From: Cost-effectiveness of rotavirus vaccination in the Netherlands; the results of a consensus model
Description | Base case value | Distribution | References |
---|---|---|---|
Vaccine Efficacy | Â | Â | Â |
   Severe infections hospitalisation (first year) | 0.945 | Lognormal mean 0.945 (SE 0.014) | [21] |
   Waning rate per year (exponential decrease) | 0 | NA | [23] |
   Mild infections requiring an office visit (average first 2 years, see Methods) | 0.874 | Lognormal mean 0.874 (SE 0.052) | [24] |
   Waning rate per year (exponential decrease) | 0.09 | NA | Assumption |
   Mild infections treated at home (first year) | 0.720 | Lognormal mean 0.720 (SE 0.040) | [21] |
   Waning rate per year (exponential decrease) | 0.18 | NA | [21] |
Incidence per million children (<5 years) | Â | Â | Â |
   Total number of community-acquired RV cases | 65,680 | Normalised mean: 65,680 (90%CI; 43,890-90,945)a | [9] |
   No medical help requested | 52,947 | Total number of cases minus total number of GP visits (calculated) |  |
   GP visits | 12,733 | Normalised mean: 12,733 (90%CI; 6,922-20,384)a | [9] |
   Total hospitalisations | 3600 | Pert (2600; 3600; 4500) | [9] |
   Of which nosocomial infections | 13% | NA | [16] |
   Deaths as% of total number of hospitalisations | 0.02% | Triangular (0%; 0.02%; 0.12%) | [18] |
Total QALY detriment | Â | Â | Â |
   Rotavirus infection treated at home |  |  | |
   0-18 months | 0.0015 | See Methods section |  |
   18-59 months | 0.0025 |  |  |
   Rotavirus infection requiring medical attention (GP) |  |  | |
   0-18 months | 0.0022 |  |  |
   18-59 months | 0.0031 | See Methods section |  |
   Rotavirus infection requiring hospitalisation (including nosocomial) |  |  | |
   0-18 months | 0.0036 | See Methods section |  |
   18-59 months | 0.0042 |  |  |
Total direct costs per case | Â | Â | Â |
   Case treated at home (0-3 years)b | 4.25 | Triangular (2.66; 4.25; 7.44) | [7] |
   Case requiring GP visitb | 70.08 | Triangular (52.08; 70.08; 82.70) | |
   Case requiring hospitalisation | 2146 | Triangular (1933; 2146; 2359) | |
   Case requiring hospitalisation (nosocomial) | 1825 | Triangular (1280; 1825; 2377) | [7] |
Total indirect cost per case (care giver taking care of child) | Â | Â | Â |
   Case treated at home | 35.26 | Triangular (31.74; 35.26; 38.79) | |
   Case requiring GP visit | 51.09 | Triangular (45.99; 51.09; 59.20) | |
   Case requiring hospitalisationc | 55.41 | Triangular (49.87; 55.41; 60.95) | |
   Case requiring hospitalisation (nosocomial) | 45.34 | Triangular (40.80; 45.34; 49.87) | |
   Total cost per vaccinee | 50, 75, 100 | Triangular (50; 75; 100) | Assumption |