Table 4 Association of Down's syndrome with water fluoride level
From: Association of Down's syndrome and water fluoride level: a systematic review of the evidence
Author (Year) | Crude relative risk | Confounding factors discussed in | Controlled for | Validity score |
|---|---|---|---|---|
| Â | Â | study | Â | Â |
Erickson(1976) | 1.16(p > 0.05) | Maternal age, race | Yes | 3.5 |
| Â | 0.96 (p > 0.05) | Â | Â | Â |
Erickson(1980) | 0.93 (0.7, 1.2) | Maternal age, race | Yes | 3.5 |
Needleman(1974) | 1.14 | Maternal age | No | 2.0 |
Rapaport (1957) | 2.3 (p < 0.01) | Maternal age | No | 2.0 |
| Â | 2.9 (p < 0.01) | Â | Â | Â |
| Â | 2.4 (p < 0.05) | Â | Â | Â |
Rapaport (1963) | 3.0(p < 0.001) | Maternal age, minerals in water | No | 2.0 |
Berry (1958) | 0.84–1.48 | None | No | 1.8 |