Table 1 Detailed description of each component of the transmission function
From: Analysis of the effectiveness of interventions used during the 2009 A/H1N1 influenza pandemic
Component of transmission function | Description |
|---|---|
P trans ( I i , I s ) | Probability of disease transmission from infected to susceptible individual. |
β | Disease transmission coefficient, chosen to achieve baseline epidemics with specific R0 values. |
Susc( I s ) | Age specific susceptibility of infectee or susceptible individual. |
Inf t ( I i ) | Infectiousness of infector as a function of time since infection and symptomatic status. |
AVF( I i , I s ) | Antiviral factor which reduces transmission probability when antiviral based interventions are applied to individuals I i , I s or both. |
The following different situations may arise when we model antiviral effectiveness. | |
AVF( I i , I s ) = 1 - AVE i | if the infected individual is treated with antiviral drugs and no antiviral prophylaxis is applied to the susceptible individual |
AVF( I i , I s ) = 1 - AVE s | if antiviral prophylaxis are applied to the susceptible individual and no antiviral treatment is used with the infected individual |
AVF( I i , I s ) = (1-AVE i )*(1-AVE s ) | if both infected and susceptible individuals are receiving antiviral drugs for treatment and prophylaxis respectively |
AVF( I i , I s ) = 1 | if neither infector nor susceptible individuals are receiving antiviral drugs |