From: Association of Down's syndrome and water fluoride level: a systematic review of the evidence
Prospective | Was the study prospective? Was it planned and started prior to the outcome of interest |
 | occurring? Score = 1 or 0 |
Study Design | The study design hierarchy for this review = cohort > before-after > ecological > cross- |
 | sectional. Scores ranged from 0.25–1, with cohort = 1, cross-sectional = 0.25 |
Fluoride Measurement | Was the Fluoride level reliably measured? Scores range between 0–1. |
Confounding Factors | Were confounding factors addressed (measured)? Scores range between 0–1, with 3 or more |
 | factors measured = 1. |
Control for Confounding | Was there adjustment for the possible effect of confounding factors in the analysis or study |
 | design? Scores range between 0–1, with stratification by age and sex = 0.5, other types of |
 | analysis (e.g. regression) = 1. |
Blinding | Were those measuring outcomes and exposures blind to the exposure/outcome status of the |
 | person being assessed? Score = 0 or 1 |
Baseline Survey | Was there a baseline survey at the point of initiation or discontinuation of water fluoridation? |
 | Score = 0 or 1 |
Follow-Up | Was the study conducted an adequate time after the initiation or discontinuation of water |
 | fluoridation to assess effects (5 years)? Score = 0 or 1 |