Missing and accounted for: gaps and areas of wealth in the public health review literature
© Tirilis et al; licensee BioMed Central Ltd. 2011
Received: 19 May 2011
Accepted: 3 October 2011
Published: 3 October 2011
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© Tirilis et al; licensee BioMed Central Ltd. 2011
Received: 19 May 2011
Accepted: 3 October 2011
Published: 3 October 2011
High-quality review evidence is useful for informing and influencing public health policy and practice decisions. However, certain topic areas lack representation in terms of the quantity and quality of review literature available. The objectives of this paper are to identify the quantity, as well as quality, of review-level evidence available on the effectiveness of public health interventions for public health decision makers.
Searches conducted on http://www.health-evidence.ca produced an inventory of public health review literature in 21 topic areas. Gaps and areas of wealth in the review literature, as well as the proportion of reviews rated methodologically strong, moderate, or weak were identified. The top 10 topic areas of interest for registered users and visitors of http://www.health-evidence.ca were extracted from user profile data and Google Analytics.
Registered users' top three interests included: 1) healthy communities, 2) chronic diseases, and 3) nutrition. The top three preferences for visitors included: 1) chronic diseases, 2) physical activity, and 3) addiction/substance use. All of the topic areas with many (301+) available reviews were of interest to registered users and/or visitors (mental health, physical activity, addiction/substance use, adolescent health, child health, nutrition, adult health, and chronic diseases). Conversely, the majority of registered users and/or visitors did not have preference for topic areas with few (≤ 150) available reviews (food safety and inspection, dental health, environmental health) with the exception of social determinants of health and healthy communities. Across registered users' and visitors' topic areas of preference, 80.2% of the reviews were of well-done methodological quality, with 43.5% of reviews having a strong quality rating and 36.7% a moderate review quality rating.
In topic areas in which many reviews are available, higher level syntheses are needed to guide policy and practice. For other topic areas with few reviews, it is necessary to determine whether primary study evidence exists, or is needed, so that reviews can be conducted in the future. Considering that less than half of the reviews available on http://www.health-evidence.ca are of strong methodological quality, the quality of the review-level evidence needs to improve across the range of public health topic areas.
A systematic review consists of an examination of all of the primary studies on a topic, which includes searching for, collating, and assessing the studies, to establish conclusive evidence about a topic . The Cochrane Collaboration is an international body that produces systematic reviews of primary research at the highest standard, and as such, this is a commonly accepted definition of systematic reviews. Evidence-informed public health advocates the incorporation of the best available scientific evidence into decision making . Review level evidence is an important part of evidence-informed public health decision making, since reviews synthesize the results of individual studies, providing a more accurate estimate of the effects of an intervention . Rigorous synthesis of primary research minimizes bias [4–6], explains differences among studies relating to the same research question [7, 8], and presents more precise and consistent summary statistics than the effect sizes found in individual studies [5, 8–10]. Well-conducted reviews provide high-quality, accurate evidence [4–6], increasing decision-makers' confidence in the strength of the review evidence and in applying the findings in practice . Public health decision makers prefer using systematic reviews to assist in decision-making given that review level evidence saves time and is more efficient compared to using primary studies [6, 11]. Systematic review findings can be generalized to a larger sample, providing a great evidence base for users; such external validity is essential to ensure adaptability and applicability of evidence-based interventions into the local context . Consequently, systematic reviews are useful for informing and influencing public health policy and practice decisions [7, 13, 14].
While the value of review level evidence is acknowledged and well documented, public health decision makers encounter a number of challenges in incorporating systematic reviews in their decision making.
Review level evidence is available in journals and obtainable through bibliographic database searches , yet barriers still exist in accessing the information. Public health decision-makers often have difficulties locating systematic reviews in the published literature due to database indexing limitations, limited availability of relevant public health reviews, lack of primary study evidence and thus a lack of reviews in some topic areas, and a lack of interest in certain topic areas by researchers conducting reviews [3, 15, 16].
Even when systematic reviews are identified, only a small proportion of those are relevant to public health. For example, one search strategy captured 41, 871 abstract titles across all research topics in public health but once screened, only 1, 356 were identified as being potentially relevant, of which only 207 reviews were actually deemed relevant to public health . The majority of published systematic reviews pertain to clinical topics rather than public health . Consequently, there are gaps at the systematic review level across the spectrum of public health practice [6, 17].
When relevant reviews are located, users still need to be critical of that evidence. There are a number of search engines that provide evidence from various databases, such as the Cochrane Database of Systematic Reviews, PubMed, and the Campbell Collaboration, but the evidence is not critically appraised [17, 18]. While some of these databases which include public health relevant evidence assess the quality of the evidence, many do not . To reduce bias in evidence-informed practice, public health decision makers need to be able to assess the methodological quality of systematic reviews . However, critical appraisal skills have been identified as a significant barrier to using research evidence in decision making . Development of individual capacity is important in addressing appraisal challenges as well as providing support .
Health Evidence is a research and service organization aimed at supporting Canada's public health decision makers in accessing and interpreting research evidence. The target audience for Health Evidence includes medical officers of health, policy makers, program managers, and frontline workers in public health. Given the audience, decision making may take place at the local level (such as public health units/regional health authorities), provincial level (such as ministries), or federal level (such as government). Our most widely accessible resource is the http://www.health-evidence.ca online registry of systematic reviews; a free, user-friendly, searchable database of public health relevant, quality-appraised systematic reviews published since 1985 evaluating the effectiveness of public health interventions. Given that unpublished literature, such as conference abstracts, provide little added value , Health Evidence mainly focuses on published review literature. In order to identify the scope of interventions to include in the health-evidence.ca registry, qualitative interviews were conducted, as well as seeking organizational charts and information from every province and territory in Canada on the services public health units provide. Systematic reviews are considered relevant if: 1) the article is a review, which includes the synthesis of more than one primary study; 2) the intervention is relevant to public health practice; 3) the effectiveness of an intervention is evaluated; 4) the evidence on health outcomes is reported; and 5) the search strategy is described . To assess the methodological quality, the following ten criteria are used: 1) a clearly focused question was stated; 2) inclusion criteria were explicitly stated; 3) a comprehensive search strategy was described; 4) an adequate number of years were covered in the search; 5) a description of the level of evidence was provided; 6) the methodological rigor of primary studies was conducted and results were described; 7) the methodological quality of primary studies was assessed by two reviewers and the level of agreement was provided; 8) tests of homogeneity or assessment of similarity of results across studies was conducted and reported; 9) appropriate weighting of primary studies was conducted; and 10) the author's interpretation of the results were supported by the data . Each criterion is equally weighted and a final methodological score is tallied out of 10. Reviews with an overall rating of eight or more are considered strong, five to seven, moderate, and below four are considered to be weak in methodological quality.
Due to competing demands, it is necessary for decision makers to quickly find, assess and use evidence to inform their decision making. The health-evidence.ca registry eliminates the need for users to search individual databases, identify relevant reviews, and conduct critical appraisal on the effectiveness of public health interventions. The tools used by Health Evidence to assess relevance and conduct critical appraisal are available online http://health-evidence.ca/html/HowJudgeforYourself, accessed 6 May 2011), and users can view completed critical appraisal tools for each review in the registry.
In order to reach public health decision makers, Health Evidence is promoted at conferences, workshops, and site-visits, through outreach and engagement, networking, and listservs via website posts and e-newsletters, and through social media, such as Twitter and YouTube. Health Evidence also connects with public health decision makers through various partnerships and collaborations with the National Collaboration Centres for Public Health, public health units, the Canadian Best Practices Portal, and the Public Health Agency of Canada. The registry is also listed as a resource on several public health organization and university websites, such as Research into Action, Pan American Health Organization, KT+ Knowledge Translation, Canadian Institute for Health Research (CIHR) Knowledge Translation and Commercialization, Nova Southeastern University, Dalhousie University, and more.
Health-evidence.ca has nearly 5, 000 registered users, and sees over 40, 000 visitors annually representing more than 150 countries. In the development of the health-evidence.ca registry, 21 topic areas of interest to public health decision makers were identified through focus groups and consultations with key informants within the public health setting. The purpose of the registry is to facilitate access to review-level evidence for decision makers working in program planning and policymaking in public health and health promotion . All reviews in the registry are indexed according to these 21 Focus of Review topic areas allowing site visitors to search the registry using common public health terms. In addition, each registered user completes a profile when signing up to the site checking off as many of the 21 topic areas relevant to them. This enables each registered user to receive a list of reviews related to their areas of interest, along with a rating of the methodological quality of each review, each quarter when the registry is updated.
Unfortunately, for some public health topics, there are limited or no high quality reviews available and for others the reviews that are available are not of good methodological quality, meaning that use of these findings in decision making requires careful consideration. A thorough search of http://www.health-evidence.ca allowed us to indentify the top areas of interest to public health decision makers, and provide an overview of the availability of review-level evidence within these areas. In this paper we will not only identify topic areas of high interest to public health decision makers, we will also highlight existing gaps as well as identify topic areas with an abundance of high-quality evidence. One objective of this paper is to identify the quantity of systematic reviews available on the effectiveness of public health interventions, so as to encourage researchers and research funders to conduct/fund systematic reviews where gaps exist. A second objective is to identify the quality of systematic review evidence on the effectiveness of public health interventions in order to encourage higher quality methodological reviews and higher level synthesis of topics areas rich in high-quality reviews (e.g., review of reviews).
The health-evidence.ca registry of systematic reviews is populated through an extensive ongoing search (1985-present) of seven electronic databases (MEDLINE, EMBASE, CINAHL, PsycINFO, Sociological Abstracts, BIOSIS, SportDiscus), handsearching of 46 journals, and screening the reference lists of all relevant reviews . Reviews are assessed for relevance, and then relevant reviews are indexed by commonly-used public health terms and quality assessed by two independent reviewers who come to agreement on the final rating of each review (strong, moderate, weak). More detail on http://www.health-evidence.ca has previously been published .
Registered user areas of interest were assessed by querying the health-evidence.ca registered user database and looking at the areas of interest identified by all users who registered up to December 31, 2010. Data were aggregated by topic area. Registered user data is provided voluntarily by users and aggregation ensures individual data remain anonymous. Topic areas of interest were ranked from highest to lowest rates of user interest. The top 10 areas of interest were summed to generate the denominator: total user interest in the top 10 topic areas.
Visitor areas of interest were assessed by summing frequency of visitor searches of the 21 Focus of Review topic areas and visitor use of the topic area browse menu for the period January 1, 2010 to December 31, 2010. Visitor site usage is tracked via Google Analytics, a web analytics tool that collects and aggregates non-personal data to report on visitor interaction with the health-evidence.ca website. Total search and browse access by unique visitors were ranked from highest to lowest pageviews. The top 10 areas of interest were summed to generate the denominator: total visitor interest in the top 10 topic areas.
The health-evidence.ca registry was used to identify gaps and areas of wealth in the public health review literature. Each of the 21 Focus of Review topic areas were searched, and the quantity and proportion of reviews rated methodologically strong, moderate, and weak were identified. Three categories were used to define availability of reviews within each topic area: (+) few, representing 1-150 reviews; (++) moderate, representing 151-300 reviews; and, (+++) many, representing topic areas possessing greater than 301 reviews. Reviews that addressed multiple topics were accounted for within each topic area that they addressed (e.g., a review on the effectiveness of exercise in preventing chronic disease would be categorized as both physical activity and chronic disease).
Overview of registered user's and visitors' top 10 preferred topic areas and the availability of review evidence by methodological quality
Reg. Users' Top 10
Visitors' Top 10
Main Topic Areas
Social Determinants of Health
While there was overlap between six of the registered users' and visitors' top areas of interest, the topic areas healthy communities, adult health, adolescent health, and, communicable disease/infection were preferred by registered users alone, and visitors had preferences for addiction/substance use, parenting, injury prevention/safety, and, reproductive health.
For the six areas of interest similar to both registered users and visitors, differences exist in the order of expressed interest. Three topic areas ranked similarly among the top 10 for both registered users and visitors with a difference of only one rank apart: chronic disease ranked high on both top 10 lists, ranking first for visitors and second for registered users; nutrition ranked third for registered users and fourth for visitors; and social determinants of health ranked sixth for visitors and seventh for registered users. The remaining three topic areas that both visitors and registered users were interested in included: mental health, ranking seventh for visitors and ninth for registered users; physical activity, ranking second for visitors and fifth for registered users, and, child health, ranking fourth for registered users and ninth for visitors. In the top five highest ranking common topic areas, both groups had interest in chronic diseases, nutrition, and, physical activity
Characteristics of registered users and visitors from January 1 to December 31, 2010
Registered Users (4, 668)
Visitors (40, 166)
90.6% (4, 229)
75.0% (30, 107)
82.7% (3, 859)
65.0% (26, 113)
4.6% (1, 841)
4.6% (1, 853)
41.9% (16, 810)
6.0% (2, 408)
Prince Edward Island
Newfoundland & Labrador
Not specified (within Canada)
United States of America
9.9% (3, 994)
14.4% (5, 774)
4.0% (1, 604)
3.9% (1, 570)
South America, Central America, Caribbean
Language Preference §
98.1% (4, 580)
83.3% (33, 459)
6.2% (2, 482)
3.6% (1, 463)
3.4% (1, 370)
Public Health/Health Services
54.6% (2, 547)
15.8% (5, 502)
18.3% (6, 393)
6.7% (2, 340)
53.0% (18, 503)†
4.0% (1, 408)
Comparison of the top ten priority topic areas by registered users and visitors and the availability of reviews
Main Topic Areas
Food Safety & Inspection
Sexually Transmitted Infections
Social Determinants of Health
Topic areas with fewer than 150 reviews included: food safety and inspection (13), dental health (62), social determinants of health (66), environmental health (69), and healthy communities (134). Of the areas with fewer than 150 reviews, healthy communities ranked first as an area of interest for registered users with 2, 548 registered users indicating interest in this topic. Social determinants of health ranked sixth and seventh for visitors and registered users respectively, with 1, 528 visitor searches submitted in 2010 and 1, 734 registered users indicating interest in the topic. The majority of health-evidence.ca registered users did not have preference for the other three identified areas with fewer than 150 reviews.
Topic areas with a moderate number of reviews (151-300 reviews) included: infant health (153), senior health (152), sexual health (195), sexually transmitted infections (208), communicable disease/infection (229), reproductive health (232), parenting (282), and, injury prevention/safety (241). Four of these eight topic areas have expressed interest by visitors or registered users. For visitors, ranking at fifth, eighth and tenth place respectively, searches submitted in 2010 for parenting totalled 1, 813 pageviews, for injury prevention/safety 1, 360, and, for reproductive health 1, 273 pageviews. Ranking tenth place, 1, 422 registered users indicated interest in the topic communicable disease/infection.
Topic areas with a large quantity of systematic reviews (301 or more reviews) include: mental health (336), physical activity (353), addiction/substance use (355), adolescent health (367), child health (409), nutrition (426), adult health (552), and chronic diseases (702). All of the topic areas with many available reviews (301+) were of interest to registered users and/or visitors. Chronic diseases, nutrition, and, physical activity were the three highest-ranking areas of interest common across both groups. The number one visitor area of interest and number two registered user area of interest was chronic diseases with 3, 115 visitor searches submitted in 2010, and 2, 153 registered users expressing interest in the topic. Nutrition ranked third for registered users and fourth for visitors with 1, 877 user interests, and 2, 010 visitor searches respectively. Physical activity ranked second for visitors with 2, 350 searches, and fifth for registered users with 1, 824 interested in the topic. Child health and mental health were two additional topics with many available reviews that rank in the top ten for both registered users and visitors. In the area of child health, 1, 846 registered users expressed interest and 1, 293 visitors submitted searches, ranking it fourth and ninth respectively, and the area of mental health ranked seventh for visitors with 1, 502 searches submitted, and ninth for registered users with 1, 459 interested in the topic. The remaining three topic areas with many available reviews were preferred by either visitors or registered users (i.e., not common to both groups). Addiction/substance use ranked third for visitors with 2, 283 search page views in 2010. Adult health and adolescent health ranked sixth and eighth respectively for registered users with 1, 778 and 1, 636 registered users indicating interest in each of these topics.
A master list categorizing all of the 21 topic areas and the corresponding number of reviews available on the effectiveness of public health interventions, as well as the methodological quality, are listed in the additional file 1.
Overview of sub-topic areas with no review evidence (N = 34)
Female genital mutilation
Hormone replacement therapy
Food borne diseases
Hand foot mouth disease
Sexually transmitted infections
Toxic shock syndrome
Carbon monoxide poisoning
Food Safety & Inspection
Bovine spongiform encephalopathy
Food processing & inspection
Overview of sub-topic areas with less than 5 reviews available (N = 68)
Blood borne diseases
West nile virus
ETS (environmental tobacco smoke)
Food Safety & Inspection
Food borne outbreaks
Food premise inspection
Food processing & inspection
Food service inspection
Community health centers
Borderline personality disorder
Fetal alcohol syndrome
Social Determinants of Health
Overview of sub-topic areas with greater than 25 reviews available (N = 71)
Community health services
Fruit OR vegetables
Maternal child health
Sexually Transmitted Infections
Social Determinants of Health
Income and Social Status
The Health Evidence methodological quality rating is based on the ten criteria used to assess the strength of the methods. The proportion of reviews rated as having strong, moderate, or weak methodological quality was constant across all topic areas. 80.2% of the reviews on health-evidence.ca were of strong (43.5%) or moderate (36.7%) methodological quality. These well-done reviews included slightly more strong review quality ratings compared to the moderate review ratings. The remaining 19.8% of reviews in the top areas of interest were of weak methodological quality. These weak quality reviews met four or fewer methodological quality criteria, and as such, scored poorly on six or more of the ten criteria. Based on the weak reviews, 10.5% did not have a clearly focused question, 46.5% did not use appropriate inclusion criteria, 87.7% did not have a comprehensive search strategy, 34% did not cover an adequate number of years, 48% did not describe the level of evidence in the primary studies, 96.6% did not assess the methodological quality of the primary studies, 97% did not have transparent results, 53.9% did not appropriately combine the findings of the results across studies, 92.9% did not use appropriate methods to combine or compare results across studies, and 82.4% did not have data to support the author's interpretations.
A number of sub-topic areas within public health featured no reviews or a very small number of reviews including those within the main topic areas for women's health (sub-topics include female genital mutilation, hormone replacement therapy, and infertility as examples); communicable disease/infection (sub-topics include food-borne diseases, hantavirus, and Norwalk, among others); food safety and inspection (sub-topics include botulism, food processing and inspection, and Hepatitis A as examples); dental health (sub-topic: dental implants); environmental health (sub-topics include asbestos, carbon monoxide poisoning, environmental epidemiology, extreme temperature, swimming pools, and flood, as examples). In these areas, review literature is needed to add to the existing body of literature from which decision makers can draw. In topic areas lacking in review literature, realist reviews, which provide explanatory analyses , are a relatively new type of review that may provide further insight into the topic area.
While these areas show the deficits in review literature, in 25 other sub-topic areas there was a wealth of systematic review literature of moderate or strong quality, including but not limited to, alcohol abuse/use, smoking cessation, women's health, cancer, cardiovascular disease, lifestyle behaviours, disease transmission, depression, diet, healthy weight, exercise, and HIV. In these areas offering many reviews, most had 15 or more which were of strong methodological quality. While review groups can identify and fill gaps in areas where evidence is lacking, there is also an opportunity to produce higher level syntheses where good-quality review evidence is available. Based on this analysis of the published, public health review literature catalogued in http://www.health-evidence.ca, all of the topic areas having many available reviews were also preferred areas of interest for users of the site. It is unclear how the availability of evidence is linked to interest in a topic, but it may be that demand can generate reviews in a particular topic area and that the public spurs research to fill gaps . Alternately, preference for a topic may be a reflection of there being available evidence that drives interest in the topic and web site updates regarding that topic. Interestingly, the 15 priority topic areas indicated by a 2005 Cochrane global priority setting exercise  still closely match the top 10 topic areas of interest indicated by health-evidence.ca users and visitors.
While resources such as http://www.health-evidence.ca, provide synthesized, high quality research evidence relevant to public health practice, coverage of health topics is not equal . Compared to clinical review literature, there is far less population health systematic review literature  and within public health, a number of topic areas are without a solid base of review evidence evaluating the effectiveness of interventions (e.g., environmental health, social determinants of health) [18, 26, 27]. Public health studies are difficult to design and results are drawn from natural experiments (e.g. one health unit adopting a program compared to another health unit), thus fewer studies have been developed on the effectiveness of public health interventions compared to randomized controlled trials on medical treatments [28, 29]. However this lack of review-level evidence doesn't necessarily indicate a lack of evidence . There may be primary research or other forms of evidence that can inform decisions but which may not yet have been synthesized. In cases where there are no eligible studies available to be reviewed for a particular topic, the result can be an "empty review", meaning that no studies were located which met the inclusion criteria to answer the question for review. Empty reviews can go unreported but may in fact be useful since empty reviews indicate interest in an area, highlight gaps, and offer a snapshot of the state of research evidence at the time of publication . Even in light of a lack of evidence, or poor reporting of the evidence, decision makers can and should take an informed approach to having insufficient evidence .
An informed approach may be needed in topic areas that demonstrated a lack of review-level evidence, such as dental health, environmental health, food safety and inspection, and seniors' health, and particularly for public health priority areas such as healthy communities and social determinants of health. Consequently, the best literature may be sparse or of low quality in these particular topic areas. In these areas, new systematic review literature is needed to inform practice and policy decision making. It is unclear at this time whether gaps pertain only to reviews lacking in these topic areas, or whether there is a corresponding lack of primary studies as well, hindering the production of reviews. In some instances it may be necessary to first develop the primary study base in order for studies to be available for synthesis in a systematic review. Future reviews should be conducted on these broad topic areas for which review-level evidence on the effectiveness of interventions is lacking. Funding organizations should generate calls for syntheses to address these gap areas, while non-government and public health organizations should provide feedback on the lack of evidence in areas of interest to them to potential funders. Funding priorities for syntheses should reflect those areas which are priorities for public health decision makers both in Canada and internationally.
There are promising indicators of demand for reviews, including actions being taken to promote the use of reviews [6, 11, 19, 30, 32–36], an awareness of sites providing access to review-level evidence  and an increasing number of groups generating summaries of reviews . Despite this heightened activity, given the gaps, a greater investment is needed to provide an evidence base that can meet demand and determine how to apply existing good quality systematic reviews in different contexts . Organizations involved in the conduct of systematic reviews should direct synthesis funding to areas lacking in review content, or should consider higher-level reviews of reviews (where appropriate), where large bodies of review evidence already exist. Examples of organizations that conduct systematic reviews and reviews of reviews include: The Cochrane Database of Systematic Reviews http://www.cochrane.org/reviews/index.htm, The Campbell Collaboration http://www.campbellcollaboration.org, The Centre for Reviews and Dissemination (CRD) http://www.york.ac.uk/inst/crd/index_databases.htm, Health Technology Assessment international (HTAi) http://www.htai.org/, Effective Public Health Practice Project (EPHPP) http://www.ephpp.ca, CDC Guide to Community Preventative Services http://www.thecommunityguide.org, Canadian Agency for Drugs and Technology in Health (CADTH) http://www.cadth.ca/, Agency of Healthcare Research and Quality (AHRQ) http://www.ahrq.gov/ and the National Institute for Health and Clinical Excellence (NICE) http://www.nice.org.uk. Some groups have a prioritization process to identify and meet needs for systematic reviews; for example, the Agency of Healthcare Research and Quality has a topic prioritization group to determine the relative importance of their effectiveness reviews against a standard set of criteria to prioritize unmet needs . The Cochrane Collaboration aims to increase the quantity and quality of public health systematic reviews specifically , with the new Health Promotion and Public Health Review Group announced in 2006 to prioritize and produce public health relevant reviews . Authors have suggested that a global registry of anticipated public health studies could help to fill the gaps by making it easier to identify relevant, but potentially unpublished, primary studies available for review .
While well-done reviews in a large number of areas are available, it is important to continue to improve the quality of the overall body of public health review literature. Considering that the majority of weak reviews scored poorly on assessing the methodological quality of the primary studies, transparency, methods for combining or comparing results, conducting a comprehensive search strategy, and data supporting the author's interpretations, review authors should be cognisant of these criteria when conducting systematic reviews. In improving the quality of systematic reviews, the overall goals should ensure there are high quality reviews in all public health topic areas and a higher standard across the board.
Although this paper provides information on the quantity and quality of systematic reviews on the effectiveness of public health interventions, there are a few limitations, including the lack of information regarding visitors to the Health Evidence registry. While the majority of visitors access the registry from various internet service providers, we are unable to determine their organization and the relevance of the registry content to a particular organization. Additionally, it is unclear at this time whether visitors and registered users are using reviews housed in the registry to inform their practice decisions. Studies are ongoing to evaluate the registry's usefulness and effectiveness.
The result of this analysis demonstrates significant variation in the availability of review evidence across the 21 public health topic areas. For some topic areas, many reviews are available and a higher level synthesis is needed in order to provide decision makers with greater clarity to guide policy and practice for addiction/substance use, adolescent health, child health, chronic diseases, mental health, nutrition, and physical activity. At the other extreme however, there are topic areas for which there are few reviews to guide practice. Specifically, social determinants of health and healthy communities were identified as areas of interest that are lacking in review evidence. In these situations, an assessment is required to determine whether primary study evidence exists to contribute to reviews, or whether the primary studies are needed so that reviews can be conducted at some point in the future. Although there are gaps in the review literature on the effectiveness of public health interventions, just under half of the reviews available on health-evidence.ca are of strong methodological quality, demonstrating that good quality review level literature on which to base many public health programs and policies exists. It is hoped that the results of this analysis will provide direction to funders of reviews and organizations involved in conducting systematic reviews as to priority topic areas for consideration.
The authors gratefully acknowledge the support provided by the National Collaborating Centre for Methods and Tools (NCCMT) which resulted in this paper.
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