)

σ I

(h)

(h)

R 0

SSR

exp

0.11

7.0

1.3 × 105

9.0

—

2.2

—

6.4

1.5

20

0.91

δ

0.10

28.4

7.7 × 103

9.9

—

31.5

—

9.9

31.5

320

0.88

N

0.10

10.6

1.2 × 104

9.6

(4.6 h)

19.9

(9.7 h)

9.7

20.1

200

0.90

lnN

0.10

11.8

8.0 × 103

8.5

(0.49)

30.4

(0)

8.5

30.4

300

0.91

  1. a — Delay model used: exponential (exp), fixed (δ), normal (N), and lognormal (lnN).
  2. b — Units of p are [V]·h–1, where [V] = TCID50/mL, the units of viral titer.
  3. c — The value of pβ was held fixed at 1 h–2 for all fits; values in parentheses were also eld fixed.
  4. d — SSR′ is the ratio of the SSR to that of the empirical fit.