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Table 1 Classification of eligible studies by design, target population, outcomes and quality score (1990-2009)

From: Reduction of diabetes risk in routine clinical practice: are physical activity and nutrition interventions feasible and are the outcomes from reference trials replicable? A systematic review and meta-analysis

Author, year, reference #

Study Design

Total sample size

Target age group

Country & Setting of recruitment

Inclusion criteria: Normal or abnormal GT

Loss to follow-up rate %

Outcome assessment:

Measured OR

self-reported

Study Quality score1

*Barclay, 2008 [87]

RCT

37

50-85

UK: Single general practice

IGT or IFG

19%

Measured weight, WC, FPG, lipids, self-reported exercise, 4-day food diary

7

Greaves, 2008 [86]

RCT

141

18+

UK: 2 GP surgeries

NGT or IGT

18%

Measured weight, WC and self-reported physical activity

7

*Bo, 2007 [48]

RCT

375

45-64

Italy: Family physician GPs

Metabolic Syndrome

11%

Self-reported FFQ & exercise; Measured FPG, insulin, weight, WC, lipids, CRP

8

*Kosaka, 2005 [49]

RCT

458

Adult males 30+

Japan: Hospital outpatient Clinic

IGT

15.9%

Measured FPG, OGTT, HbA1c, measured weight, lipids

7

Torgerson, 2004 [80]

RCT

3,304

30-60

Sweden: Medical

centres

NGT & IGT

57% overall; 48% on medication & 66% on placebo

Measured weight, WC,

FPG, lipids, serum insulin, fibrinogen

7

*Dyson, 1997 [50]

RCT

227

40-60

UK, France: 5 Hospitals

IFG

11%

FPG, OGTT, HbA1c, lipids, measured weight, max O2 uptake, self-reported 3-day food record & physical activity log

7

Whittemore, 2009 [78]

CLU

58

21+

USA: Primary care practices

NGT & IGT

12%

Self-reported exercise and nutrition

Measured weight, WC, insulin resistance, lipids

7

McTigue, 2009 [84]

BAC

166

20-79

USA: Primary care practices

Obese, NGT or diabetic

7%

Measured weight

5

Eriksson, 1991 [79]

BAC

181

47-49

Sweden: Borderline diabetes clinic

NGT & IGT

22.8%

Self-reported exercise, max O2 uptake, FPG, OGTT, lipids, measured weight, skinfold, mortality

7

Pagoto, 2008 [14]

B-A

118

Middle age

USA: Academic medical center

Metabolic syndrome, NGT or diabetic

17%

Measured weight, BP,

3

Laatikainen, 2007 [83]

B-A

311

40-75

Australia: General practices

NGT & IGT

23.8%

Self-reported FFQ, SF-36, K10; Measured FPG, 2 hr PG, WC, weight, lipids

7

Absetz, 2005 & 2009 [77, 82]

B-A

352

50-65

Finland: Primary health care centres

NGT & IGT

9.4%

Self-reported 3-day food diary, physical activity,

Measured weight, WC, FPG, lipids

7

  1. BA = before-after; BAC = Before-after with a control group; BP = Blood pressure; CLU = Cluster-randomised trial; FFQ = Food frequency questionnaire; FPG = Fasting plasma glucose; IGT = Impaired glucose tolerance; NGT = Normal glucose tolerance; PA = Physical activity; OGTT = Oral glucose tolerance test; RCT = Randomised controlled trial; WC = Waist circumference.
  2. *Study used for meta-analyses
  3. 1 Higher quality score = higher study quality